Journal ArticleDOI
Use of Azithromycin and Death from Cardiovascular Causes
TLDR
Azithromycin use was not associated with an increased risk of death from cardiovascular causes in a general population of young and middle-aged adults.Abstract:
Background Azithromycin use is associated with an increased risk of death from cardiovascular causes among patients at high baseline risk. Whether azithromycin confers a similar risk in the unselected general population is unknown. Methods We conducted a nationwide historical cohort study involving Danish adults (18 to 64 years of age), linking registry data on filled prescriptions, causes of death, and patient characteristics for the period from 1997 through 2010. We estimated rate ratios for death from cardiovascular causes, comparing 1,102,050 episodes of azithromycin use with no use of antibiotic agents (matched in a 1:1 ratio according to propensity score, for a total of 2,204,100 episodes) and comparing 1,102,419 episodes of azithromycin use with 7,364,292 episodes of penicillin V use (an antibiotic with similar indications; analysis was conducted with adjustment for propensity score). Results The risk of death from cardiovascular causes was significantly increased with current use of azithromycin (...read more
Citations
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Journal ArticleDOI
Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics
TL;DR: This review presents the current understanding of the molecular mechanisms of biofilm recalcitrance toward antibiotics and describes how recent progress has improved the capacity to design original and efficient strategies to prevent or eradicate biofilm-related infections.
Journal ArticleDOI
Azithromycin: mechanisms of action and their relevance for clinical applications.
Michael J. Parnham,Michael J. Parnham,Vesna Eraković Haber,Evangelos J. Giamarellos-Bourboulis,Gianpaolo Perletti,Gianpaolo Perletti,Geert Verleden,Robin Vos +7 more
TL;DR: A sub-group of post-transplant bronchiolitis patients appears to be sensitive to azithromycin, as may be patients with severe sepsis, and other promising indications include chronic prostatitis and periodontitis, but weak activity in malaria is unlikely to prove crucial.
Journal ArticleDOI
An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome
Keith C. Meyer,Ganesh Raghu,Geert Verleden,Paul A. Corris,Paul Aurora,Kevin C. Wilson,Jan Brozek,Allan R. Glanville +7 more
TL;DR: The expert committee discussed the available research evidence and formulated specific recommendations about the use of systemic corticosteroids, cyclosporine, tacrolimus, azithromycin and about re-transplantation in patients with suspected and confirmed BOS.
Journal ArticleDOI
Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: A population-based study
TL;DR: Long-term use of PPIs was still associated with an increased GC risk in subjects even after HP eradication therapy, and the adjusted absolute risk difference for PPIs versus non-PPIs use was 4.29 excess GC per 10 000 person-years.
Journal ArticleDOI
Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa
Jeremy D. Keenan,Robin L. Bailey,Sheila K. West,Ahmed M. Arzika,John Hart,Jerusha Weaver,Khumbo Kalua,Zakayo Mrango,Kathryn J. Ray,Catherine Cook,Elodie Lebas,Kieran S O'Brien,Paul M. Emerson,Travis C. Porco,Thomas M. Lietman +14 more
TL;DR: Among postneonatal, preschool children in sub‐Saharan Africa, childhood mortality was lower in communities randomly assigned to mass distribution of azithromycin than in those assigned to placebo, with the largest effect seen in Niger.
References
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Journal ArticleDOI
The Danish civil registration system
TL;DR: The Danish Civil Registration System (CRS) in connection with other registers and biobanks will continue to provide the basis for significant knowledge relevant to the aetiological understanding and possible prevention of human diseases.
Journal ArticleDOI
The Danish National Patient Register
TL;DR: Although the NPR is overall a sound data source, both the content and the definitions of single variables have changed over time and researchers using the data should carefully consider potential fallacies in the data before drawing conclusions.
Journal ArticleDOI
The Danish National Prescription Registry
TL;DR: The possibility of linkage with many other nationwide individual-level data sources renders the DNPR a very powerful pharmacoepidemiological tool.
Journal ArticleDOI
The Danish Register of Causes of Death
TL;DR: Cause-specific mortality statistics is a valuable source for the identification of risk factors for poor public health and the quality of the register on causes of death relies mainly upon the correctness of the physicians’ notification and the coding in the National Board of Health.
Journal ArticleDOI
Azithromycin and the risk of cardiovascular death.
TL;DR: There was a small absolute increase in cardiovascular deaths, which was most pronounced among patients with a high baseline risk of cardiovascular disease and patients in the highest decile of risk for cardiovascular disease.
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