Journal ArticleDOI
ZNF689 suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members.
Shuichiro Shigematsu,Shinji Fukuda,Hironao Nakayama,Hirofumi Inoue,Yoichi Hiasa,Morikazu Onji,Shigeki Higashiyama +6 more
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TLDR
The results indicate that ZNF689 blocks pro-apoptotic signaling by suppressing the Bak/Bax/Bid pathway, resulting in the progression of liver cancer and resistance to 5-FU.About:
This article is published in Experimental Cell Research.The article was published on 2011-08-01. It has received 16 citations till now. The article focuses on the topics: Viability assay & Gene knockdown.read more
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Role of microRNAs in the main molecular pathways of hepatocellular carcinoma.
Francesco Vasuri,Michela Visani,Giorgia Acquaviva,Thomas Brand,Michelangelo Fiorentino,Annalisa Pession,Giovanni Tallini,Antonia D'Errico,Dario de Biase +8 more
TL;DR: The most represented miRNA-regulated pathway in HCC is mTOR, but apoptosis, Wnt, JAK/STAT or MAPK pathways are also influenced by miRNA expression levels, and could thus be used in clinical practice as diagnostic, prognostic or therapeutic targets for HCC treatment.
Journal ArticleDOI
Novel tumor suppressor role of miRNA-876 in cholangiocarcinoma
Sarah Ursu,Shahana Majid,Caroline Garger,David de Semir,Vladimir Bezrookove,Pierre-Yves Desprez,Sean D. McAllister,Liliana Soroceanu,Mehdi Nosrati,Kidist K. Yimam,Assad Hassoun,Robert W. Osorio,Mohammed Kashani-Sabet,Altaf A. Dar +13 more
TL;DR: It is shown that miR-876 expression levels and copy number are significantly attenuated in the TCGA cohort of CCA tissue samples, and this study identifies BCL-XL as an actionable target, and suggests a potential therapeutic role for miR -876 in CCA.
Journal ArticleDOI
Comprehensive Characterization of the Human Endogenous Retrovirus HERV-K(HML-6) Group: Overview of Structure, Phylogeny, and Contribution to the Human Genome
TL;DR: The present work provides the first complete overview of the HML-6 elements in GRCh37(hg19), describing the structure, phylogeny, and genomic context of insertion of each locus, which allows a better understanding of the genetics of one of the most expressed HERV groups in the human genome.
Journal ArticleDOI
JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1
A Prakasam,Sampa Ghose,Natalia V. Oleinik,J R Bethard,Y K Peterson,Natalia I. Krupenko,Sergey A. Krupenko +6 more
TL;DR: In PC-3 prostate cancer cells, JNK1/2 phosphorylate Bid at Thr59 within the caspase cleavage site in response to ALDH1L1, which delays attainment of apoptosis, and allows the cell to evaluate the stress and make a decision regarding the response strategy.
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miRNA-339-5p Plays an Important Role in Invasion and Migration of Pancreatic Cancer Cells
TL;DR: In this article, the role of miRNA-339-5p in pancreatic cancer cell invasion and migration was investigated by microarray analysis, which showed that miR-3395p mRNA expression was significantly suppressed (P<0.001) in the PANC02-H7 exosome.
References
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Journal ArticleDOI
Management of hepatocellular carcinoma.
Jordi Bruix,Morris Sherman +1 more
TL;DR: The prevention of Cirrhosis can prevent the development of HCC and progression from chronic HCV infection to advanced fibrosis or cirrhosis may be prevented in 40% of patients who are sustained responders to new antiviral strategies, such as pegylated interferon and ribavirin.
Journal ArticleDOI
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Michael C. Wei,Michael C. Wei,Wei-Xing Zong,Emily H. Cheng,Tullia Lindsten,Vily Panoutsakopoulou,Andrea J. Ross,Kevin A. Roth,Grant R. MacGregor,Craig B. Thompson,Stanley J. Korsmeyer +10 more
TL;DR: In this article, the authors found that doubly deficient cells are resistant to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin.
Journal ArticleDOI
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
Tullia Lindsten,Andrea J. Ross,Ayala King,Wei-Xing Zong,Jeffrey C. Rathmell,Helena Shiels,Eugen Ulrich,Katrina G. Waymire,Patryce L. Mahar,Kenneth A. Frauwirth,Yifeng Chen,Michael C. Wei,Vicki M. Eng,David M. Adelman,M. Celeste Simon,Averil Ma,Jeffrey A. Golden,Gerard I. Evan,Stanley J. Korsmeyer,Grant R. MacGregor,Craig B. Thompson +20 more
TL;DR: Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis and are found to be developmentally normal and reproductively fit.
Journal ArticleDOI
Caspase-independent cell death.
Guido Kroemer,Seamus J. Martin +1 more
TL;DR: The contribution of caspases to cell death, either as upstream signals or as downstream effectors contributing to apoptotic morphology, is explored, as well as alternative strategies for cell death inhibition.
Journal ArticleDOI
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins.
TL;DR: Current knowledge of the functions and transcriptional as well as post-translational control mechanisms of BH3-only proteins is described.