Showing papers on "Benzoic acid published in 2003"
TL;DR: Ten compounds were found to be active against all four pathogens and are candidates for studies of activity in foods or for disinfections, and gallic acid was 20 times as active against S. enterica at pH 7.0 as it was at pH 3.7, suggesting that the ionization of its OH groups may enhance bactericidal activity.
258 citations
TL;DR: In this article, the degradation of toluene was carried out both in gas-solid and in liquid-solid regime by using polycrystalline samples of TiO2 Merck and Tetradecyldimethylamino-oxide.
Abstract: Photocatalytic degradation of toluene was carried out both in gas–solid and in liquid–solid regime by using polycrystalline samples of TiO2 Merck and TiO2 Degussa P25. For the gas–solid regime two types of continuous photoreactor were used, a fixed bed one of cylindrical shape and a Carberry type photoreactor, both irradiated by near-UV light. The inlet reacting mixture consisted of air containing toluene and water vapours. The influence of the gas flow rate and the presence of water vapour on the photocatalytic process was investigated. CO2 and benzaldehyde were the toluene degradation products detected in the gas phase by using TiO2 Merck. In the presence of water vapour this catalyst exhibited a stable activity, which greatly decreased in the absence of water vapour. On the contrary, TiO2 Degussa P25 produced CO2 and traces of benzaldehyde but it continuously deactivated even in the presence of water vapour. For the liquid–solid regime a batch photoreactor with immersed lamp was used. In order to increase the reaction rate, a zwitterionic surfactant, i.e. tetradecyldimethylamino-oxide, was added to the reacting mixture. A complete photo-oxidation of toluene was achieved after few hours of irradiation in the presence of both types of photocatalysts; longer irradiation times produced the photodegradation of surfactant. The main intermediates of toluene degradation were p-cresol and benzaldehyde while traces of pyrogallol and benzyl alcohol were also found. Benzoic acid, hydroquinone and trans, trans-muconic acid were detected only with TiO2 Merck. The reaction rate was higher in the presence of the surfactant suggesting that this compound acts as a sequestration agent. An FTIR study gave information on the role played by superficial hydroxyl groups both on the onset of activity and on the deactivation process. On the basis of photoreactivity results and of FTIR investigation the differences of activity and distribution and nature of toluene degradation products are critically discussed for the three reacting systems used.
161 citations
TL;DR: The atmospheric concentrations of 47 carboxylic acids in the semivolatile and particle phases are quantified in the Los Angeles area, as part of a larger study of the vapor-phase, semIVolatile, and particle-phase organic compounds.
Abstract: The atmospheric concentrations of 47 carboxylic acids in the semivolatile and particle phases are quantified in the Los Angeles area, as part of a larger study of the vapor-phase, semivolatile, and particle-phase organic compounds. Variations in the spatial and temporal distributions of acid concentrations are analyzed to determine whether atmospheric formation or primary emissions are responsible for the observed levels. Relatively low molecular weight aliphatic dicarboxylic acids (e.g., butanedioic acid, hexanedioic acid, and propanedioic acid) and some n-alkanoic acids (e.g., n-octanoic acid and n-nonanoic acid) are found at an offshore sampling location at levels comparable to urban area concentrations indicating that these compounds or their atmospheric precursors may be derived from long-range transport or natural background sources. Some aromatic carboxylic acids (e.g., benzoic acid and 1,2-benzenedicarboxylic acid) have spatial and temporal distributions suggesting that formation from anthropogenic emissions of gaseous precursors dominates their atmospheric concentrations. Additionally, the distributions of aliphatic carboxylic acid concentrations known to be emitted from primary sources (e.g., hexadecanoic acid and octadecanoic acid) are consistent with direct emissions as the dominant source of these compounds.
133 citations
TL;DR: The first examples of the use of racemic vinylaziridines in a Pd-catalyzed dynamic kinetic asymmetric transformation have been examined and the reactivity pattern is consistent with a Curtin-Hammett situation wherein the enantiodiscriminating event is the cyclization of a rapidly equilibrating dynamic pi-allyl palladium intermediate.
Abstract: The first examples of the use of racemic vinylaziridines in a Pd-catalyzed dynamic kinetic asymmetric transformation have been examined. Optimization studies of the Pd-catalyzed addition of vinylaziridines to isocyanates revealed that the chiral ligand between trans-1,2-diaminocyclohexane and 2-diphenylphosphino-1-naphthoic acid is superior to that involving 2-diphenylphosphino benzoic acid. Surprisingly, high ee's required the use of an acid whose pKa was about 4.7 ± 0.1 as a cocatalyst. Both acetic acid and hydroxybenzotriazole meet this requirement. Less electrophilic isocyanates (e.g., benzyl, p-methoxyphenyl) gave higher ee's than more electrophilic ones (phenyl or benzoyl). Both N-benzyl and N-arylaziridines react well to give good yields and ee's, whereas N-tosylaziridines gave lower ee's. A 1,1-disubstituted aziridine led to the formation of a tertiary C−N bond with ee's comparable to the formation of the secondary C−N bond. The products were easily reduced almost quantitatively to the sensitive i...
123 citations
TL;DR: Dietary phenolic acids showed diversified characteristics in their intestinal absorption, indicating that the transepithelial transport of CA was via the monocarboxylic acid transporter (MCT), and that the transport rate of GA was about 100 times lower than that of CA, suggesting the transport of GA to be via the paracellular pathway.
Abstract: The transepithelial transport of such common dietary phenolic acids as p-coumaric acid (CA) and gallic acid (GA) across Caco-2 cell monolayers was examined. CA transport was dependent on pH, and in a vectorial manner in the apical-basolateral direction. The permeation was concentration-dependent and saturable, the Michaelis constant and maximum velocity being 17.5 mM and 82.7 nmol min-1 (mg of protein)-1, respectively. Benzoic acid and acetic acid inhibited the permeation of CA. These results indicate that the transepithelial transport of CA was via the monocarboxylic acid transporter (MCT). On the other hand, the permeation of GA was not in a polarized manner, was independent of pH and linearly increased with increasing concentration of GA. The transport rate of GA was about 100 times lower than that of CA, suggesting the transepithelial transport of GA to be via the paracellular pathway. Dietary phenolic acids thus showed diversified characteristics in their intestinal absorption.
121 citations
TL;DR: These findings are significant for understanding biodegradation pathways of benzyl-containing quaternary ammonium compounds and proposed degradation pathway for BAC and related compounds.
Abstract: M . A . P A T R A U C H A N A N D P . J . O R I E L . 2003. Aims: The aim of this work was to study the biodegradation of benzyldimethylalkylammonium chloride (BAC) by Aeromonas hydrophila sp. K, an organism isolated from polluted soil and capable of utilizing BAC as sole source of carbon and energy. Methods and Results: High performance liquid chromatography and gas chromatography–mass spectrometry (GC-MS) analysis was used to study BAC degradation pathway. It was shown that during BAC biodegradation, formation of benzyldimethylamine, benzylmethylamine, benzylamine, benzaldehyde and benzoic acid occurred. Formation of benzyldimethylamine as the initial metabolite suggested that the cleavage of Calkyl-N bond occurred as the first step of BAC catabolism. Liberation of benzylmethylamine and benzylamine likely resulted from subsequent demethylation reactions, followed by deamination with formation of benzaldehyde. Benzaldehyde was rapidly converted into benzoic acid, which was further degraded. Conclusions: Aer. hydrophila sp. K is able to degrade BAC. A degradation pathway for BAC and related compounds is proposed. Significance and Impact of Study: These findings are significant for understanding biodegradation pathways of benzyl-containing quaternary ammonium compounds.
113 citations
TL;DR: The regression results showed that the TOC removal rates averaged over 30 min intervals did not illustrate significant dependence on TOC(0) and that I(mean) was more important in affecting the photocatalytic process within the ranges of the data examined.
112 citations
TL;DR: It is reported that the antibody-catalyzed water-oxidation process is capable of regioselectively converting antibody-bound benzoic acid into para-hydroxy benzosic acid as well as regioseslectively hydroxylating the 4-position of the phenyl ring of a single tryptophan residue located in the antibody molecule.
Abstract: Recent work in our laboratory showed that products formed by the antibody-catalyzed water-oxidation pathway can kill bacteria. Dihydrogen peroxide, the end product of this pathway, was found to be necessary, but not sufficient, for the observed efficiency of bacterial killing. The search for further bactericidal agents that might be formed along the pathway led to the recognition of an oxidant that, in its interaction with chemical probes, showed the chemical signature of ozone. Here we report that the antibody-catalyzed water-oxidation process is capable of regioselectively converting antibody-bound benzoic acid into para-hydroxy benzoic acid as well as regioselectively hydroxylating the 4-position of the phenyl ring of a single tryptophan residue located in the antibody molecule. We view the occurrence of these highly selective chemical reactions as evidence for the formation of a short-lived hydroxylating radical species within the antibody molecule. In line with our previously presented hypothesis according to which the singlet-oxygen ((1)O*(2)) induced antibody-catalyzed water-oxidation pathways proceeds via the formation of dihydrogen trioxide (H(2)O(3)), we now consider the possibility that the hydroxylating species might be the hydrotrioxy radical HO(3)*, and we point to the remarkable potential of this either H(2)O(3)- or O(3)-derivable species to act as a masked hydroxyl radical HO* in a biological environment.
110 citations
TL;DR: Benzoic acid is effective at lower concentrations than salicylic acid or its derivatives and is the most likely basic functional molecular structure imparting stress tolerance in plants.
Abstract: Benzoic acid, sulfosalicylic acid and methyl salicylic acid wereevaluated for their regulatory role in inducing multiple stress tolerance inbean (Phaseolus vulgaris cv Brown Beauty) and tomato(Lycopersicum esculentum cv Romano) plants. All threemolecules were effective in inducing tolerance to heat, drought and chillingstress similar to that reported previously for salicylic and acetylsalicylicacids. Benzoic acid is effective at lower concentrations than salicylic acid orits derivatives. The benzoic acid structural portion is common to all fivemolecules and is the most likely basic functional molecular structure impartingstress tolerance in plants.
110 citations
TL;DR: Various substrates for MCTs, such as benzoic acid and acetic acid, strongly inhibited the permeation of ferulic Acid, demonstrating that ferulic acid is obviously transported by MCT.
Abstract: Our previous study (Biosci. Biotechnol. Biochem., 66, 2449-2457 (2002)), suggested that ferulic acid was transported via a monocarboxylic acid transporter (MCT). Transepithelial transport of ferulic acid was examined in this study by directly measuring the rate of its transport across Caco-2 cell monolayers. Ferulic acid transport was dependent on pH, and in a vectorical way in the apical-basolateral direction. The permeation of ferulic acid was concentration-dependent and saturable; the Michaelis constant was 16.2 mM and the maximum velocity was 220.4 nmol min-1 (mg protein)-1. Various substrates for MCTs, such as benzoic acid and acetic acid, strongly inhibited the permeation of ferulic acid, demonstrating that ferulic acid is obviously transported by MCT. Antioxidative phenolic acid compounds from dietary sources like ferulic acid would be recognized and transported by MCT by intestinal absorption.
97 citations
TL;DR: Grafting of zirconium 1-propoxide on SBA-15 resulted in highly active catalysts for the MPV reduction as discussed by the authors, and they did not lose their activity in the presence of moisture or exposure to ambient atmosphere, making them easy to handle and reuse.
TL;DR: All these compounds showed fungicidal activity on TLC bioautography method at very low concentrations except elemicin.
TL;DR: In this article, an autoclave-based esterification of benzoic acid and substituted benzosic acids has been carried out over zeolite Hβ and HZSM5 using dimethyl carbonate as the methylating agent.
Abstract: Esterification of benzoic acid and substituted benzoic acids has been carried out efficiently over zeolite Hβ and HZSM5 in an autoclave using dimethyl carbonate (DMC) as the methylating agent. The wide applicability of this esterification method to esterify a wide range of aromatic carboxylic acids has been demonstrated. This method is a viable and safe alternative to other esterification processes, involving harmful alkylating agents and chemicals. Strong acid sites are responsible for the reaction. The reaction proceeds inside as well as outside the pores of the zeolites. The pore architecture of the zeolites and mass transfer limitations come into play only when the molecular diameter of the reactant molecules is greater than the pore size of the zeolites. Kinetic study shows that the reaction is first-order with respect to acid concentration.
TL;DR: In this article, various tertiary benzanilide derivatives were effectively synthesized from substituted benzoic acid and N-monoalkylated aniline using dichlorotriphenylphosphorane in chloroform.
TL;DR: In this article, the effect of electron-withdrawing substituents (bromo-, chloro-, and fluoro-) and ring position (ortho-, meta- and para-) on the response of a traditional deprotonated molecular ion ([M-H]-) and a sodium-bridged dimer ion ([2M-2 H+Na]-) was investigated by flow injection analysis in the negative ionization mode of electrospray ionization mass spectrometry.
TL;DR: In this paper, the chemical behavior of aromatic carboxylic acids in water at elevated temperatures has implications for industrial chemistry, fuel processing and waste treatment processes, and the authors investigated the hydrothermal reactions of six different aromatic CARO acids from 250-410°C at times up to 240 min.
Abstract: The chemical behavior of aromatic carboxylic acids in water at elevated temperatures has implications for industrial chemistry, fuel processing and waste treatment processes. Therefore, the hydrothermal reactions of six different aromatic carboxylic acids were investigated from 250–410 °C at times up to 240 min. Benzoic acid was the most stable of the six, showing negligible degradation after 1 h of hydrothermal treatment at 350 °C. Terephthalic acid, 2,6-naphthalene dicarboxylic acid and isophthalic acid were stable after 1 h at 300 °C, but they decarboxylated to form monoacids in 10–15% yields at 350 °C. Trimellitic anhydride decomposed completely after 30 min at 350 °C, but showed no appreciable decomposition after 30 min at 250 °C. Terephthalic acid and isophthalic acid were the main degradation products, but o-phthalic acid was also formed in small amounts at 350 °C. The o-phthalic acid conversion to benzoic acid was 73% after 60 min at 300 °C, but the diacid remained stable at 250 °C for 1 h. An autocatalytic kinetics model provided a good description of the trimellitic anhydride and terephthalic acid decomposition at 300 and 410 °C, respectively.
TL;DR: MnO-4 (04 mmol/g)-exchanged Mg-Al-hydrotalcite is an active and highly selective catalyst for the oxidation of benzyl alcohol to benzaldehyde by tert-butyl hydroperoxide under reflux in the absence of solvent as mentioned in this paper.
Abstract: MnO-4 (04 mmol/g)-exchanged Mg-Al-hydrotalcite is an active and highly selective catalyst for the oxidation of benzyl alcohol to benzaldehyde by tert-butyl hydroperoxide under reflux in the absence of solvent It also shows high activity for the oxidation of benzaldehyde to benzoic acid The higher the Mg/Al ratio, the higher is the catalytic activity (in both the reactions) and basicity of the hydrotalcite catalyst
TL;DR: The acid-promoted olefination of unactivated ketones with diazo reagents in the presence of triphenylphosphine can be catalyzed by the commercially available iron(III) porphyrin complex Fe(TPP)Cl.
TL;DR: First total synthesis of dehydroaltenusin, a natural enzyme inhibitor, is described and the synthetic sample was evaluated as a potent inhibitor against an eukaryotic DNA polymerase α.
TL;DR: Pseudomonas putida CSV86 cells transform 1- and 2-methylnaphthalene to 1-and-2-hydroxymethyl naphthalenes, which are further converted to the respective naphthoic acids due to the basal level expression and broad substrate specificity of the upper regulon enzymes.
Abstract: Pseudomonas putida CSV86 metabolizes 1- and 2-methylnaphthalene through distinct catabolic and detoxification pathways. In spite of the similarity in the steps involved in the methylnaphthalene detoxification and the toluene side-chain hydroxylation pathways, the strain failed to utilize toluene or xylenes. However, it could grow on benzyl alcohol, 2- and 4-hydroxybenzyl alcohol. Metabolic studies suggest that the benzyl alcohol metabolism proceeds via the benzaldehyde, benzoate, and catechol ortho-cleavage pathway, in contrast to the well established catechol meta-cleavage pathway. Carbon source-dependent enzyme activity studies suggest that the degradation of aromatic alcohol involves two regulons. Aromatic alcohol induces the upper regulon, which codes for aromatic alcohol- and aromatic aldehyde-dehydrogenase and converts alcohol into acid. The aromatic acid so generated induces the specific lower regulon and is metabolized via either the ortho- or the meta-cleavage pathway. CSV86 cells transform 1- and 2-methylnaphthalene to 1- and 2-hydroxymethyl naphthalene, which are further converted to the respective naphthoic acids due to the basal level expression and broad substrate specificity of the upper regulon enzymes.
TL;DR: In this article, the decarboxylation rates of aqueous benzoic acid and 12 mono-, di-, and trihydroxy derivatives of the acid were compared by using spectra from a flow reactor FTIR spectroscopy cell operating at 275 bar in the temperature range of 120−330 °C.
Abstract: The decarboxylation rates of aqueous benzoic acid and 12 mono-, di-, and trihydroxy derivatives of benzoic acid were compared by using spectra from a flow reactor FTIR spectroscopy cell operating at 275 bar in the temperature range of 120−330 °C Each compound was investigated at its natural pH and as the neutral acid (pH = 13−15) The decarboxylation reactions followed the first-order (or pseudo-first-order) rate law enabling the rate constants and corresponding Arrhenius parameters of the undissociated acids to be obtained Based on the half-lives of the reactions at 200 °C, the thermal stability of the OH substituted benzoic acids follow the order: 2,4,6 > 2,4 > 2,3,4 > 2,6 > 2,5 > 2,3 > 3,4,5 > 2 > 3,4 > 4 Solutions of 3,5-dihydroxybenzoic and 3-hydroxybenzoic acids and unsubstituted benzoic acid had the highest thermal stability, whereas no decarboxylation was observed up to 330 °C at a residence time of about 45s In general, the rate order is multiple ortho, para-OH substitution > ortho substit
TL;DR: In this article, the ring-opening polymerization of e-caprolactone (e-CL), initiated by carboxylic acids such as benzoic acid and chlorinated acetic acids under microwave irradiation, was investigated; with this method, no metal catalyst was necessary.
Abstract: The ring-opening polymerization of e-caprolactone (e-CL), initiated by carboxylic acids such as benzoic acid and chlorinated acetic acids under microwave irradiation, was investigated; with this method, no metal catalyst was necessary. The product was characterized as poly(e-caprolactone) (PCL) by 1 H NMR spectroscopy, Fourier transform infrared spectroscopy, ultraviolet spectroscopy, and gel permeation chromatography. The polymerization was significantly improved under microwave irradiation. The weight-average molecular weight (M w ) of PCL reached 44,800 g/mol, with a polydispersity index [weight-average molecular weight/number-average molecular weight (M w /M n )] of 1.6, when a mixture of e-CL and benzoic acid (25/1 molar ratio) was irradiated at 680 W for 240 min, whereas PCL with M w = 12,100 and M w /M n = 4.2 was obtained from the same mixture by a conventional heating method at 210 °C for 240 min. A degradation of the resultant PCL was observed during microwave polymerization with chlorinated acetic acids as initiators, and this induced a decrease in M w of PCL. However, the degradation was hindered by benzoic acid at low concentrations.
TL;DR: Investigation of the aerial parts of the medicinal plant Hypericum laricifolium led to the isolation of two new natural products, hentriacontanyl caffeate and nonacosanyl caffeates, which have anti-inflammatory effects.
Abstract: Investigation of the aerial parts of the medicinal plant Hypericum laricifolium led to the isolation of two new natural products, hentriacontanyl caffeate (1a), nonacosanyl caffeate (1b). In addition, stigmasterol, beta-sitosterol, 3-epi-betulinic acid (2), caffeic acid (3), ferulic acid, docosanol, p-hydroxybenzoic acid, 3,4-dimethoxy benzoic acid, quercetin (4), quercetin-3-O-galactoside (5), quercetin-3-O-rutinoside (6), quercetin-3-O-rhamnoside (7), quercetin-3-O-glucuronide (8) and shikimic acid were also isolated. The structures were determined by 1D- and 2D-NMR, mass spectrometry, and chemical transformations. The anti-inflammatory effects of the isolated compounds were discussed briefly.
TL;DR: The volatile extract composition of two different benzoin gums, Siam and Sumatra, were analyzed by GC-MS as mentioned in this paper, and the major components were benzyl benzoate (76.1-80.1%) for Siam, and styrene (2.3%), cinnamic acid (3.5%) and benzyl cinnamate(3.3%) for Sumatra.
Abstract: The volatile extract composition of two different benzoin gums, Siam and Sumatra, were analysed by GC-MS. Twenty components representing more than 99.1% of the oil from Siam and 29 components representing more than 97.4% of the oil from Sumatra were analysed. The major components were benzyl benzoate (76.1-80.1%) for the two oils and benzoic acid (12.5%), methyl benzoate (1.5%) and allyl benzoate (1.5%) for Siam, and styrene (2.3%), cinnamic acid (3.5%) and benzyl cinnamate (3.3%) for Sumatra. Volatile compounds of oils and crushed benzoins were also studied using solid-phase microextraction (SPME) employing carboxen/polydimethylsiloxane and carbowax/divinylbenzene fibres. Copyright © 2003 John Wiley & Sons, Ltd.
TL;DR: The regression equation based on the self-consistent thermochemical scale makes it possible to approximate the ability to solvate a drug substance in comparison with structure-relative substances.
Abstract: Purpose. To investigate the solution process of drug substances (exemplified by benzoic acid, BA, and acetylsalicylic acid, ASA), particularly the interrelation between enthalpic and entropic terms of Gibbs energy, in different solvents. To develop an approach for the estimation of standard solution enthalpies based on a self-consistent thermochemical scale.
TL;DR: This method was successfully applied for studying hydroxyl radical scavenging activities of Chinese herbs and it is testified that Apocynum Venetum L., Jinkgo bibola L., Morus alba L. and Rhododendron dauricum L. have strong hydroxym radical scaveniting activities.
Abstract: High-performance capillary electrophoresis (CE) with electrochemical detection (ED) was employed to determine hydroxyl radicals in the Fenton reaction. Hydroxyl radicals can react with salicylic acid to produce 2,3-dihydroxy benzoic acid and 2,5-dihydroxy benzoic acid, which can be analyzed by CE-ED. Based on this principle, hydroxyl radicals were determined indirectly. In a 20 mmol/L phosphate running buffer (pH 7.4), 2,3-dihydroxy benzoic acid and 2,5-dihydroxy benzoic acid would elute simultaneously from the capillary within 6 min. As the working electrode, a 300 microm diameter carbon-disk electrode exhibits good responses at +0.60 V (vs. SCE) for the two analytes. Peak currents of the two analytes are additive. Excellent linearity was obtained in the concentration range from 1.0x10(-3) mol/L to 5.0x10(-6) mol/L for 2,3-dihydroxy benzoic acid. The detection limit (S/N=3) was 2.0x10(-6) mol/L. This method was successfully applied for studying hydroxyl radical scavenging activities of Chinese herbs. It is testified that Apocynum Venetum L., Jinkgo bibola L., Morus alba L. and Rhododendron dauricum L. have strong hydroxyl radical scavenging activities.
TL;DR: Equipment for on-line coupled hot water extraction and supercritical water oxidation was constructed to extract polyaromatic hydrocarbons and toluene from sea sand followed by oxidation using hydrogen peroxide.
Patent•
14 Nov 2003
TL;DR: In this paper, an aqueous disinfecting solution, a concentrated version of the solution, and a dry powdered composition which may be dissolved in water to provide the solution are presented.
Abstract: An aqueous disinfecting solution, a concentrated version of the solution, and a dry powdered composition which may be dissolved in water to provide the solution. The solution has a pH of from 0.6 to 7 and comprises (a) hydrogen peroxide in a concentration of from 0.01 to 6% w/w; and (b) at least one component chosen from cyclic carboxylic acids and aromatic alcohols, in a concentration of from 0.01 to 10% w/w, all based on the total weight of the solution. The cyclic carboxylic acids are preferably 2-furan carboxylic acid, benzoic acid and salicylic acid and the aromatic alcohol is preferably benzyl alcohol. Furthermore, the solution may contain surfactants, corrosion inhibitors, hydrotropes, cation sequestering agents, hydrogen peroxide stabilizers, solvents, thickeners, skin conditioning agents, antifoams, and pH buffers.
TL;DR: Experiments performed using carboxylic acids other then benzoic acid and its derivatives show that this method is not limited to phenide anions and can be used for the generation of a much wider range of carbanions in the gas phase.
Abstract: Substituted benzoic acid anions undergo decarboxylation in the medium-pressure region of an electrospray ion source yielding in most cases the correspondingly substituted phenide anions in high yield. The location of the anionic center is specified by the position of the carboxylic group. The only exceptions are compounds with substituents containing acidic hydrogen atoms, like OH and NH2 groups. For such compounds, either an intra- or an intermolecular (mediated by the molecules of methanol or water) proton transfer from the more acidic position to the benzene ring is observed. The generated anions can be selected using the first quadrupole for studying their ion-molecule chemistry in the second quadrupole of a triple quadrupole mass spectrometer. Their reactions with CO2, O2, CH3COCH3 and CCl4 may serve as typical examples. The general applicability of this method for the generation of phenide anions has been confirmed on three different mass spectrometers. Experiments performed using carboxylic acids other then benzoic acid and its derivatives show that this method is not limited to phenide anions and can be used for the generation of a much wider range of carbanions in the gas phase. Copyright © 2003 John Wiley & Sons, Ltd.
TL;DR: In this paper, the effect of -COOH substituent on the copolymer structure is discussed and the spectral studies have revealed restricted conjugation along the polymer chain.