Journal ArticleDOI
Update 1 of: macrolactonizations in the total synthesis of natural products.
TLDR
Products A. Parenty,† X. Moreau,†,§ Gilles Niel,‡ and J.-M.Abstract:
Products A. Parenty,† X. Moreau,†,§ Gilles Niel,‡ and J.-M. Campagne*,†,‡ †Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, F-91198 Gif sur Yvette, France Institut Lavoisier de Versailles, UMR CNRS 8180, Universite ́ de Versailles-Saint-Quentin-en-Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France ‡Institut Charles Gerhardt, UMR5253, Ecole Nationale Supeŕieure de Chimie, 8 rue de l’Ecole Normale, F-34296 Montpellier, Franceread more
Citations
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Macrocyclization Reactions: The Importance of Conformational, Configurational, and Template-Induced Preorganization
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about concrete mechanical properties such as E-modulus and compressive strength.
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Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles
Xufen Yu,Dianqing Sun +1 more
TL;DR: The primary goal of this review is to summarize currently used macrocyclic drugs, highlight the therapeutic potential of this underexplored drug class and outline the general synthetic methodologies for the synthesis of macrocycles.
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Radical aryl migration enables diversity-oriented synthesis of structurally diverse medium/macro- or bridged-rings
Lei Li,Zhong-Liang Li,Fu-Li Wang,Zhen Guo,Yong-Feng Cheng,Na Wang,Xiaowu Dong,Chao Fang,Jingjiang Liu,Chunhui Hou,Bin Tan,Xin-Yuan Liu +11 more
TL;DR: A radical-based approach for diversity-oriented synthesis of various benzannulated carbon- and heteroatom-containing 8–11(14)-membered ketone libraries is disclosed, which showed potent inhibitory activity against the cancer cell or derivative of human embryonic kidney line in preliminary biological studies.
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Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products
TL;DR: This review investigates the use of complex ester fragment couplings within natural product total synthesis campaigns and presents and discusses a collection of successful examples from the literature.
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Importance and synthesis of benzannulated medium-sized and macrocyclic rings (BMRs)
TL;DR: In this article, the authors highlight the importance of benzannulated medium-sized and macrocyclic rings (BMRs) and the strategies developed over the years for their synthesis.
References
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The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
TL;DR: In this article, a reagent formed by combining diethyl azodicarboxylate (DEAD) and triphenylphosphine (TPP) could be utilized in the intermolecular dehydration between an alcohol and various acidic components such as carboxylic acids, phosphoric diesters, imides, and active methylene compounds.
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A rapid esterification by means of mixed anhydride and its application to large-ring lactonization.
TL;DR: In this paper, a rapid and mild esterification method using carboxylic 2,4,6-trichlorobenzoic anhydrides in the presence of 4-dimethylaminopyridine was developed.
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Polyketide biosynthesis: a millennium review.
James Staunton,Kira J. Weissman +1 more
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Mitsunobu and Related Reactions: Advances and Applications
TL;DR: This review concludes that Etherification without Cyclization and N-Alkylation should be considered as separate science, and the proposed treatment of Etherification with Cyclization as a separate science should be reconsidered.