Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance
Norah A. Terrault,Anna S. Lok,Brian J. McMahon,Kyong-Mi Chang,Jessica P. Hwang,Maureen M. Jonas,Robert S. Brown,Natalie Bzowej,John B. Wong +8 more
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TLDR
This AASLD 2018 Hepatitis B Guidance provides a data-supported approach to screening, prevention, diagnosis, and clinical management of patients with hepatitis B.About:
This article is published in Hepatology.The article was published on 2018-04-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: Hepatitis B & Mass screening.read more
Citations
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Substantial gaps in evaluation and treatment of patients with hepatitis B in the US
TL;DR: In this paper , the proportion of patients with chronic HBV infection who received adequate evaluation, were treatment eligible, and received antiviral treatment using a large, nationwide cohort was determined.
Journal ArticleDOI
Lower level of complement component C3 and C3a in the plasma means poor outcome in the patients with hepatitis B virus related acute-on-chronic liver failure.
Qian Li,Qing Lu,Mengqi Zhu,Chong Huang,Kangkang Yu,Yuxian Huang,Xu Zhao,Xu Zhao,Xing-Guang Luo,Jianming Zheng +9 more
TL;DR: It is demonstrated that the activation of the classical pathway mediated by C1q may play an important role in the pathogenesis of HBV-ACLF and the plasma levels of C3 and C3a may be potential novel biomarkers in predicting the outcome ofHBV- ACLF.
Journal ArticleDOI
Phase Transition Is Infrequent Among North American Adults With e-Antigen-Negative Chronic Hepatitis B and Low-Level Viremia.
Kali Zhou,Abdus S. Wahed,Stewart Cooper,Adrian M. Di Bisceglie,Robert J. Fontana,Marc G. Ghany,Mandana Khalili,Anna S. Lok,Robert P. Perrillo,William M. Lee,Daryl T.-Y. Lau,Richard K. Sterling,Harry L.A. Janssen,Norah A. Terrault +13 more
TL;DR: Most adults in this North American cohort with HBeAg-negative CHB and low-level viremia remained inactive and off treatment over 4 years, and Transition from inactive to active CHB is infrequent and predominantly associated with viral rather than host factors.
Journal ArticleDOI
Review article: current and emerging therapies for the management of cirrhosis and its complications
TL;DR: Cirrhosis is increasingly common and morbid and optimal utilisation of therapeutic strategies to prevent and control the complications of cirrhosis are central to improving clinical and patient‐reported outcomes.
Journal ArticleDOI
Viral hepatitis: Milestones, unresolved issues, and future goals
TL;DR: A review of the current overall knowledge on hepatitis A, B, C, D, and E can be found in this paper, where the authors describe the goals achieved, unresolved issues, and the latest research on this topic may make it possible to speculate on future scenarios.
References
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Management of hepatocellular carcinoma.
Jordi Bruix,Morris Sherman +1 more
TL;DR: The prevention of Cirrhosis can prevent the development of HCC and progression from chronic HCV infection to advanced fibrosis or cirrhosis may be prevented in 40% of patients who are sustained responders to new antiviral strategies, such as pegylated interferon and ribavirin.
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AASLD guidelines for the treatment of hepatocellular carcinoma
Julie K. Heimbach,Laura Kulik,Richard S. Finn,Claude B. Sirlin,Michael Abecassis,Lewis R. Roberts,Andrew X. Zhu,M. Hassan Murad,Jorge A. Marrero +8 more
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about concrete mechanical properties such as E-modulus and compressive strength.
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Chronic hepatitis B: Update 2009
Anna S.F. Lok,Brian J. McMahon +1 more
TL;DR: The 2009 update of the American Association for the Study of Liver Diseases (AASLD) Practice Guidelines for Management of Chronic Hepatitis B is now posted online at www.aasld.org, and the recommendation for first-line oral antiviral medications has been changed to tenofovir or entecavir, and adefovir has been moved to second-line Oral antiviral medication.
Journal ArticleDOI
Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures
TL;DR: More efficacious treatments, mass immunization programs, and safe injection techniques are essential for eliminating HBV infection and reducing global HBV‐related morbidity and mortality.
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