Vitamin D Status and the Host Resistance to Infections: What It Is Currently (Not) Understood.
TLDR
This comprehensive review updates the current understanding regarding ways in which it is believed that vitamin D regulates responsiveness of the immune system and how serum status modulates the host defense against pathogens.About:
This article is published in Clinical Therapeutics.The article was published on 2017-05-01 and is currently open access. It has received 57 citations till now. The article focuses on the topics: vitamin D deficiency & Vitamin D and neurology.read more
Citations
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Journal ArticleDOI
Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths.
William B. Grant,Henry Lahore,Sharon L. McDonnell,Carole A. Baggerly,Christine French,Jennifer L. Aliano,Harjit Pal Bhattoa +6 more
TL;DR: Evidence supporting the role of vitamin D in reducing risk of COVID-19 includes that the outbreak occurred in winter, a time when 25-hydroxyvitamin D concentrations are lowest; that the number of cases in the Southern Hemisphere near the end of summer are low; that vitamin D deficiency has been found to contribute to acute respiratory distress syndrome; and that case-fatality rates increase with age and with chronic disease comorbidity.
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Role of vitamin D in preventing of COVID-19 infection, progression and severity.
TL;DR: There not enough evidence on the association between vitamin D levels and COVID-19 severity and mortality is found, and people who are at higher risk of vitamin D deficiency during this global pandemic should consider taking vitamin D supplements to maintain the circulating 25(OH)D in the optimal levels.
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Vitamin D's Effect on Immune Function.
TL;DR: In this review, the attention is shifted towards the importance of the extra-skeletal effects of vitamin D, with special emphasis on the immune system.
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Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity
TL;DR: The evidence seems strong enough that people and physicians can use or recommend vitamin D supplements to prevent or treat COVID-19 in light of their safety and wide therapeutic window.
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Interventions to restore appropriate immune function in the elderly
TL;DR: The aim of improving immune function in older individuals may be achieved through considering a therapeutic approach to rejuvenate, stimulate or support the indigenous immune system to perform in a more optimal manner.
References
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Journal ArticleDOI
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Heike A. Bischoff-Ferrari,Edward Giovannucci,Walter C. Willett,Thomas Dietrich,Bess Dawson-Hughes +4 more
TL;DR: Evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density, lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer suggests that an increase in the currently recommended intake of vitamin D is warranted.
Journal ArticleDOI
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Adrian R. Martineau,David A. Jolliffe,Richard Hooper,Lauren Greenberg,John F. Aloia,Peter Bergman,Gal Dubnov-Raz,Susanna Esposito,Davaasambuu Ganmaa,Adit A. Ginde,Emma C Goodall,Cameron C. Grant,Chris Griffiths,Wim Janssens,Ilkka Laaksi,Semira Manaseki-Holland,David T. Mauger,David R. Murdoch,Rachel E. Neale,Judy R. Rees,Steve Simpson,Iwona Stelmach,Geeta Trilok Kumar,Mitsuyoshi Urashima,Carlos A. Camargo +24 more
TL;DR: Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall and patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.
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Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial
Kerrie M. Sanders,Amanda L Stuart,Elizabeth A. Williamson,Julie A. Simpson,Mark A. Kotowicz,Doris Young,Geoffrey C. Nicholson +6 more
TL;DR: Among older community-dwelling women, annual oral administration of high-dose cholecalciferol resulted in an increased risk of falls and fractures.
Journal ArticleDOI
Vitamin D Metabolism, Mechanism of Action, and Clinical Applications
TL;DR: Different aspects of vitamin D metabolism, mechanism of action, and clinical application are examined, including ligand for the vitamin D receptor (VDR), a transcription factor, binding to sites in the DNA called vitamin D response elements (VDREs).
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Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation
TL;DR: It is found that 1,25(OH)2D3 may play an important role in the maintenance of B cell homeostasis and that the correction of vitamin D deficiency may be useful in the treatment of B Cell-mediated autoimmune disorders.
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Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
Adrian R. Martineau,David A. Jolliffe,Richard Hooper,Lauren Greenberg,John F. Aloia,Peter Bergman,Gal Dubnov-Raz,Susanna Esposito,Davaasambuu Ganmaa,Adit A. Ginde,Emma C Goodall,Cameron C. Grant,Chris Griffiths,Wim Janssens,Ilkka Laaksi,Semira Manaseki-Holland,David T. Mauger,David R. Murdoch,Rachel E. Neale,Judy R. Rees,Steve Simpson,Iwona Stelmach,Geeta Trilok Kumar,Mitsuyoshi Urashima,Carlos A. Camargo +24 more