L
Lewis J. Smith
Researcher at Northwestern University
Publications - 170
Citations - 8927
Lewis J. Smith is an academic researcher from Northwestern University. The author has contributed to research in topics: Asthma & FEV1/FVC ratio. The author has an hindex of 49, co-authored 167 publications receiving 7949 citations. Previous affiliations of Lewis J. Smith include University of California, San Francisco & United States Department of Veterans Affairs.
Papers
More filters
Journal ArticleDOI
Percent emphysema, airflow obstruction, and impaired left ventricular filling.
R. Graham Barr,David A. Bluemke,Firas S. Ahmed,J. Jeffery Carr,Paul L. Enright,Eric A. Hoffman,Rui Jiang,Steven M. Kawut,Richard A. Kronmal,Joao A.C. Lima,Eyal Shahar,Lewis J. Smith,Karol E. Watson +12 more
TL;DR: In a population-based study, a greater extent of emphysema on CT scanning and more severe airflow obstruction were linearly related to impaired left ventricular filling, reduced stroke volume, and lower cardiac output without changes in the ejection fraction.
Journal ArticleDOI
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Florence Demenais,Florence Demenais,Patricia Margaritte-Jeannin,Patricia Margaritte-Jeannin,Kathleen C. Barnes,William O.C.M. Cookson,Janine Altmüller,Wei Ang,R. Graham Barr,Terri H. Beaty,Allan B. Becker,John Beilby,Hans Bisgaard,Unnur S. Bjornsdottir,Eugene R. Bleecker,Klaus Bønnelykke,Dorret I. Boomsma,Emmanuelle Bouzigon,Emmanuelle Bouzigon,Christopher E. Brightling,Myriam Brossard,Myriam Brossard,Guy Brusselle,Guy Brusselle,Esteban G. Burchard,Kristin M. Burkart,Andrew Bush,Andrew Bush,Moira Chan-Yeung,Kian Fan Chung,Kian Fan Chung,Alexessander Couto Alves,John A. Curtin,Adnan Custovic,Denise Daley,Johan C. de Jongste,Blanca E. Del-Rio-Navarro,Kathleen M. Donohue,Liesbeth Duijts,Celeste Eng,Johan G. Eriksson,Martin Farrall,Yuliya Fedorova,Bjarke Feenstra,Manuel A. R. Ferreira,Maxim B. Freidin,Zofia K. Z. Gajdos,Zofia K. Z. Gajdos,Jim Gauderman,Ulrike Gehring,Frank Geller,Jon Genuneit,Sina A. Gharib,Frank D. Gilliland,Raquel Granell,Penelope E. Graves,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Tari Haahtela,Susan R. Heckbert,Dick Heederik,Joachim Heinrich,Markku Heliövaara,John Henderson,Blanca E. Himes,Hiroshi Hirose,Joel N. Hirschhorn,Joel N. Hirschhorn,Albert Hofman,Albert Hofman,Patrick G. Holt,Jouke J. Hottenga,Thomas J. Hudson,Thomas J. Hudson,Jennie Hui,Medea Imboden,Medea Imboden,Vladimir P. Ivanov,Vincent W. V. Jaddoe,Alan James,Alan James,Christer Janson,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Deborah Jarvis,Graham Jones,Ingileif Jonsdottir,Ingileif Jonsdottir,Pekka Jousilahti,Michael Kabesch,Mika Kähönen,David B. Kantor,A. S. Karunas,Elza Khusnutdinova,Gerard H. Koppelman,Anita L. Kozyrskyj,Eskil Kreiner,Michiaki Kubo,Rajesh Kumar,Rajesh Kumar,Ashok Kumar,Ashok Kumar,Ashok Kumar,Mikko Kuokkanen,Mikko Kuokkanen,Lies Lahousse,Lies Lahousse,Tarja Laitinen,Catherine Laprise,Mark Lathrop,Susanne Lau,Young-Ae Lee,Young-Ae Lee,Terho Lehtimäki,Sébastien Letort,Sébastien Letort,Albert M. Levin,Guo Li,Liming Liang,Laura R. Loehr,Stephanie J. London,Daan W. Loth,Ani Manichaikul,Ingo Marenholz,Ingo Marenholz,Fernando J. Martinez,Melanie C. Matheson,Rasika A. Mathias,Kenji Matsumoto,Hamdi Mbarek,Wendy L. McArdle,Mads Melbye,Mads Melbye,Mads Melbye,Erik Melén,Erik Melén,Deborah A. Meyers,Sven Michel,Hamida Mohamdi,Hamida Mohamdi,Arthur W. Musk,Arthur W. Musk,Rachel A. Myers,Maartje A.E. Nieuwenhuis,Emiko Noguchi,George T. O'Connor,George T. O'Connor,Ludmila M. Ogorodova,Cameron D. Palmer,Cameron D. Palmer,Aarno Palotie,Aarno Palotie,Aarno Palotie,Julie E. Park,Craig E. Pennell,Göran Pershagen,Göran Pershagen,Alexey Polonikov,Dirkje S. Postma,Nicole Probst-Hensch,Nicole Probst-Hensch,V. P. Puzyrev,Benjamin A. Raby,Olli T. Raitakari,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Stephen S. Rich,Colin F. Robertson,Isabelle Romieu,Muhammad T. Salam,Veikko Salomaa,Vivi Schlünssen,Robert A. Scott,P. A. Selivanova,Torben Sigsgaard,Angela Simpson,Valérie Siroux,Valérie Siroux,Lewis J. Smith,Maria Solodilova,Marie Standl,Kari Stefansson,Kari Stefansson,David P. Strachan,Bruno H. Stricker,Atsushi Takahashi,Philip J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Carla M. T. Tiesler,Dara G. Torgerson,Tatsuhiko Tsunoda,André G. Uitterlinden,Ralf J. P. van der Valk,Amaury Vaysse,Amaury Vaysse,Sailaja Vedantam,Sailaja Vedantam,Andrea von Berg,Erika von Mutius,Judith M. Vonk,Johannes Waage,Nicholas J. Wareham,Scott T. Weiss,Wendy B. White,Magnus Wickman,Magnus Wickman,Elisabeth Widen,Gonneke Willemsen,L. Keoki Williams,Inge M. Wouters,James J. Yang,Jing Hua Zhao,Miriam F. Moffatt,Carole Ober,Dan L. Nicolae +216 more
TL;DR: A meta-analysis of GWAS studies for asthma from multiancestral cohorts identifies five new loci and finds that the asthma-associated loci are enriched near enhancer marks in immune cells, suggesting a major role of these loci in the regulation of immunologically related mechanisms.
Journal ArticleDOI
Effects of 6 weeks of therapy with oral doses of ICI 204,219, a leukotriene D4 receptor antagonist, in subjects with bronchial asthma
TL;DR: Diary card assessments showed that treatment with increasing doses of ICI 204,219 linearly improved five efficacy criteria without increasing the number or severity of adverse events and may provide a new treatment option for the disease.
Journal ArticleDOI
Tobramycin Solution for Inhalation Reduces Sputum Pseudomonas Aeruginosa Density in Bronchiectasis
Alan F. Barker,Leslie Couch,Stanley B. Fiel,Mark H. Gotfried,Jonathan Ilowite,Keith C. Meyer,Anne O'Donnell,Steven A. Sahn,Lewis J. Smith,Jack O. Stewart,Tammy Abuan,Heather Tully,Jill M. Van Dalfsen,Charles D. Wells,Joanne Quan +14 more
TL;DR: Investigators indicated that 62% of TSI patients showed an improved medical condition compared with 38% of placebo patients, and more TSI-treated patients than placebo patients reported increased cough, dyspnea, wheezing, and noncardiac chest pain, but the symptoms did not limit therapy.
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Florence Demenais,Patricia Margaritte-Jeannin,Kathleen C. Barnes,William O.C.M. Cookson,Janine Altmueller,Wei Ang,R. Graham Barr,Terri H. Beaty,Allan B. Becker,John Beilby,Hans Bisgaard,Unnur S. Bjornsdottir,Eugene R. Bleecker,Klaus Bønnelykke,Dorret I. Boomsma,Emmanuelle Bouzigon,Christopher E. Brightling,Myriam Brossard,Guy Brusselle,Esteban G. Burchard,Kristin M. Burkart,Andrew Bush,Moira Chan-Yeung,Kian Fan Chung,Alexessander Couto Alves,John A. Curtin,Adnan Custovic,Denise Daley,Johan C. de Jongste,Blanca E. Del-Rio-Navarro,Kathleen M. Donohue,Liesbeth Duijts,Celeste Eng,Johan G. Eriksson,Martin Farrall,Yuliya Fedorova,Bjarke Feenstra,Manuel A. R. Ferreira,Maxim B. Freidin,Zofia K. Z. Gajdos,Jim Gauderman,Ulrike Gehring,Frank Geller,Jon Genuneit,Sina A. Gharib,Frank D. Gilliland,Raquel Granell,Penelope E. Graves,Daniel F. Gudbjartsson,Tari Haahtela,Susan R. Heckbert,Dick Heederik,Joachim Heinrich,Markku Heliövaara,John Henderson,Blanca E. Himes,Hiroshi Hirose,Joel N. Hirschhorn,Albert Hofman,Patrick G. Holt,Jouke J. Hottenga,Thomas J. Hudson,Jennie Hui,Medea Imboden,Vladimir P. Ivanov,Vincent W. V. Jaddoe,Alan James,Christer Janson,Marjo-Riitta Järvelin,Deborah Jarvis,Graham Jones,Ingileif Jonsdottir,Pekka Jousilahti,Michael Kabesch,Mika Kähönen,David B. Kantor,A. S. Karunas,Elza Khusnutdinova,Gerard H. Koppelman,Anita L. Kozyrskyj,Eskil Kreiner,Michiaki Kubo,Rajesh Kumar,Ashok Kumar,Mikko Kuokkanen,Lies Lahousse,Tarja Laitinen,Catherine Laprise,Mark Lathrop,Susanne Lau,Young-Ae Lee,Terho Lehtimäki,Sébastien Letort,Albert M. Levin,Guo Li,Liming Liang,Laura R. Loehr,Stephanie J. London,Daan W. Loth,Ani Manichaikul,Ingo Marenholz,Fernando J. Martinez,Melanie C. Matheson,Rasika A. Mathias,Kenji Matsumoto,Hamdi Mbarek,Wendy L. McArdle,Mads Melbye,Erik Melén,Deborah A. Meyers,Sven Michel,Hamida Mohamdi,Arthur W. Musk,Rachel A. Myers,Maartje A.E. Nieuwenhuis,Emiko Noguchi,George T. O'Connor,Ludmila M. Ogorodova,Cameron D. Palmer,Aarno Palotie,Julie E. Park,Craig E. Pennell,Göran Pershagen,Alexey Polonikov,Dirkje S. Postma,Nicole Probst-Hensch,V. P. Puzyrev,Benjamin A. Raby,Olli T. Raitakari,Adaikalavan Ramasamy,Stephen S. Rich,Colin F. Robertson,Isabelle Romieu,Muhammad T. Salam,Veikko Salomaa,Vivi Schlünssen,Robert A. Scott,P. A. Selivanova,Torben Sigsgaard,Angela Simpson,Valérie Siroux,Lewis J. Smith,Maria Solodilova,Marie Standl,Kari Stefansson,David P. Strachan,Bruno H. Stricker,Atsushi Takahashi,Philip J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Carla M. T. Tiesler,Dara G. Torgerson,Tatsuhiko Tsunoda,André G. Uitterlinden,Ralf J. P. van der Valk,Amaury Vaysse,Sailaja Vedantam,Andrea von Berg,Erika von Mutius,Judith M. Vonk,Johannes Waage,Nicholas J. Wareham,Scott T. Weiss,Wendy B. White,Magnus Wickman,Elisabeth Widen,Gonneke Willemsen,L. Keoki Williams,Inge M. Wouters,James J. Yang,Jing Hua Zhao,Miriam F. Moffatt,Carole Ober,Dan L. Nicolae +174 more