Vaccinia Virus B18R Gene Encodes a Type I Interferon-binding Protein That Blocks Interferon α Transmembrane Signaling
Reads0
Chats0
TLDR
Among viral host response modifiers, the B18R protein is unique inasmuch as it exists as a soluble extracellular as well as a cell surface protein and thus should effectively block both autocrine and paracrine functions of IFN.About:
This article is published in Journal of Biological Chemistry.The article was published on 1995-07-07 and is currently open access. It has received 389 citations till now. The article focuses on the topics: Interferon binding & Interferon.read more
Citations
More filters
Journal ArticleDOI
Antiviral Actions of Interferons
TL;DR: Tremendous progress has been made in understanding the molecular basis of the antiviral actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the actions of IFNs.
Journal ArticleDOI
Interferons, interferon‐like cytokines, and their receptors
TL;DR: This review summarizes the history of the purification of human IFNs and the key aspects of the current state of knowledge of humanIFN genes, proteins, and receptors and provides some new insights into the development of these proteins as major elements of innate immunity.
Journal ArticleDOI
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures.
TL;DR: Applied aspects that arise from an increase in knowledge in this area are described, including vaccine design and manufacture, the development of novel antiviral drugs and the use of IFN-sensitive oncolytic viruses in the treatment of cancer.
Journal ArticleDOI
Viruses and interferon: a fight for supremacy
TL;DR: The interplay between the IFN system and four medically important and challenging viruses — influenza, hepatitis C, herpes simplex and vaccinia — is discussed to highlight the diversity of viral strategies.
Journal ArticleDOI
Interleukin-10 and Related Cytokines and Receptors
Sidney Pestka,Christopher D. Krause,Devanand Sarkar,Mark R. Walter,Yufang Shi,Paul B. Fisher +5 more
TL;DR: These cytokines have significant roles in a variety of pathophysiological processes as well as in regulation of the immune system and further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for a range of diseases.
References
More filters
Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
TL;DR: A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).
Journal ArticleDOI
Structural design and molecular evolution of a cytokine receptor superfamily.
TL;DR: This work proposes that the approximately 200-residue binding segment of the canonical cytokine receptor is composed of two discrete folding domains that share a significant sequence and structural resemblance with a likely binding site for cytokine ligands.
Journal ArticleDOI
Interferons and their actions.
TL;DR: One that the authors will refer to break the boredom in reading is choosing interferons and their actions as the reading material.
Journal ArticleDOI
A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins
Craig A. Smith,T Davis,Dirk M. Anderson,L Solam,MP Beckmann,Rita Jerzy,Steven K. Dower,David Cosman,Raymond G. Goodwin +8 more
TL;DR: The predicted cysteine-rich extracellular domain has extensive sequence similarity with five proteins, including nerve growth factor receptor and a transcriptionally active open reading frame from Shope fibroma virus, and thus defines a family of receptors.
Journal ArticleDOI
A workbench for multiple alignment construction and analysis.
TL;DR: An interactive program, MACAW (Multiple Alignment Construction and Analysis Workbench), that allows the user to construct multiple alignments by locating, analyzing, editing, and combining “blocks” of aligned sequence segments.
Related Papers (5)
Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species soecificity
A soluble receptor for interleukin-1β encoded by vaccinia virus: A novel mechanism of virus modulation of the host response to infection
Antonio Alcami,Geoffrey L. Smith +1 more