Journal ArticleDOI
Vitamin D Deficiency in Patients With Inflammatory Bowel Disease: Association With Disease Activity and Quality of Life
Alex Ulitsky,Ashwin N. Ananthakrishnan,Amar S. Naik,Sue Skaros,Yelena Zadvornova,David G. Binion,Mazen Issa +6 more
TLDR
Vitamin D deficiency is common in IBD and is independently associated with lower HRQOL and greater disease activity in CD and there is a need for prospective studies to assess this correlation and examine the impact of vitamin D supplementation on disease course.Abstract:
Background: Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aim of the study was to determine the prevalence and predictors of vitamin D deficiency in an IBD cohort. It was hypothesized that vitamin D deficiency is associated with increased disease activity and lower health-related quality of life (HRQOL). Methods: This was a retrospective cohort study. Harvey-Bradshaw index and ulcerative colitis disease activity index were used to assess disease activity. Short Inflammatory Bowel Disease Questionnaire scores were used to assess HRQOL. Multivariate logistic regression was used to identify independent predictors of vitamin D deficiency and its association with disease activity and HRQOL. Results: The study included 504 IBD patients (403 Crohn’s disease [CD] and 101 ulcerative colitis [UC]) who had a mean disease duration of 15.5 years in CD patients and 10.9 years in UC patients; 49.8% were vitamin D deficient, with 10.9% having severe deficiency. Vitamin D deficiency was associate...read more
Citations
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Journal ArticleDOI
Intestinal permeability – a new target for disease prevention and therapy
Stephan C. Bischoff,Giovanni Barbara,Wim A. Buurman,Theo Ockhuizen,Jörg-Dieter Schulzke,Matteo Serino,Herbert Tilg,Alastair J.M. Watson,Jerry M. Wells +8 more
TL;DR: Intestinal permeability, which is a feature of intestinal barrier function, is increasingly recognized as being of relevance for health and disease, and therefore, this topic warrants more attention.
Journal ArticleDOI
ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications
Christian Maaser,Andreas Sturm,Stephan R. Vavricka,Torsten Kucharzik,Gionata Fiorino,Vito Annese,Emma Calabrese,Daniel C. Baumgart,Dominik Bettenworth,Paula Borralho Nunes,Johan Burisch,Fabiana Castiglione,Rami Eliakim,Pierre Ellul,Yago Gonzalez-Lama,Hannah Gordon,Steve Halligan,Konstantinos Katsanos,Uri Kopylov,Paulo Gustavo Kotze,Eduards Krustins,Andrea Laghi,Jimmy K. Limdi,Florian Rieder,Jordi Rimola,Stuart A. Taylor,Damian Tolan,Patrick F. van Rheenen,Bram Verstockt,Jaap Stoker +29 more
TL;DR: Christian Maaser, a Andreas Sturm,b Stephan R. Vavricka,c Torsten Kucharzik,d Gionata Fiorino,e Vito Annese,f Emma Calabrese,f Daniel C. Baumgart,h Dominik Bettenworth,i Paula Borralho Nunes,j, Johan Burisch,k, Fabiana Castiglione,l Rami Eliakim,m Pierre Ellul,n Yago Gonz
Journal ArticleDOI
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.
Roger Bouillon,Claudio Marcocci,Geert Carmeliet,Daniel D. Bikle,John H. White,Bess Dawson-Hughes,Paul Lips,Craig F Munns,Craig F Munns,Marise Lazaretti-Castro,Andrea Giustina,John P. Bilezikian +11 more
TL;DR: There is a need for continued ongoing and future basic and clinical studies to better define whether vitamin D status can be optimized to improve many aspects of human health, and what is plausible regarding the health effects of vitamin D.
Journal ArticleDOI
Higher Predicted Vitamin D Status Is Associated With Reduced Risk of Crohn's Disease
Ashwin N. Ananthakrishnan,Hamed Khalili,Leslie M. Higuchi,Ying Bao,Joshua R. Korzenik,Edward Giovannucci,James M. Richter,Charles S. Fuchs,Charles S. Fuchs,Andrew T. Chan,Andrew T. Chan +10 more
TL;DR: Higher predicted plasma levels of 25(OH)D significantly reduce the risk for incident CD and nonsignificant reduction in UC in women, and there was a significant inverse association between dietary and supplemental vitamin D and UC.
Journal ArticleDOI
Vitamin D and inflammatory diseases
Kai Yin,Devendra K. Agrawal +1 more
TL;DR: The potential mechanisms of vitamin D in regulating immune/inflammatory responses in inflammatory diseases are discussed and a pleiotropic role in the pathogenesis of the diseases is considered.
References
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Journal ArticleDOI
The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications
TL;DR: Key issues that have emerged from discussions of the Montreal Working Party are highlighted and the relevance to clinical practice and research activities are highlighted.
Journal ArticleDOI
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Heike A. Bischoff-Ferrari,Edward Giovannucci,Walter C. Willett,Thomas Dietrich,Bess Dawson-Hughes +4 more
TL;DR: Evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density, lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer suggests that an increase in the currently recommended intake of vitamin D is warranted.
Journal ArticleDOI
Estimates of optimal vitamin D status
Bess Dawson-Hughes,Robert P. Heaney,Michael F. Holick,Paul Lips,Pierre J. Meunier,Reinhold Vieth,Reinhold Vieth +6 more
TL;DR: Based on the available evidence, it is believed that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture.
Journal ArticleDOI
Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
TL;DR: The results of this study suggest that high circulating levels of vitamin D are associated with a lower risk of multiple sclerosis.
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