Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho
TLDR
Mounting evidence supports a well-supported protective role for α-Klotho on VC and a thorough systemic evaluation of the biomedical interplay of phosphate, FGF23, and α-Lotho may potentially lead to new therapeutic options for patients with CKD-MBD.About:
This article is published in Bone.The article was published on 2017-07-01 and is currently open access. It has received 195 citations till now. The article focuses on the topics: Fibroblast growth factor 23 & Population.read more
Citations
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Journal ArticleDOI
Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness.
TL;DR: Comparison and contrast the role of VSMCs in driving calcification in both atherosclerosis and in the vessel media focusing on the major drivers of calcification, including aging, uraemia, mechanical stress, oxidative stress, and inflammation are compared.
Journal ArticleDOI
Vascular Calcification-New Insights Into Its Mechanism.
TL;DR: To facilitate the understanding of vascular calcification, across any number of bioscientific disciplines, this review of a detailed updated molecular mechanism of VC encompasses a vascular smooth muscle phenotypic of osteogenic differentiation, and multiple signaling pathways of VC induction, including the roles of inflammation and cellular microorganelle genesis.
Journal ArticleDOI
The role of klotho in chronic kidney disease.
TL;DR: The role and pathophysiological implications of klotho in ion disorders, the inflammation response, vascular calcification, mineral bone disorders, and renal fibrosis in CKD are discussed and its potential applications as a diagnostic and/or prognostic biomarker for CKD and as a novel treatment strategy to improve and decrease the burden of comorbidity are discussed.
Journal ArticleDOI
Potential application of klotho in human chronic kidney disease
Javier A. Neyra,Ming Chang Hu +1 more
TL;DR: Klotho is not only a diagnostic and/or prognostic marker for CKD, but the treatment of Klotho deficiency may be a promising strategy to prevent, retard, and decrease the burden of comorbidity in CKD.
Journal ArticleDOI
X-Linked Hypophosphatemia and FGF23-Related Hypophosphatemic Diseases: Prospect for New Treatment.
Yuka Kinoshita,Seiji Fukumoto +1 more
TL;DR: A humanized monoclonal antibody for FGF23 (burosumab) is a promising treatment in patients with XLH and TIO and will focus on the phosphate metabolism and the pathogenesis and treatment of F GF23-related hypophosphatemic diseases.
References
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Journal ArticleDOI
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,Hiroki Aizawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,Hitoshi Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Ryozo Nagai,Yo-ichi Nabeshima +16 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, and may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Journal ArticleDOI
Coronary-Artery Calcification in Young Adults with End-Stage Renal Disease Who Are Undergoing Dialysis
William G. Goodman,Jonathan G. Goldin,Beatriz D. Kuizon,Chun Yoon,Barbara Gales,Donna Sider,Yan Wang,Joanie Chung,Aletha Emerick,Lloyd E. Greaser,Robert Elashoff,Isidro B. Salusky +11 more
TL;DR: Coronary-artery calcification is common and progressive in young adults with end-stage renal disease who are undergoing dialysis who are undergoing dialysis.
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,H. Arawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,H. Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Yo-ichi Nabeshima,K. Sharma,L. Kelly,T. Dandekar +18 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, including short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema as mentioned in this paper.
Journal ArticleDOI
Mineral Metabolism, Mortality, and Morbidity in Maintenance Hemodialysis
Geoffrey A. Block,Preston S. Klassen,J. Michael Lazarus,Norma J. Ofsthun,Edmund G. Lowrie,Glenn M. Chertow +5 more
TL;DR: Hyperphosphatemia and hyperparathyroidism were significantly associated with all-cause, cardiovascular, and fracture-related hospitalization, and the population attributable risk percentage for disorders of mineral metabolism was 17.5%, owing largely to the high prevalence of hyperph phosphatemia.
Journal ArticleDOI
Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study
TL;DR: This study concludes that a large percentage of hemodialysis patients who have a serum phosphorus level above 6.5 mg/dL and that this places them at increased risk of death, and supports the need for vigorous control of hyperphosphatemia to improve patient survival.
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