1,25-Dihydroxycholecalciferol Prevents and Ameliorates Symptoms of Experimental Murine Inflammatory Bowel Disease
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TLDR
The vitamin D hypothesis was tested in an experimental animal model of inflammatory bowel disease (IBD) and it was found that supplementation with vitamin D significantly blocked the progression and ameliorated symptoms of IBD in IL-10 KO mice with already established IBD.Abstract:
Anecdotal data suggest that the amount of vitamin D available in the environment either from sunshine exposure or diet may be an important factor affecting the development of inflammatory bowel disease (IBD) in humans. We tested the vitamin D hypothesis in an experimental animal model of IBD. Interleukin (IL)-10 knockout (KO) mice, which spontaneously develop symptoms resembling human IBD, were made vitamin D deficient, vitamin D sufficient or supplemented with active vitamin D (1,25-dihydroxycholecalciferol). Vitamin D-deficient IL-10 KO mice rapidly developed diarrhea and a wasting disease, which induced mortality. In contrast, vitamin D-sufficient IL-10 KO mice did not develop diarrhea, waste or die. Supplementation with 50 IU of cholecalciferol (5.0 microgram/d) or 1, 25-dihydroxycholecalciferol (0.005 microgram/d) significantly (P < 0. 05) ameliorated symptoms of IBD in IL-10 KO mice. 1, 25-Dihydroxycholecalciferol treatment (0.2 microgram/d) for as little as 2 wk blocked the progression and ameliorated (P < 0.05) symptoms in IL-10 KO mice with already established IBD.read more
Citations
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Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease
TL;DR: Maintaining blood concentrations of 25-hydroxyvitamin D above 80 nmol/L (approximately 30 ng/mL) not only is important for maximizing intestinal calcium absorption but also may be important for providing the extrarenal 1alpha-hydroxylase that is present in most tissues to produce 1,25-dihydroxyv vitamin D3.
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Overview of general physiologic features and functions of vitamin D
TL;DR: An overview of the physiologic, endocrinologic, and molecular biologic characteristics of vitamin D is provided and information on new selective analogs of 1alpha,25-dihydroyvitamin D3 for therapy is provided.
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High prevalence of vitamin D inadequacy and implications for health.
TL;DR: The purposes of this article are to examine the prevalence of vitamin D inadequacy and to review the potential implications for skeletal and extraskeletal health.
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Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Roger Bouillon,Geert Carmeliet,Lieve Verlinden,Evelyne van Etten,Annemieke Verstuyf,Hilary F. Luderer,Liesbet Lieben,Chantal Mathieu,Marie B. Demay +8 more
TL;DR: The precise mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D], can now be better evaluated by critical analysis of mice with engineered deletion of the Vitamin D receptor (VDR).
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Vitamin effects on the immune system: vitamins A and D take centre stage
TL;DR: The current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, and the production of specific antibody isotypes and regulation of the immune response are presented.
References
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Interleukin-10-deficient mice develop chronic enterocolitis
TL;DR: The results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract.
Book
Vitamin D
TL;DR: In what case do you like reading so much? What about the type of the vitamin d the calcium homeostatic steroid hormone book? The needs to read? Well, everybody has their own reason why should read some books as discussed by the authors.
Journal ArticleDOI
A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
Hervé Groux,Anne O'Garra,M. Bigler,Matthieu Rouleau,Svetlana Antonenko,Jan E. de Vries,Maria Grazia Roncarolo +6 more
TL;DR: It is shown that chronic activation of both human and murine CD4+T cells in the presence of interleukin (IL)-10 gives rise to CD4-T-cell clones with low proliferative capacity, producing high levels ofIL-10, low levels of IL-2 and no IL-4.
Journal ArticleDOI
1,25-dihydroxyvitamin D3 receptors in human leukocytes
TL;DR: A 1,25-dihydroxyvitamin D3 receptor macromolecule was detected in peripheral mononuclear leukocytes from normal humans and was present in established lines of malignant B, T, and non-B, non-T human lymphocytes, as well as in T and B lymphocytes obtained fromnormal humans and activated in vitro.
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