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Waltzing transporters and 'the dance macabre' between humans and bacteria.
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Recent advances in the field of multidrug-resistance efflux pumps are reviewed and various approaches used in combating efflux-mediated resistance are described.Abstract:
Multidrug-resistance efflux pumps — in particular those belonging to the resistance-nodulation-cell-division (RND) family of transporters, with their unusually high degree of substrate promiscuity — significantly restrict the effectiveness of antibacterial therapy. Recent years have heralded remarkable insights into the structure and mechanisms of these fascinating molecular machines. Here, we review recent advances in the field and describe various approaches used in combating efflux-mediated resistance.read more
Citations
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Journal ArticleDOI
Origins and Evolution of Antibiotic Resistance
Julian Davies,Dorothy Davies +1 more
TL;DR: A review of antibiotic resistance development over the past half-century can be found in this article, with the oft-restated conclusion that it is time to act and to restore the therapeutic applications of antibiotics.
Journal ArticleDOI
Efflux-mediated drug resistance in bacteria: an update.
Xian-Zhi Li,Hiroshi Nikaido +1 more
TL;DR: The multifaceted implications of drug efflux transporters warrant novel strategies to combat multidrug resistance in bacteria.
Journal ArticleDOI
P-glycoprotein Inhibition for Optimal Drug Delivery.
TL;DR: A brief discussion on P-gp mediated drug transport and how it hinders the success of various therapies and various strategies used to tackle this curb in the field of drug delivery and targeting are discussed.
Journal ArticleDOI
The structural basis of calcium transport by the calcium pump
Claus Olesen,Martin Picard,Martin Picard,Anne-Marie Lund Winther,Anne-Marie Lund Winther,Claus Gyrup,J. Preben Morth,J. Preben Morth,Claus Oxvig,Jesper V. Møller,Jesper V. Møller,Poul Nissen,Poul Nissen +12 more
TL;DR: Functional studies and three new crystal structures of the rabbit skeletal muscle Ca2+-ATPase are presented, representing the phosphoenzyme intermediates associated withCa2+ binding, Ca2- translocation and dephosphorylation, that are based on complexes with a functional ATP analogue, beryllium fluoride and aluminium fluoride, respectively.
Journal ArticleDOI
Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It
TL;DR: Current advances in understanding the molecular bases of the low permeability barrier of Gram-negative pathogens, which is the major obstacle in discovery and development of antibiotics effective against such pathogens, are summarized.
References
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Journal ArticleDOI
Multidrug resistance in cancer: role of ATP–dependent transporters
TL;DR: The ability to predict and circumvent drug resistance is likely to improve chemotherapy, and it has become apparent that resistance exists against every effective drug, even the authors' newest agents.
Journal ArticleDOI
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
TL;DR: This review summarizes the development in the field since the previous review and begins to understand how this bilayer of the outer membrane can retard the entry of lipophilic compounds, owing to increasing knowledge about the chemistry of lipopolysaccharide from diverse organisms and the way in which lipopoly Saccharide structure is modified by environmental conditions.
Journal ArticleDOI
Targeting multidrug resistance in cancer
Gergely Szakács,Jill K. Paterson,Joseph A. Ludwig,Catherine Booth-Genthe,Michael M. Gottesman +4 more
TL;DR: Various approaches to combating multidrug-resistant cancer are described, including the development of drugs that engage, evade or exploit efflux by ABC transporters.
Journal Article
The major facilitator superfamily.
Milton H. Saier,Beatty Jt,André Goffeau,Kevin T. Harley,Wilbert H.M. Heijne,Huang Sc,Donald L. Jack,Jähn Ps,Lew K,Jun Liu,Stephanie S. Pao,Ian T. Paulsen,Tsai-Tien Tseng,Virk Ps +13 more
TL;DR: Evidence is presented substantiating the proposal that an internal tandem gene duplication event gave rise to a primordial MFS protein before divergence of the family members.
Journal ArticleDOI
Multidrug-resistance efflux pumps ? not just for resistance
TL;DR: Evidence is presented that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and it is proposed that these pumps therefore have greater clinical relevance than is usually attributed to them.