Journal ArticleDOI
Understanding mast cell heterogeneity at single cell resolution
Gökhan Cildir,Kwok Ho Yip,Harshita Pant,Harshita Pant,Vinay Tergaonkar,Vinay Tergaonkar,Vinay Tergaonkar,Angel F. Lopez,Angel F. Lopez,Damon J. Tumes +9 more
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TLDR
A review of the current understanding of MC development and heterogeneity is provided in this article, where the authors discuss new insights gained from single-cell-based studies that may lead to future research directions and therapeutic opportunities.About:
This article is published in Trends in Immunology.The article was published on 2021-06-01. It has received 15 citations till now.read more
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Non-coding RNA-based regulation of inflammation.
Milad Ashrafizadeh,Ali Zarrabi,Ebrahim Mostafavi,Amir Reza Aref,Gautam Sethi,Lingzhi Wang,Vinay Tergaonkar +6 more
TL;DR: In this paper , a review on miRNAs, lncRNAs and circRNAs as ncRNAs is presented and their potential functions in inflammation regulation and resolution.
Journal ArticleDOI
Mast cells: Therapeutic targets for COVID-19 and beyond.
Hiu Yan Lam,Hiu Yan Lam,Vinay Tergaonkar,Vinay Tergaonkar,Alan Prem Kumar,Alan Prem Kumar,Kwang Seok Ahn +6 more
TL;DR: In this paper, the authors highlight the recent findings on the emerging roles of MCs in the pathogenesis of coronavirus disease-2019 (COVID-19) and discuss the potential for MCs as novel therapeutic targets for COVID-2019 and other non-allergic inflammatory diseases.
Journal ArticleDOI
Mast Cells and Dendritic Cells as Cellular Immune Checkpoints in Immunotherapy of Solid Tumors
Katerina Kalkusova,Sindija Šmite,Elea Darras,Pavla Taborska,Dmitry Stakheev,Luca Vannucci,Jirina Bartunkova,Daniel Smrz +7 more
TL;DR: In this paper , the authors discuss how the immune cells can be used in novel immunotherapeutic modalities to weaken the solid tumor resistance to the immune system and also discuss how this modulation could be used to improve the immunotherapy performance.
Journal ArticleDOI
Defining mast cell differentiation and heterogeneity through single-cell transcriptomics analysis.
TL;DR: The authors provided an overview of the current knowledge on MC progenitor differentiation and characteristics, and MC heterogeneity seen in health versus disease, that are drastically advanced through single-cell profiling technologies.
Journal ArticleDOI
Analyzing Modern Biomolecules: The Revolution of Nucleic-Acid Sequencing – Review
TL;DR: In this article, the authors classify the development of biomolecules into three generations: the first generation allows to sequence small DNA fragments, the second generation increases throughput, reducing turnaround and pricing, and the third generation is currently pushing technology to its limits, being able to sequence single molecules, without previous amplification, which was previously impossible.
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Journal ArticleDOI
Single-cell transcriptomics of 20 mouse organs creates a "Tabula Muris"
Overall coordination,Logistical coordination,Library preparation,Cell type annotation,Principal investigators +4 more
TL;DR: A compendium of single-cell transcriptomic data from the model organism Mus musculus that comprises more than 100,000 cells from 20 organs and tissues is presented, representing a new resource for cell biology and enabling the direct and controlled comparison of gene expression in cell types that are shared between tissues.
Journal ArticleDOI
Transcription Factor GATA-2 Is Required for Proliferation/Survival of Early Hematopoietic Cells and Mast Cell Formation, But Not for Erythroid and Myeloid Terminal Differentiation
TL;DR: It is demonstrated that GATA-2 is required for the expansion of multipotential hematopoietic progenitors and the formation of mast cells, but dispensable for the terminal differentiation of erythroid cells and macrophages.
Journal ArticleDOI
The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease.
TL;DR: The role of AHR in autoimmune and neoplastic diseases of the central nervous system, with a special focus on the gut immune system, the gut–brain axis and the therapeutic potential of targeting A HR in neurological disorders are discussed.
Journal ArticleDOI
A cellular census of human lungs identifies novel cell states in health and in asthma.
Felipe A. Vieira Braga,Gozde Kar,Marijn Berg,Orestes A Carpaij,Krzysztof Polanski,Lukas M. Simon,Sharon Brouwer,Tomás Gomes,Laura Hesse,Jian Jiang,Eirini S. Fasouli,Mirjana Efremova,Roser Vento-Tormo,Carlos Talavera-López,Marnix R. Jonker,Karen Affleck,Subarna Palit,Paulina M. Strzelecka,Paulina M. Strzelecka,Helen V. Firth,Krishnaa T. Mahbubani,Ana Cvejic,Ana Cvejic,Kerstin B. Meyer,Kourosh Saeb-Parsy,Marjan Luinge,Corry-Anke Brandsma,Wim Timens,Ilias Angelidis,Maximilian Strunz,Gerard H. Koppelman,Antoon J. M. van Oosterhout,Herbert B. Schiller,Fabian J. Theis,Maarten van den Berge,Martijn C. Nawijn,Sarah A. Teichmann,Sarah A. Teichmann +37 more
TL;DR: Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs.
Journal ArticleDOI
Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B.
TL;DR: These findings identify a previously unrecognized function for mast cells and mast cell–derived interleukin 10 in limiting leukocyte infiltration, inflammation and tissue damage associated with immunological or innate responses that can injure the skin.