Unfolded Protein Response Regulation in Keloid Cells
Paris D. Butler,Zhen Wang,Daphne P. Ly,Michael T. Longaker,Albert C. Koong,George P. Yang,George P. Yang +6 more
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TLDR
It is demonstrated here that there is a specific up-regulation of one facet of the UPR response, which may represent a specific molecular defect in KFs compared with NFs, and also suggests modulation of theUPR can be used in wound healing therapy.About:
This article is published in Journal of Surgical Research.The article was published on 2011-05-01 and is currently open access. It has received 15 citations till now. The article focuses on the topics: Unfolded protein response.read more
Citations
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Journal ArticleDOI
Endoplasmic Reticulum (ER) Stress and Hypoxia Response Pathways Interact to Potentiate Hypoxia-inducible Factor 1 (HIF-1) Transcriptional Activity on Targets Like Vascular Endothelial Growth Factor (VEGF)
Ethel R. Pereira,Ethel R. Pereira,Karen Frudd,Karen Frudd,Walid Awad,Linda M. Hendershot,Linda M. Hendershot +6 more
TL;DR: Surprisingly, it was found that endoplasmic reticulum stress potentiated HIF-1 activity to transactivate VEGF expression as well as another well characterized target, BNIP3.
Journal ArticleDOI
The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability
Diya Wang,Jianbin Zhang,Wenkai Jiang,Zipeng Cao,Fang Zhao,Tongjian Cai,Michael Aschner,Wenjing Luo +7 more
TL;DR: It is demonstrated that Mn activates the NLRP3-CASP1 inflammasome pathway in the hippocampus of mice and BV2 cells by triggering autophagy-lysosomal dysfunction, leading to hippocampal-dependent impairment in learning and memory, which is associated with the pathogenesis of Alzheimer disease.
Journal ArticleDOI
Fibroblasts from the growing margin of keloid scars produce higher levels of collagen I and III compared with intralesional and extralesional sites: clinical implications for lesional site-directed therapy.
Farhatullah Syed,E. Ahmadi,S A Iqbal,Subir Singh,Duncan A. McGrouther,Ardeshir Bayat,Ardeshir Bayat +6 more
TL;DR: Kloid fibroblasts from the growing margin of the keloid express higher levels of collagen type I and III, and that collagen production is altered by extended cell culture passage.
From endoplasmic reticulum stress to the inflammatory response.
TL;DR: Recently, it has been shown that the endoplasmic reticulum mediates a specific set of intracellular signalling pathways in response to the accumulation of unfolded or misfolded proteins, and these pathways are collectively known as the unfolded-protein response as mentioned in this paper.
Journal ArticleDOI
Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer's Disease Brain.
Mohammad Ejaz Ahmed,Shankar S. Iyer,Shankar S. Iyer,Ramasamy Thangavel,Ramasamy Thangavel,Duraisamy Kempuraj,Duraisamy Kempuraj,Govindhasamy Pushpavathi Selvakumar,Govindhasamy Pushpavathi Selvakumar,Sudhanshu P. Raikwar,Sudhanshu P. Raikwar,Smita Zaheer,Asgar Zaheer,Asgar Zaheer +13 more
TL;DR: The results indicate that in AD, the neuroinflammation promoted by the NLRP3 inflammasome may be amplified and regulated by GMF, which further impairs clearance of protein aggregates mediated by the auto-phagosomal pathway.
References
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Journal ArticleDOI
Signal integration in the endoplasmic reticulum unfolded protein response
David Ron,Peter Walter +1 more
TL;DR: Together, at least three mechanistically distinct arms of the UPR regulate the expression of numerous genes that function within the secretory pathway but also affect broad aspects of cell fate and the metabolism of proteins, amino acids and lipids.
Journal ArticleDOI
Protein folding in the cell.
TL;DR: Folding and assembly of polypeptides in vivo involves other proteins, many of which belong to families that have been highly conserved during evolution.
Journal ArticleDOI
XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
TL;DR: The transcription factor XBP1, a target of ATF6, is identified as a mammalian substrate of such an unconventional mRNA splicing system and it is shown that only the spliced form of X BP1 can activate the UPR efficiently.
Journal ArticleDOI
The mammalian unfolded protein response
TL;DR: In the endoplasmic reticulum (ER), secretory and transmembrane proteins fold into their native conformation and undergo posttranslational modifications important for their activity and structure as mentioned in this paper.
Journal ArticleDOI
From endoplasmic-reticulum stress to the inflammatory response
Kezhong Zhang,Randal J. Kaufman +1 more
TL;DR: New observations suggest that the unfolded-protein response can initiate inflammation, and the coupling of these responses in specialized cells and tissues is now thought to be fundamental in the pathogenesis of inflammatory diseases.
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