Vitamins C and E to prevent complications of pregnancy-associated hypertension
James M. Roberts,Leslie Myatt,Catherine Y. Spong,Elizabeth Thom,John C. Hauth,Kenneth J. Leveno,Gail D. Pearson,Ronald J. Wapner,Michael W. Varner,John M. Thorp,Brian M. Mercer,Alan M. Peaceman,Susan M. Ramin,Marshall W. Carpenter,Philip Samuels,Anthony Sciscione,Margaret Harper,Wendy J. Smith,George R. Saade,Yoram Sorokin,Garland B. Anderson +20 more
TLDR
Vitamin C and E supplementation initiated in the 9th to 16th week of pregnancy in an unselected cohort of low-risk, nulliparous women did not reduce the rate of adverse maternal or perinatal outcomes related to pregnancy-associated hypertension.Abstract:
Background Oxidative stress has been proposed as a mechanism linking the poor placental perfusion characteristic of preeclampsia with the clinical manifestations of the disorder. We assessed the effects of antioxidant supplementation with vitamins C and E, initiated early in pregnancy, on the risk of serious adverse maternal, fetal, and neonatal outcomes related to pregnancy-associated hypertension. Methods We conducted a multicenter, randomized, double-blind trial involving nulliparous women who were at low risk for preeclampsia. Women were randomly assigned to begin daily supplementation with 1000 mg of vitamin C and 400 IU of vitamin E or matching placebo between the 9th and 16th weeks of pregnancy. The primary outcome was severe pregnancy-associated hypertension alone or severe or mild hypertension with elevated liver-enzyme levels, thrombocytopenia, elevated serum creatinine levels, eclamptic seizure, medically indicated preterm birth, fetal-growth restriction, or perinatal death. Results A total of ...read more
Citations
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The effects of oxidative stress on female reproduction: a review
TL;DR: The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success.
Journal ArticleDOI
Preeclampsia, a Disease of the Maternal Endothelium The Role of Antiangiogenic Factors and Implications for Later Cardiovascular Disease
TL;DR: Preeclampsia is a systemic vascular disorder that may also affect the liver and the brain in the mothers and is named not only for the liver involvement, but also for the disorder of the coagulation system that develops.
Journal ArticleDOI
Preeclampsia: Pathophysiology, Challenges, and Perspectives
Sarosh Rana,Elizabeth R. Lemoine,Elizabeth R. Lemoine,Joey P. Granger,S. Ananth Karumanchi,S. Ananth Karumanchi +5 more
TL;DR: The current evidence for the role of abnormal placentation and therole of placental factors such as the antiangiogenic factor, sFLT1 (soluble fms-like tyrosine kinase 1) in the pathogenesis of the maternal syndrome of preeclampsia is discussed.
Journal ArticleDOI
Vitamins C and E: beneficial effects from a mechanistic perspective.
Maret G. Traber,Jan F. Stevens +1 more
TL;DR: Mechanism-based effects of vitamin C and E supplementation on biomarkers and on clinical outcomes from randomized, placebo-controlled trials are emphasized in this review.
Journal ArticleDOI
Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies
TL;DR: A practical evidence based list of clinical risk factors that can be assessed by a clinician at ≤16 weeks’ gestation to estimate a woman’s risk of pre-eclampsia and the use of aspirin prophylaxis in pregnancy is developed.
References
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Journal ArticleDOI
Latest advances in understanding preeclampsia.
TL;DR: Recent work on the causes of preeclampsia is summarized, which reveals a new mode of maternal immune recognition of the fetus, relevant to the condition, and circulating factors derived from the placenta are now better understood.
Journal ArticleDOI
Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial
Lucy C Chappell,Paul T. Seed,Annette Briley,Frank J. Kelly,Rosalind Lee,Beverley J. Hunt,Kiran Parmar,Susan Bewley,Andrew Shennan,Philip J. Steer,Lucilla Poston +10 more
TL;DR: Multicentre trials are needed to show whether vitamin supplementation affects the occurrence of pre-eclampsia in low-risk women and to confirm the results in larger groups of high- risk women from different populations.
Journal ArticleDOI
Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial.
TL;DR: Concomitant supplementation with vitamin C and vitamin E does not prevent pre-eclampsia in women at risk, but does increase the rate of babies born with a low birthweight, and use of these high-dose antioxidants is not justified in pregnancy.
Journal ArticleDOI
Oxidative stress in the pathogenesis of preeclampsia.
TL;DR: A recurrent theme is that free radical reactions, promoted by "cross-talk" between the diseased placenta and maternal dyslipidemia, promote a vicious cycle of events that make cause and effect difficult to distinguish but likely contribute to the progression of preeclampsia.
Journal ArticleDOI
Placental oxidative stress: from miscarriage to preeclampsia.
Graham J. Burton,Eric Jauniaux +1 more
TL;DR: Miscarriage, missed miscarriage, and early- and late-onset preeclampsia represent a spectrum of disorders secondary to deficient trophoblast invasion, and high levels of oxidative stress in the periphery may induce formation of the chorion laeve.
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