Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance
Norah A. Terrault,Anna S. Lok,Brian J. McMahon,Kyong-Mi Chang,Jessica P. Hwang,Maureen M. Jonas,Robert S. Brown,Natalie Bzowej,John B. Wong +8 more
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TLDR
This AASLD 2018 Hepatitis B Guidance provides a data-supported approach to screening, prevention, diagnosis, and clinical management of patients with hepatitis B.About:
This article is published in Hepatology.The article was published on 2018-04-01 and is currently open access. It has received 2399 citations till now. The article focuses on the topics: Hepatitis B & Mass screening.read more
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Rapidly decreased HBV RNA predicts responses of pegylated interferons in HBeAg-positive patients: a longitudinal cohort study.
Min Zhang,Guangdi Li,Jia Shang,Chen Pan,Minxiang Zhang,Zhibiao Yin,Qing Xie,Yanzhong Peng,Qing Mao,Xinqiang Xiao,Yongfang Jiang,Kaizhong Luo,Yun Xu,Hai Ding,Wenzhou Fan,Vidaurre Diego,Mahmoud Reza Pourkarim,Mahmoud Reza Pourkarim,Erik De Clercq,Guiqiang Wang,Guozhong Gong +20 more
TL;DR: HBV RNA at week 12 is an effective monitor of H beAg seroconversion in HBeAg-positive patients treated with pegylated interferons.
Journal ArticleDOI
Toward a complete cure for chronic hepatitis B: Novel therapeutic targets for hepatitis B virus
TL;DR: In this article , the authors summarized the current knowledge about novel treatments and combination treatments for a complete hepatitis B virus cure, defined by either the loss of hepatitis B surface antigen, undetectable serum HBV DNA levels, and/or seroconversion to hepatitis b surface antibody.
Journal ArticleDOI
Generic sofosbuvir-based interferon-free direct acting antiviral agents for patients with chronic hepatitis C virus infection: a real-world multicenter observational study.
Chen-Hua Liu,Yi-Jie Huang,Sien-Sing Yang,Chung-Hsin Chang,Sheng-Shun Yang,Sheng-Shun Yang,Hsin-Yun Sun,Chun-Jen Liu,Wen-Chun Liu,Tung-Hung Su,Hung-Chih Yang,Chun-Ming Hong,Tai-Chung Tseng,Pei-Jer Chen,Ding-Shinn Chen,Ding-Shinn Chen,Chien-Ching Hung,Chien-Ching Hung,Jia-Horng Kao +18 more
TL;DR: Generic SOF-based regimens are well tolerated and provide high SVR12 rates in patients with chronic HCV infection, and the rates were comparable in terms of baseline patient characteristics and viral decline at week 4 of treatment.
Journal ArticleDOI
Monotherapy with tenofovir disoproxil fumarate for adefovir-resistant vs. entecavir-resistant chronic hepatitis B: A 5-year clinical trial.
Young-Suk Lim,Geum-Youn Gwak,Jonggi Choi,Yung Sang Lee,Kwan Soo Byun,Yoon Jun Kim,Byung Chul Yoo,So Young Kwon,Han Chu Lee +8 more
TL;DR: Up to 240 weeks of TDF monotherapy provided an increasing virologic response rate in heavily pretreated patients with HBV resistant to ETV and/or ADV, however, it was associated with poor serological responses and decreasing renal function and bone mineral density.
Journal ArticleDOI
Cost-effectiveness of antiviral treatment in adult patients with immune-tolerant phase chronic hepatitis B.
TL;DR: Starting antiviral therapy in IT phase is cost-effective compared with delaying the treatment until the active hepatitis phase in CHB patients, especially with increasing HCC risk, decreasing drug costs and consideration of productivity loss.
References
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Management of hepatocellular carcinoma.
Jordi Bruix,Morris Sherman +1 more
TL;DR: The prevention of Cirrhosis can prevent the development of HCC and progression from chronic HCV infection to advanced fibrosis or cirrhosis may be prevented in 40% of patients who are sustained responders to new antiviral strategies, such as pegylated interferon and ribavirin.
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AASLD guidelines for the treatment of hepatocellular carcinoma
Julie K. Heimbach,Laura Kulik,Richard S. Finn,Claude B. Sirlin,Michael Abecassis,Lewis R. Roberts,Andrew X. Zhu,M. Hassan Murad,Jorge A. Marrero +8 more
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about concrete mechanical properties such as E-modulus and compressive strength.
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Chronic hepatitis B: Update 2009
Anna S.F. Lok,Brian J. McMahon +1 more
TL;DR: The 2009 update of the American Association for the Study of Liver Diseases (AASLD) Practice Guidelines for Management of Chronic Hepatitis B is now posted online at www.aasld.org, and the recommendation for first-line oral antiviral medications has been changed to tenofovir or entecavir, and adefovir has been moved to second-line Oral antiviral medication.
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Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures
TL;DR: More efficacious treatments, mass immunization programs, and safe injection techniques are essential for eliminating HBV infection and reducing global HBV‐related morbidity and mortality.
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