Journal ArticleDOI
Why the optimal requirement for Vitamin D3 is probably much higher than what is officially recommended for adults.
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TLDR
Health effects of Vitamin D beyond osteoporosis are mostly supported by the circumstantial evidence of epidemiologic studies and laboratory research, including prevention of cancer and the autoimmune diseases, insulin-dependent diabetes and multiple sclerosis.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2004-05-01. It has received 306 citations till now. The article focuses on the topics: Vitamin D and neurology & Cholecalciferol.read more
Citations
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Journal ArticleDOI
Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
Journal ArticleDOI
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes
Heike A. Bischoff-Ferrari,Edward Giovannucci,Walter C. Willett,Thomas Dietrich,Bess Dawson-Hughes +4 more
TL;DR: Evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density, lower-extremity function, dental health, and risk of falls, fractures, and colorectal cancer suggests that an increase in the currently recommended intake of vitamin D is warranted.
Journal ArticleDOI
High prevalence of vitamin D inadequacy and implications for health.
TL;DR: The purposes of this article are to examine the prevalence of vitamin D inadequacy and to review the potential implications for skeletal and extraskeletal health.
Journal ArticleDOI
Calcium plus vitamin D supplementation and the risk of fractures.
Rebecca D. Jackson,Andrea Z. LaCroix,Margery Gass,Robert B. Wallace,John A Robbins,Cora E. Lewis,Tamsen Bassford,Shirley A.A. Beresford,Henry R. Black,Patricia L. Blanchette,Denise E. Bonds,Robert L. Brunner,Robert G. Brzyski,Bette J. Caan,Jane A. Cauley,Rowan T. Chlebowski,Steven R. Cummings,Iris A. Granek,Jennifer Hays,Gerardo Heiss,Susan L. Hendrix,Barbara V. Howard,Judith Hsia,F. Allan Hubbell,Karen C. Johnson,Howard L. Judd,Jane Morley Kotchen,Lewis H. Kuller,Robert Langer,Norman L. Lasser,Marian C. Limacher,Shari E. Ludlam,JoAnn E. Manson,Karen L. Margolis,Joan McGowan,Judith K. Ockene,Mary Jo O'Sullivan,Lawrence S. Phillips,Ross L. Prentice,Gloria E. Sarto,Marcia L. Stefanick,Linda Van Horn,Jean Wactawski-Wende,Evelyn P Whitlock,Garnet L. Anderson,Annlouise R. Assaf,David H. Barad +46 more
TL;DR: Among healthy postmenopausal women, calcium with vitamin D supplementation resulted in a small but significant improvement in hip bone density, did not significantly reduce hip fracture, and increased the risk of kidney stones.
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Fracture Prevention With Vitamin D Supplementation: A Meta-analysis of Randomized Controlled Trials
Heike A. Bischoff-Ferrari,Walter C. Willett,John B. Wong,Edward Giovannucci,Thomas Dietrich,Bess Dawson-Hughes +5 more
TL;DR: Oral vitamin D supplementation between 700 to 800IU/d appears to reduce the risk of hip and any nonvertebral fractures in ambulatory or institutionalized elderly persons and an oral vitamin D dose of 400 IU/d is not sufficient for fracture prevention.
References
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Journal ArticleDOI
Vitamin D3 and calcium to prevent hip fractures in elderly women
Marie Claire Chapuy,Monique E. Arlot,François Duboeuf,Jacqueline Brun,Bridgette Crouzet,Simone Arnaud,Pierre D. Delmas,Pierre J. Meunier +7 more
TL;DR: The effects of supplementation with vitamin D3 (cholecalciferol) and calcium on the frequency of hip fractures and other nonvertebral fractures, identified radiologically, in 3270 healthy ambulatory women are studied.
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Effect of Calcium and Vitamin D Supplementation on Bone Density in Men and Women 65 Years of Age or Older
TL;DR: In men and women 65 years of age or older who are living in the community, dietary supplementation with calcium and vitamin D moderately reduced bone loss measured in the femoral neck, spine, and total body over the three-year study period and reduced the incidence of nonvertebral fractures.
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Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
Elina Hyppönen,Esa Läärä,Antti Reunanen,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Suvi M. Virtanen +5 more
TL;DR: Vitamin D supplementation was associated with a decreased frequency of type 1 diabetes when adjusted for neonatal, anthropometric, and social characteristics and Ensuring adequate vitamin D supplementation for infants could help to reverse the increasing trend in the incidence ofType 1 diabetes.
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2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary
Alexandra Papaioannou,Suzanne N Morin,Angela M. Cheung,Stephanie A. Atkinson,Jacques P. Brown,Sidney Feldman,David A. Hanley,Anthony B. Hodsman,Sophie A. Jamal,Stephanie M. Kaiser,Brent Kvern,Kerry Siminoski,William D. Leslie +12 more
TL;DR: There has been a paradigm shift in the prevention and treatment of osteoporosis and fractures, and the focus now is on preventing fragility fractures and their negative effects.
Journal ArticleDOI
Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety
TL;DR: The assembled data from many vitamin D supplementation studies reveal a curve for vitamin D dose versus serum 25-hydroxyvitamin D [25(OH)D] response that is surprisingly flat up to 250 microg (10000 IU) vitamin D/d.