A
Amanda L. Christie
Researcher at Harvard University
Publications - 50
Citations - 7580
Amanda L. Christie is an academic researcher from Harvard University. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 29, co-authored 49 publications receiving 6415 citations. Previous affiliations of Amanda L. Christie include AstraZeneca & Boston Children's Hospital.
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Journal ArticleDOI
Selective inhibition of BET bromodomains.
Panagis Filippakopoulos,Jun Qi,Sarah Picaud,Yao Shen,William B. Smith,Oleg Fedorov,Elizabeth M. Morse,T. Keates,Tyler T. Hickman,I. Felletar,Martin Philpott,Shonagh Munro,Michael R. McKeown,Yuchuan Wang,Amanda L. Christie,Nathan West,Michael J. Cameron,Brian E. Schwartz,Tom D. Heightman,Nicholas B. La Thangue,Christopher A. French,Olaf Wiest,Andrew L. Kung,Stefan Knapp,Stefan Knapp,James E. Bradner +25 more
TL;DR: A cell-permeable small molecule (JQ1) that binds competitively to acetyl-lysine recognition motifs, or bromodomains is reported, establishing proof-of-concept for targeting protein–protein interactions of epigenetic ‘readers’, and providing a versatile chemical scaffold for the development of chemical probes more broadly throughout the b romodomain family.
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SCF FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
Hiroyuki Inuzuka,Shavali Shaik,Ichiro Onoyama,Darning Gao,Alan Tseng,Richard S. Maser,Bo Zhai,Lixin Wan,Alejandro Gutierrez,Alan W. Lau,Yonghong Xiao,Amanda L. Christie,Jon C. Aster,Jeffrey Settleman,Steven P. Gygi,Andrew L. Kung,Thomas Look,Keiichi I. Nakayama,Ronald A. DePinho,Wenyi Wei +19 more
TL;DR: It is shown that the E3 ubiquitin ligase SCFFBW7 (a SKP1–cullin-1–F-box complex that contains FBW7 as the F-box protein) governs cellular apoptosis by targeting MCL1, a pro-survival BCL2 family member, for ubiquitylation and destruction in a manner that depends on phosphorylation by glycogen synthase kinase 3.
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Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma.
Yu-Tzu Tai,Patrick A. Mayes,Chirag Acharya,Mike Y Zhong,Michele Cea,Antonia Cagnetta,Jenny L Craigen,John Yates,Louise Gliddon,William E. Fieles,Bao Hoang,James Tunstead,Amanda L. Christie,Andrew L. Kung,Paul G. Richardson,Nikhil C. Munshi,Kenneth C. Anderson +16 more
TL;DR: It is demonstrated that GSK2857916 has potent and selective anti-MM activities via multiple cytotoxic mechanisms, providing a promising next-generation immunotherapeutic in this cancer.
Journal ArticleDOI
Mediator kinase inhibition further activates super-enhancer-associated genes in AML
Henry E. Pelish,Brian B. Liau,Ioana Nitulescu,Anupong Tangpeerachaikul,Zachary C. Poss,Diogo H. Da Silva,Brittany T. Caruso,Alexander Arefolov,Olugbeminiyi O Fadeyi,Amanda L. Christie,Karrie Du,Deepti Banka,E.V. Schneider,Anja Jestel,Ge Zou,Chong Si,Christopher C. Ebmeier,Roderick T. Bronson,Andrei V. Krivtsov,Andrew G. Myers,Nancy E. Kohl,Andrew L. Kung,Scott A. Armstrong,Madeleine E. Lemieux,Dylan J. Taatjes,Matthew D. Shair +25 more
TL;DR: It is shown that the Mediator-associated kinases cyclin-dependent kinase 8 (CDK8) and CDK19 restrain increased activation of key SE-associated genes in acute myeloid leukaemia (AML) cells.
Journal ArticleDOI
The requirement for cyclin D function in tumor maintenance.
Yoon Jong Choi,Xiaoyu Li,Per Hydbring,Takaomi Sanda,Takaomi Sanda,Joanna Stefano,Amanda L. Christie,Sabina Signoretti,Sabina Signoretti,A. Thomas Look,A. Thomas Look,Andrew L. Kung,Harald von Boehmer,Piotr Sicinski +13 more
TL;DR: Mice strains are engineered that allow acute and global ablation of individual D-cyclins in a living animal and inhibition of cyclin D-associated kinase activity represents a highly-selective anticancer strategy that specifically targets cancer cells without significantly affecting normal tissues.