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Alvaro J. Romanha
Researcher at Oswaldo Cruz Foundation
Publications - 180
Citations - 7491
Alvaro J. Romanha is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Trypanosoma cruzi & Benznidazole. The author has an hindex of 47, co-authored 180 publications receiving 6983 citations. Previous affiliations of Alvaro J. Romanha include Universidade Federal de Juiz de Fora & Universidade Federal de Santa Catarina.
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Journal ArticleDOI
Strains and clones of Trypanosoma cruzi can be characterized by pattern of restriction endonuclease products of kinetoplast DNA minicircles.
TL;DR: It is shown that, from a given T. cruzi strain, clones with different biological properties can be isolated and identified by their restriction patterns.
Journal ArticleDOI
In vitro and in vivo experimental models for drug screening and development for Chagas disease
Alvaro J. Romanha,Solange L. de Castro,Maria de Nazaré Correia Soeiro,Joseli Lannes-Vieira,Isabela Ribeiro,André Talvani,Bernadette Bourdin,Bethania Blum,Bianca P. Olivieri,Carlos L. Zani,Carmenza Spadafora,Egler Chiari,Eric Chatelain,Gabriela Costa Chaves,José E. Calzada,Juan M. Bustamante,Lucio H. Freitas-Junior,Luz Romero,Maria Terezinha Bahia,Michel Lotrowska,Milena Botelho Pereira Soares,Sonia G. Andrade,Tanya Armstrong,Wim Degrave,Zilton A. Andrade +24 more
TL;DR: An in vitro and in vivo flowchart was designed to serve as a general and standardised protocol for screening potential drugs for the treatment of Chagas disease.
Journal ArticleDOI
The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases – Part I
Thomas J. Schmidt,Sami A. Khalid,Alvaro J. Romanha,T. Ma. Alves,Maique W. Biavatti,Reto Brun,FB Da Costa,S. L. De Castro,Vitor F. Ferreira,M. V. G. de Lacerda,João Henrique G. Lago,Leonor L. Leon,Norberto Peporine Lopes,R. C. das Neves Amorim,Michael Niehues,Ifedayo Victor Ogungbe,Adrian Martin Pohlit,Marcus Tullius Scotti,William N. Setzer,M. de N. C. Soeiro,M. Steindel,Andre G. Tempone +21 more
TL;DR: The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.
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Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-γ as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi.
André Talvani,André Talvani,Cristiana S Ribeiro,Julio Aliberti,Vladimir Michailowsky,Paula V.A. dos Santos,Silvane M. F. Murta,Alvaro J. Romanha,Igor C. Almeida,Joshua M. Farber,Joseli Lannes-Vieira,João Santana da Silva,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli +13 more
TL;DR: Results indicate that regulation of IFN-gamma and chemokine expression, associated with decreased tissue parasitism, may be largely responsible for the control of inflammation and immunopathology observed in the cardiac tissue of animals infected with T. cruzi.
Journal ArticleDOI
Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox
Silvane M. F. Murta,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,Zigman Brener,Alvaro J. Romanha +4 more
TL;DR: All 19 of zymodeme B were susceptible to the experimental treatment independent of their geographic origin and no correlation was observed between drug susceptibility and polymorphisms of rDNA and MEX.