Journal ArticleDOI
Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae)
Soon Huat Tiong,Chung Yeng Looi,Aditya Arya,Won Fen Wong,Hazrina Hazni,Mohd Rais Mustafa,Khalijah Awang +6 more
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TLDR
Vindogentianine exhibited potential hypoglycemic activity in β-TC6 and C2C12 cells by inducing higher glucose uptake and significant in vitro PTP-1B inhibition, implying its therapeutic potential against type 2 diabetes.About:
This article is published in Fitoterapia.The article was published on 2015-04-01. It has received 58 citations till now. The article focuses on the topics: Vindoline & Catharanthus.read more
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Stedman's Medical Dictionary
TL;DR: This new edition includes more than 107,000 terms and definitions, including new consultants for the specialties of endocrinology, gastroenterology, geriatrics, and rheumatology.
Journal ArticleDOI
An update on natural compounds in the remedy of diabetes mellitus: A systematic review.
Hira Choudhury,Manisha Pandey,Chua Kui Hua,Cheah Shi Mun,Jessmie Koh Jing,Lillian Kong,Liang Yee Ern,Nik Ahmad Ashraf,Soohg Wai Kit,Tan Sin Yee,Mallikarjuna Rao Pichika,Bapi Gorain,Prashant Kesharwani,Prashant Kesharwani +13 more
TL;DR: This review focuses on the herbal and natural remedies that play the role in the treatment or prevention of this morbid disorder – diabetes, including their underlying mechanisms for the blood glucose-lowering property and the herbal products already been marketed for the remedial action of diabetes.
Journal ArticleDOI
Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review
TL;DR: There is variation in the availability and quality of pharmacological, chemical and clinical studies to explain traditional use of medicinal plants used to manage diabetes in Central America and of the current scientific knowledge that might explain their traditional use.
Journal ArticleDOI
Synthesis of alpha amylase inhibitors based on privileged indole scaffold.
Tayyaba Noreen,Muhammad Taha,Syahrul Imran,Sridevi Chigurupati,Fazal Rahim,Manikandan Selvaraj,Nor Hadiani Ismail,Jahidul Islam Mohammad,Hayat Ullah,Muhammad Javid,Faisal Nawaz,Maryam Irshad,Maryam Irshad,Muhammad Ali +13 more
TL;DR: Structural-activity relationship was established through the interaction of the active compounds with enzyme active site with the help of docking studies, and all other analogs displayed good to moderate inhibitory potential.
Journal ArticleDOI
Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine
P. P. Dhyani,Cristina Quispe,Eshita Sharma,Amit Bahukhandi,Priyanka Sati,Dharam Chand Attri,Agnieszka Szopa,Javad Sharifi-Rad,Anca Oana Docea,Ileana Mardare,Daniela Calina,William C. Cho +11 more
TL;DR: In this article , a spectrum of promising secondary plant metabolites such as colchicine, vinblastine and vincamine have been reviewed in order to develop an effective, affordable, and cost effective cancer management program using these alkaloids.
References
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Journal ArticleDOI
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
Mounib Elchebly,Paul Payette,Eva Michaliszyn,Wanda Cromlish,Susan Collins,Ailsa Lee Loy,Denis Normandin,Alan Cheng,Jean Himms-Hagen,Chi-Chung Chan,Chidambaram Ramachandran,Michael J. Gresser,Michel L. Tremblay,Brian P. Kennedy +13 more
TL;DR: In this article, the mouse homolog of the gene encoding PTP-1B yielded healthy mice that, in the fed state, had blood glucose concentrations that were slightly lower and concentrations of circulating insulin that were one-half those of their PTP−1B+/+ littermates.
Journal ArticleDOI
Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice
Lori D. Klaman,Olivier Boss,Odile D. Peroni,Jason K. Kim,Jennifer L. Martino,Janice M. Zabolotny,Nadeem Moghal,Margaret Lubkin,Young-Bum Kim,Arlene H. Sharpe,Alain Stricker-Krongrad,Gerald I. Shulman,Benjamin G. Neel,Barbara B. Kahn +13 more
TL;DR: PTP-1B is identified as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo and is implicated in the regulation of insulin action and signal transduction pathways.
Journal ArticleDOI
Antidiabetic plants and their active constituents.
TL;DR: This review provides information on more than 1200 species of plants reported to have been used to treat diabetes and/or investigated for antidiabetic activity, with a detailed review of representative plants and some of great diversity of plant constituents with hypoglycemic activity.
Book
Stedman's Medical Dictionary
TL;DR: This special edition of "Stedman's Medical Dictionary, 27th Edition" features a 128-page, four-color veterinary insert, as well as the MediClip Veterinary Anatomy collection on CD-ROM, providing veterinary students and professionals with fast and easy access to pertinent information with a timely and no-nonsense approach.
Journal ArticleDOI
Stedman's Medical Dictionary
TL;DR: This new edition includes more than 107,000 terms and definitions, including new consultants for the specialties of endocrinology, gastroenterology, geriatrics, and rheumatology.