Journal ArticleDOI
Zinc-related metallothionein metabolism in bovine pulmonary artery endothelial cells.
TLDR
It is concluded that extracellular zinc concentrations have relatively little impact on the cellular concentrations of MT and zinc of BPAEC in vitro, and hormones are likely candidates to be putative factors in serum.Citations
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Quinoline based reversible fluorescent ‘turn-on’ chemosensor for the selective detection of Zn2+: Application in living cell imaging and as INHIBIT logic gate
TL;DR: In this paper, a quinoline based reversible chemosensor (HL) for the efficient detection of Zn2+ has been developed, which exhibits an INHIBIT logic gate with EDTA as chemical inputs by monitoring the emission mode.
Journal ArticleDOI
Coumarin based dual switching fluorescent 'turn-on' chemosensor for selective detection of Zn2+ and HSO4−: an experimental and theoretical study
TL;DR: In this article, a highly sensitive and selective coumarin based fluorescence chemosensor (HL) for the efficient detection of Zn2+ and HSO4− over other ions has been developed.
Journal ArticleDOI
Expression, regulation and function of human metallothioneins in endothelial cells.
Iris A. Schulkens,Kitty C. M. Castricum,Ester M. Weijers,Pieter Koolwijk,Arjan W. Griffioen,Victor L. Thijssen +5 more
TL;DR: Findings provide a link between MTs and angiogenesis and find that the basal endothelial expression is restricted to MT1E, MT1X, MT2A, and MT3, which is related to decreased proliferation and sprouting and increased migration of human umbilical vein EC.
Journal ArticleDOI
Longitudinal changes in zinc transport kinetics, metallothionein, and zinc transporter expression in a blood-brain barrier model in response to a moderately excessive zinc environment
TL;DR: The BBB's response to a moderately high zinc environment was dynamic and involved multiple mechanisms, including increasing ZnT-2 transporters, presumably to sequester zinc into intracellular vesicles as a mechanism to protect the brain and to maintain brain zinc homeostasis.
Journal ArticleDOI
Coumarin based fluorescent ‘turn-on’ chemosensor for Zn2+: An experimental and theoretical study
TL;DR: A highly sensitive and selective coumarin based chemosensor for the efficient detection of Zn 2+ cation has been developed in a very facile and economically cheap route with an excellent yield as mentioned in this paper.
References
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PatentDOI
Measurement of protein using bicinchoninic acid
TL;DR: This new method maintains the high sensitivity and low protein-to-protein variation associated with the Lowry technique and demonstrates a greater tolerance of the bicinchoninate reagent toward such commonly encountered interferences as nonionic detergents and simple buffer salts.
Journal ArticleDOI
A simple, rapid, and sensitive DNA assay procedure.
C Labarca,Kenneth Paigen +1 more
TL;DR: The dissociation of chromatin is critical to accurate determinations of DNA in biological materials using this method, which can detect as little as 10 ng of DNA with rather unsophisticated instrumentation.
Journal ArticleDOI
Design and analysis of experiments in the animal and medical sciences
TL;DR: The design and analysis of experiments in the animal and medical sciences and the results show clear trends in animal studies and in the medical sciences are consistent with each other.
Journal ArticleDOI
Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.
TL;DR: It is proposed that ZnT‐1 transports zinc out of cells and that its absence accounts for the increased sensitivity of mutant cells to zinc toxicity.