Vitamin D and Bronchial Asthma: An Overview of Data From the Past 5 Years.
TLDR
Despite the conflicting data obtained from clinical trials, vitamin D deficiency may influence the inflammatory response in the airways and further studies are needed to determine the exact mechanisms by which vitamin D supplementation may induce antiinflammatory effects.About:
This article is published in Clinical Therapeutics.The article was published on 2017-05-01 and is currently open access. It has received 78 citations till now. The article focuses on the topics: vitamin D deficiency & Vitamin D and neurology.read more
Citations
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Journal ArticleDOI
Modulation of inflammatory and immune responses by vitamin D
TL;DR: Although knowledge of calcitriol as modulator of immune and inflammatory reactions has dramatically increased in the past decades, further in vivo and clinical studies are needed to confirm the potential benefits of VitD in the control of immune or inflammatory conditions.
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Asthma epidemiology and risk factors
TL;DR: Recent trends in the prevalence of asthma and recent studies that investigate risk factors of asthma are reviewed.
Journal ArticleDOI
Extra-Skeletal Effects of Vitamin D
Rose Marino,Madhusmita Misra +1 more
TL;DR: This review examines available evidence to date for the extra-skeletal effects of vitamin D deficiency, with a focus on randomized controlled trials and meta-analyses.
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Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma.
Eva Morales,David L. Duffy +1 more
TL;DR: Time of asthma onset is considered, since identified gene-environment interactions seldom replicate for childhood and adult asthma, which suggests that asthma susceptibility to environmental exposures may biologically differ from early life to adulthood as a result of different pathways and mechanisms of the disease.
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Association between vitamin D status and asthma control: A meta-analysis of randomized trials
TL;DR: Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency, and had a positive effect on pulmonary function in Patients with air limitation and vitamin D Insufficiency.
References
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Vitamin D insufficiency
Tom D. Thacher,Bart L. Clarke +1 more
TL;DR: This work selected studies with the strongest level of evidence for clinical decision making related to vitamin D and health outcomes from the personal libraries of the vitamin D literature and from a search of the PubMed database using the term vitamin D in combination with the following terms related to the potential nonskeletal benefits of vitamin D: mortality, cardiovascular, diabetes mellitus, cancer, multiple sclerosis, allergy, asthma, infection, depression, psychiatric, and pain.
Journal ArticleDOI
Role of viral respiratory infections in asthma and asthma exacerbations
TL;DR: There is evidence that deficiencies in antiviral activity and the integrity of the airway epithelial barrier could make individuals with asthma more likely to have severe viral respiratory infections of the lower airway, and thus increase the risk of exacerbation.
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World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics
Alessandro Fiocchi,Ruby Pawankar,Carlos A. Cuello-Garcia,Carlos A. Cuello-Garcia,Kangmo Ahn,Suleiman Al-Hammadi,Arnav Agarwal,Arnav Agarwal,Kirsten Beyer,Wesley Burks,Giorgio Walter Canonica,Motohiro Ebisawa,Shreyas Gandhi,Shreyas Gandhi,Rose Kamenwa,Bee Wah Lee,Haiqi Li,Susan L. Prescott,John J. Riva,Lanny J. Rosenwasser,Hugh A. Sampson,Michael Spigler,Luigi Terracciano,Andrea Vereda-Ortiz,Susan Waserman,Juan José Yepes-Nuñez,Jan Brozek,Holger J. Schünemann +27 more
TL;DR: WAO recommendations about probiotic supplementation for prevention of allergy are intended to support parents, clinicians and other health care professionals in their decisions whether to use probiotics in pregnancy and during breastfeeding, and whether to give them to infants.
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Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial.
Augusto A. Litonjua,Augusto A. Litonjua,Vincent J. Carey,Vincent J. Carey,Nancy Laranjo,Benjamin J. Harshfield,Thomas F. McElrath,Thomas F. McElrath,George T. O'Connor,Megan Sandel,Ronald E. Iverson,Aviva Lee-Paritz,Robert C. Strunk,Robert C. Strunk,Leonard B. Bacharier,Leonard B. Bacharier,George A. Macones,Robert S. Zeiger,Michael Schatz,Bruce W. Hollis,Eve Hornsby,Catherine M. Hawrylowicz,Ann Chen Wu,Scott T. Weiss,Scott T. Weiss +24 more
TL;DR: In pregnant women at risk of having a child with asthma, supplementation with 4400 IU/d of vitamin D compared with 400IU/d significantly increased vitamin D levels in the women, but this did not meet statistical significance; however, the study may have been underpowered.
Journal ArticleDOI
Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.
Mario Castro,Tonya S. King,Susan J. Kunselman,Michael D. Cabana,Loren C. Denlinger,Fernando Holguin,Shamsah Kazani,Wendy C. Moore,James N. Moy,Christine A. Sorkness,Pedro C. Avila,Leonard B. Bacharier,Eugene R. Bleecker,Homer A. Boushey,James F. Chmiel,Anne M. Fitzpatrick,Deborah A. Gentile,Mandeep Hundal,Elliot Israel,Monica Kraft,Jerry A. Krishnan,Craig LaForce,Stephen C. Lazarus,Robert F. Lemanske,Njira L Lugogo,Richard J. Martin,David T. Mauger,Edward T. Naureckas,Stephen P. Peters,Wanda Phipatanakul,Loretta G. Que,Ajay Sheshadri,Lewis J. Smith,Julian Solway,Lisa Sullivan-Vedder,Kaharu Sumino,Michael E. Wechsler,Sally E. Wenzel,Steven R. White,E. Rand Sutherland +39 more
TL;DR: Vitamin D3 did not reduce the rate of first treatment failure or exacerbation in adults with persistent asthma and vitamin D insufficiency, and findings do not support a strategy of therapeutic vitamin D3 supplementation in patients with symptomatic asthma.