Vagal Nerve Stimulation for Treatment-Resistant Depression.
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TLDR
VNS affects many of the same brain areas, neurotransmitters and signal transduction mechanisms as those found with traditional antidepressants, Nevertheless, the mechanisms by which VNS benefits patients nonresponsive to conventional antidepressants is unclear, with further research needed to clarify this.About:
This article is published in Neurotherapeutics.The article was published on 2017-07-01 and is currently open access. It has received 128 citations till now. The article focuses on the topics: Vagus nerve stimulation & Treatment-resistant depression.read more
Citations
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Journal ArticleDOI
Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders.
TL;DR: Various functions of the vagus nerve are discussed, which make it an attractive target in treating psychiatric and gastrointestinal disorders and preliminary evidence for gut bacteria to have beneficial effect on mood and anxiety, partly by affecting the activity of thevagus nerve.
Journal ArticleDOI
A Neural Circuit for Gut-Induced Reward.
Wenfei Han,Wenfei Han,Luis A. Tellez,Matthew H. Perkins,Isaac O. Perez,Taoran Qu,Jozélia G. Ferreira,Jozélia G. Ferreira,Tatiana L. Ferreira,Tatiana L. Ferreira,Daniele Quinn,Zhong-Wu Liu,Xiao-Bing Gao,Melanie Maya Kaelberer,Diego V. Bohórquez,Sara J. Shammah-Lagnado,Guillaume de Lartigue,Ivan E. de Araujo +17 more
TL;DR: The findings establish the vagal gut-to-brain axis as an integral component of the neuronal reward pathway and suggest novel vagal stimulation approaches to affective disorders.
Journal ArticleDOI
Bipolar Disorder and Suicide: a Review.
Jake N. Miller,Donald W. Black +1 more
TL;DR: Understanding clinical and demographic risk factors for suicide in bipolar disorder remains the best way to prevent suicidal behavior.
Journal ArticleDOI
Management of Treatment-Resistant Depression: Challenges and Strategies.
Daphne Voineskos,Zafiris J. Daskalakis,Zafiris J. Daskalakis,Daniel M. Blumberger,Daniel M. Blumberger +4 more
TL;DR: The review of the evidence suggests that further large-scale work is necessary to understand the appropriate treatment pathways for TRD and to prescribe effective therapeutic options for patients suffering from TRD.
Journal ArticleDOI
Heart Rate Variability as Indicator of Clinical State in Depression.
TL;DR: Change in HRV parameter values correlated with changes in symptom severity of depression, which may help to underpin utilization of HRV parameters are bio-maker for disease state in depression.
References
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Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
Luca Santarelli,Michael Saxe,Cornelius Gross,Alexandre Surget,Fortunato Battaglia,Stephanie C. Dulawa,Noelia V. Weisstaub,James T. Lee,Ronald S. Duman,Ottavio Arancio,Catherine Belzung,René Hen +11 more
TL;DR: It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
Journal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
Journal ArticleDOI
The catecholamine hypothesis of affective disorders: a review of supporting evidence
TL;DR: The "catecholamine hypothesis of affective disorders" as discussed by the authors suggests that depression is associated with an absolute or relative decrease in catecholamines, particularly norepinephrine, available at central adrenergic receptor sites.
Journal ArticleDOI
A neurotrophic model for stress-related mood disorders.
TL;DR: Analysis of preclinical cellular and behavioral models of depression and antidepressant actions, as well as clinical neuroimaging and postmortem studies, are consistent with the hypothesis that decreased expression of BDNF and possibly other growth factors contributes to depression and that upregulation ofBDNF plays a role in the actions of antidepressant treatment.
Journal ArticleDOI
Regulation of BDNF and trkB mRNA in Rat Brain by Chronic Electroconvulsive Seizure and Antidepressant Drug Treatments
TL;DR: The enhanced induction and prolonged expression of BDNF in response to chronic ECS and antidepressant drug treatments could promote neuronal survival, and protect neurons from the damaging effects of stress.
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