Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women.
Miriam A. Bredella,Martin Torriani,Reza Hosseini Ghomi,Bijoy J. Thomas,Danielle J. Brick,Anu V. Gerweck,Clifford J. Rosen,Anne Klibanski,Karen K. Miller +8 more
TLDR
The study showed that vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF‐1 and BMD, which suggests that the detrimental effect of visceral fat on bone health may be mediated in part by IGF-1 as an important regulator of the fat and bone lineage.Abstract:
Recent studies have demonstrated an important physiologic link between bone and fat. Bone and fat cells arise from the same mesenchymal precursor cell within bone marrow, capable of differentiation into adipocytes or osteoblasts. Increased BMI appears to protect against osteoporosis. However, recent studies have suggested detrimental effects of visceral fat on bone health. Increased visceral fat may also be associated with decreased growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels which are important for maintenance of bone homeostasis. The purpose of our study was to assess the relationship between vertebral bone marrow fat and trabecular bone mineral density (BMD), abdominal fat depots, GH and IGF-1 in premenopausal women with obesity. We studied 47 premenopausal women of various BMI (range: 18–41 kg/m2, mean 30 ± 7 kg/m2) who underwent vertebral bone marrow fat measurement with proton magnetic resonance spectroscopy (1H-MRS), body composition, and trabecular BMD measurement with computed tomography (CT), and GH and IGF-1 levels. Women with high visceral fat had higher bone marrow fat than women with low visceral fat. There was a positive correlation between bone marrow fat and visceral fat, independent of BMD. There was an inverse association between vertebral bone marrow fat and trabecular BMD. Vertebral bone marrow fat was also inversely associated with IGF-1, independent of visceral fat. Our study showed that vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 and BMD. This suggests that the detrimental effect of visceral fat on bone health may be mediated in part by IGF-1 as an important regulator of the fat and bone lineage.read more
Citations
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Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?
Qing Chen,Qing Chen,Peishun Shou,C Zheng,M Jiang,G Cao,Q Yang,J Cao,N Xie,Tania Velletri,X Zhang,Chunliang Xu,L Zhang,Huilin Yang,J Hou,Ying Wang,Yufang Shi +16 more
TL;DR: External factors and their signaling processes dictating the reciprocal regulation between adipocytes and osteoblasts during MSC differentiation and the ultimate control of the adipo-osteogenic balance are reviewed.
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Marrow fat and bone--new perspectives.
Pouneh K. Fazeli,Mark C. Horowitz,Ormond A. MacDougald,Erica L. Scheller,Matthew S. Rodeheffer,Clifford J. Rosen,Anne Klibanski +6 more
TL;DR: It is concluded that whereas most animal and human data demonstrate an inverse association between marrow adipose tissue and measures of bone density and strength, understanding the functional significance of marrow adiposes tissue and its hormonal determinants will be critical to better understanding its role in skeletal integrity.
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Dynamic niches in the origination and differentiation of haematopoietic stem cells
TL;DR: New insights are found that significantly improve the understanding of haematopoiesis and raise fundamental questions about what truly constitutes a stem cell niche.
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Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures.
Janina M. Patsch,Xiaojuan Li,Thomas Baum,Samuel P. Yap,Dimitrios C. Karampinos,Ann V. Schwartz,Thomas M. Link +6 more
TL;DR: It is suggested that altered bone marrow fat composition is linked with fragility fractures and diabetes and MRS of spinal bone marrowfat may serve as a novel tool for BMD‐independent fracture risk assessment.
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New Insights into Osteoporosis: The Bone-Fat Connection
TL;DR: New insights into osteoporosis: the bone–fat connection are found in Osaka, Japan and São Paulo, Brazil.
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