Higher Predicted Vitamin D Status Is Associated With Reduced Risk of Crohn's Disease
Ashwin N. Ananthakrishnan,Hamed Khalili,Leslie M. Higuchi,Ying Bao,Joshua R. Korzenik,Edward Giovannucci,James M. Richter,Charles S. Fuchs,Charles S. Fuchs,Andrew T. Chan,Andrew T. Chan +10 more
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TLDR
Higher predicted plasma levels of 25(OH)D significantly reduce the risk for incident CD and nonsignificant reduction in UC in women, and there was a significant inverse association between dietary and supplemental vitamin D and UC.About:
This article is published in Gastroenterology.The article was published on 2012-03-01 and is currently open access. It has received 379 citations till now. The article focuses on the topics: vitamin D deficiency & Vitamin D and neurology.read more
Citations
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Journal ArticleDOI
Epidemiology and risk factors for IBD
TL;DR: Data support an association between smoking and Crohn's disease whereas smoking cessation, but not current smoking, is associated with an increased risk of ulcerative colitis.
Journal ArticleDOI
Understanding and Preventing the Global Increase of Inflammatory Bowel Disease
Gilaad G. Kaplan,Siew C. Ng +1 more
TL;DR: This work presents a long-term plan to develop interventions that slow or stop the global increase in the incidence of IBD.
Journal ArticleDOI
Sunlight and Vitamin D: A global perspective for health
TL;DR: A three-part strategy of increasing food fortification programs with vitamin D, sensible sun exposure recommendations and encouraging ingestion of a vitamin D supplement when needed should be implemented to prevent global vitamin D deficiency and its negative health consequences.
Journal ArticleDOI
Environmental triggers in IBD: a review of progress and evidence.
Ashwin N. Ananthakrishnan,Charles N. Bernstein,Dimitrios Iliopoulos,Andrew J. Macpherson,Markus F. Neurath,Raja Affendi Raja Ali,Stephan R. Vavricka,Claudio Fiocchi +7 more
TL;DR: Environmental factors add a substantial level of complexity to the understanding of IBD pathogenesis but also promote the fundamental notion that complex diseases such as IBD require complex therapies that go well beyond the current single-agent treatment approach.
Journal ArticleDOI
Geographical variability and environmental risk factors in inflammatory bowel disease
Siew C. Ng,Charles N. Bernstein,Morten H. Vatn,Peter L. Lakatos,Edward V. Loftus,Curt Tysk,Colm O'Morain,Bjørn Moum,Jean-Frederic Colombel +8 more
TL;DR: The present review aims to provide an update of the literature exploring geographical variability in IBD and to explore the environmental risk factors that may account for this variability.
References
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Journal ArticleDOI
Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
Journal ArticleDOI
Unravelling the pathogenesis of inflammatory bowel disease
TL;DR: Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation as mentioned in this paper, which have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis.
Journal ArticleDOI
Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences
TL;DR: Differences in incidence across age, time, and geographic region suggest that environmental factors significantly modify the expression of Crohn's disease and ulcerative colitis.
Journal ArticleDOI
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
Andre Franke,Dermot P.B. McGovern,Jeffrey C. Barrett,Kai Wang,Graham L. Radford-Smith,Tariq Ahmad,Charlie W. Lees,Tobias Balschun,James Lee,Rebecca L. Roberts,Carl A. Anderson,Joshua C. Bis,Suzanne Bumpstead,David Ellinghaus,Eleonora M. Festen,Michel Georges,Todd Green,Talin Haritunians,Luke Jostins,Anna Latiano,Christopher G. Mathew,Grant W. Montgomery,Natalie J. Prescott,Soumya Raychaudhuri,Jerome I. Rotter,Philip Schumm,Yashoda Sharma,Lisa A. Simms,Kent D. Taylor,David C. Whiteman,Cisca Wijmenga,Robert N. Baldassano,Murray L. Barclay,Theodore M. Bayless,Stephan Brand,Carsten Büning,Albert Cohen,Jean Frederick Colombel,Mario Cottone,Laura Stronati,Ted Denson,Martine De Vos,Renata D'Incà,Marla Dubinsky,Cathryn Edwards,Timothy H. Florin,Denis Franchimont,Richard B. Gearry,Jürgen Glas,Jürgen Glas,Jürgen Glas,André Van Gossum,Stephen L. Guthery,Jonas Halfvarson,Hein W. Verspaget,Jean-Pierre Hugot,Amir Karban,Debby Laukens,Ian C. Lawrance,Marc Lémann,Arie Levine,Cécile Libioulle,Edouard Louis,Craig Mowat,William G. Newman,Julián Panés,Anne M. Phillips,Deborah D. Proctor,Miguel Regueiro,Richard K Russell,Paul Rutgeerts,Jeremy D. Sanderson,Miquel Sans,Frank Seibold,A. Hillary Steinhart,Pieter C. F. Stokkers,Leif Törkvist,Gerd A. Kullak-Ublick,David C. Wilson,Thomas D. Walters,Stephan R. Targan,Steven R. Brant,John D. Rioux,Mauro D'Amato,Rinse K. Weersma,Subra Kugathasan,Anne M. Griffiths,John C. Mansfield,Severine Vermeire,Richard H. Duerr,Mark S. Silverberg,Jack Satsangi,Stefan Schreiber,Judy H. Cho,Vito Annese,Hakon Hakonarson,Mark J. Daly,Miles Parkes +97 more
TL;DR: A meta-analysis of six Crohn's disease genome-wide association studies and a series of in silico analyses highlighted particular genes within these loci implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP.
Journal ArticleDOI
Vitamin D Status: Measurement, Interpretation, and Clinical Application
TL;DR: The goal should be to maintain both children and adults at a level >30 ng/mL to take full advantage of all the health benefits that vitamin D provides.
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