Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance
Norah A. Terrault,Anna S. Lok,Brian J. McMahon,Kyong-Mi Chang,Jessica P. Hwang,Maureen M. Jonas,Robert S. Brown,Natalie Bzowej,John B. Wong +8 more
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TLDR
This AASLD 2018 Hepatitis B Guidance provides a data-supported approach to screening, prevention, diagnosis, and clinical management of patients with hepatitis B.About:
This article is published in Hepatology.The article was published on 2018-04-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: Hepatitis B & Mass screening.read more
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Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation
Keigo Kawashima,Masanori Isogawa,Masaya Onishi,Ian Baudi,Satoru Saito,Atsushi Nakajima,Takashi Fujita,Yasuhito Tanaka +7 more
TL;DR: In this paper, the expression profile of intrahepatically primed, dysfunctional HBV-specific CD8+ T cells with that of systemically primed, functional effector counterparts was compared.
Journal ArticleDOI
Hepatocellular carcinoma risk in patients with chronic hepatitis B receiving tenofovir-vs. entecavir-based regimens: individual patient data meta-analysis.
Won Choi,Terry Cheuk-Fung Yip,Grace Lai-Hung Wong,W. Ray Kim,Leland J. Yee,Craig Brooks-Rooney,T. Curteis,Harriet E O Cant,Chung-Hwan Chen,Chi-Yi Chen,Yi‐Hsiang Huang,Young-Joo Jin,Dae Won Jun,Jin Wook Kim,Neung Hwa Park,Cheng Yuan Peng,Hyun Phil Shin,Jung Woo Shin,Yao-Hsu Yang,Young-Suk Lim +19 more
TL;DR: In this article , the comparative risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) receiving tenofovir disoproxil fumarate (TDF) vs. entecavir (ETV) remains controversial.
Journal ArticleDOI
Partial Virological Response after 2 Years of Entecavir Therapy Increases the Risk of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Associated Cirrhosis
Seung Kak Shin,Hyung Joon Yim,Jeong Han Kim,Chan Uk Lee,Jong Eun Yeon,Sang Jun Suh,Young Kul Jung,Yun Soo Kim,Ju Hyun Kim,Oh Sang Kwon +9 more
TL;DR: Older age, PVR, and higher FIB-4 index after 2 years of ETV therapy were independent risk factors for HCC, and efforts to accomplish a complete virological response and reduce the FIB -4 index should be made.
Journal ArticleDOI
Cytokines predict virological response in chronic hepatitis B patients receiving peginterferon alfa-2a therapy.
Wenkang Fu,Jie Cao,Ningning Mi,Chongfei Huang,Long Gao,Jinduo Zhang,Ping Yue,Bing Bai,Yanyan Lin,Wenbo Meng +9 more
TL;DR: It is found that cytokine levels before and during treatment may represent potential biomarkers to select CHB patients who can respond to PEG-IFN, and cytokines can be used as an indicator of antiviral drug selection before CHB treatment.
Journal ArticleDOI
Efficacy of long-term tenofovir disoproxil fumarate therapy in chronic hepatitis B patients with partial virologic response in real practice.
TL;DR: The vast majority of patients achieved virologic response (VR) during continuous TDF therapy, thus TDF treatment can be maintained in nucleos(t)ide-naïve patients with PVR at week 48, especially in those with low viremia.
References
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Management of hepatocellular carcinoma.
Jordi Bruix,Morris Sherman +1 more
TL;DR: The prevention of Cirrhosis can prevent the development of HCC and progression from chronic HCV infection to advanced fibrosis or cirrhosis may be prevented in 40% of patients who are sustained responders to new antiviral strategies, such as pegylated interferon and ribavirin.
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AASLD guidelines for the treatment of hepatocellular carcinoma
Julie K. Heimbach,Laura Kulik,Richard S. Finn,Claude B. Sirlin,Michael Abecassis,Lewis R. Roberts,Andrew X. Zhu,M. Hassan Murad,Jorge A. Marrero +8 more
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about concrete mechanical properties such as E-modulus and compressive strength.
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Chronic hepatitis B: Update 2009
Anna S.F. Lok,Brian J. McMahon +1 more
TL;DR: The 2009 update of the American Association for the Study of Liver Diseases (AASLD) Practice Guidelines for Management of Chronic Hepatitis B is now posted online at www.aasld.org, and the recommendation for first-line oral antiviral medications has been changed to tenofovir or entecavir, and adefovir has been moved to second-line Oral antiviral medication.
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Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures
TL;DR: More efficacious treatments, mass immunization programs, and safe injection techniques are essential for eliminating HBV infection and reducing global HBV‐related morbidity and mortality.
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