Book ChapterDOI
Unraveling the Chemical Interactions of Fungal Endophytes for Exploitation as Microbial Factories
Wen-Xuan Wang,Souvik Kusari,Michael Spiteller +2 more
- pp 353-370
TLDR
The importance of endophytes (particularly endophytic fungi) in plant-microbe associations is highlighted and future strategies that might be employed to investigate the chemical communication within endophytics microbial communities are discussed, which can lead the way toward sustainable industrial production of important compounds using endophyty fungi.Abstract:
Endophytic fungi are a group of mutualistic fungi harbored in plant tissues that are known to provide a plethora of fitness benefits to host plants. It is now firmly established that fungal endophytes have a remarkable capability to produce bioactive secondary metabolites including valuable pharmaceutically relevant agents. Unfortunately, efforts to utilize endophytic fungi as sustainable microbial resources for industrial production of compounds have not yet been successful. Recent studies have revealed that endophytic fungi not only interact with their host plant but also engage in complex communication strategies with associated macro- and microorganisms in order to survive and function in their natural habitat. These multifaceted interactions are difficult to introduce and maintain in vitro under artificial fermentation conditions in the laboratory. Our emerging knowledge on the complex interaction between endophytic fungi and associated organisms as well as the host plants provides a silver lining toward industrial exploitation of endophytes. Herein, we highlight the importance of endophytes (particularly endophytic fungi) in plant-microbe associations and discuss future strategies that might be employed to investigate the chemical communication within endophytic microbial communities, which can lead the way toward sustainable industrial production of important compounds using endophytic fungi.read more
Citations
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Journal ArticleDOI
Production of paclitaxel with anticancer activity by two local fungal endophytes, Aspergillus fumigatus and Alternaria tenuissima
Ahmed A. Ismaiel,Ashraf S. Ahmed,Ismail A. Hassan,El-Sayed R. El-Sayed,Al-Zahraa A. Karam El-Din +4 more
TL;DR: Among 60 fungal endophytes isolated from twigs, bark, and mature leaves of different plant species, two fungal isolates named TXD105 and TER995 were capable of producing paclitaxel in amounts of up to 84.41 and 37.92 μg L−1, respectively and offer new and alternate sources with excellent biotechnological potential for pac litaxel production by fungal fermentation.
Journal ArticleDOI
A novel source of the cardiac glycoside digoxin from the endophytic fungus Epicoccum nigrum: isolation, characterization, production enhancement by gamma irradiation mutagenesis and anticancer activity evaluation
TL;DR: Different endophytic fungi were isolated and screened for their digoxin‐producing ability and strain improvement and different culture conditions were studied for more effective production of digoxin.
Journal ArticleDOI
Discovery of the Anticancer Drug Vinblastine from the Endophytic Alternaria alternata and Yield Improvement by Gamma Irradiation Mutagenesis.
TL;DR: In this article, an isolate of Alternaria alternata was found to produce vinblastine (205·38 μg l-1 ), and the identity of the fungal endophytes was confirmed by UV spectroscopic, high-performance liquid chromatography and electrospray ionization mass spectrometry analyses.
Journal ArticleDOI
Artificial intelligence-guided discovery of anticancer lead compounds from plants and associated microorganisms
TL;DR: An overview of current AI-guided solutions to discover anticancer lead compounds, focusing on natural products from plants and associated microorganisms, can be found in this paper, where the authors present an overview of the current state-of-the-art.
Applications of Probiotic Bacteria and Dairy Foods in Health
Fillipe Luiz Rosa do Carmo,Houem Rabah,Bárbara Fernandes Cordeiro,Sara Heloisa da Silva,Gwénaël Jan,Vasco Azevedo,Rodrigo Dias de Oliveira Carvalho +6 more
TL;DR: This chapter presents the molecular mechanisms triggered by probiotic bacteria to modulate the gut physiology during gastrointestinal disorder and the importance of the gastrointestinal stresses tolerance as a limiting factors for probiotic application.
References
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Journal ArticleDOI
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Journal ArticleDOI
Taxol and Taxane Production by Taxomyces andreanae, an Endophytic Fungus of Pacific Yew
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Journal ArticleDOI
Endophytes: a rich source of functional metabolites.
Ren-Xiang Tan,W. X. Zou +1 more