A
Amy E. Pasquinelli
Researcher at University of California, San Diego
Publications - 75
Citations - 21378
Amy E. Pasquinelli is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Gene silencing & Argonaute. The author has an hindex of 36, co-authored 69 publications receiving 20002 citations. Previous affiliations of Amy E. Pasquinelli include University of Wisconsin-Madison & Harvard University.
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Journal ArticleDOI
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Brenda J. Reinhart,Frank J. Slack,Frank J. Slack,Michael Basson,Amy E. Pasquinelli,Bettinger Jc,Ann E. Rougvie,H R Horvitz,Gary Ruvkun +8 more
TL;DR: It is shown that let-7 is a heterochronic switch gene that encodes a temporally regulated 21-nucleotide RNA that is complementary to elements in the 3′ untranslated regions of the heteroch chronic genes lin-14, lin-28, Lin-41, lin -42 and daf-12, indicating that expression of these genes may be directly controlled by let- 7.
Journal ArticleDOI
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA.
Gyorgy Hutvagner,Juanita Mclachlan,Amy E. Pasquinelli,Eva Balint,Thomas Tuschl,Phillip D. Zamore +5 more
TL;DR: In Drosophila melanogaster a developmentally regulated precursor RNA is cleaved by an RNA interference-like mechanism to produce mature let-7 stRNA, which regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals.
Journal ArticleDOI
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
Amy E. Pasquinelli,Brenda J. Reinhart,Frank J. Slack,Mark Q. Martindale,Mitzi I. Kuroda,Betsy Maller,David C. Hayward,Eldon E. Ball,Bernard M. Degnan,Peter Müller,Jürg Spring,Ashok Srinivasan,Mark C. Fishman,John R. Finnerty,Joseph C. Corbo,Michael P. Levine,Patrick S. Leahy,Eric H. Davidson,Gary Ruvkun +18 more
TL;DR: Two small RNAs regulate the timing of Caenorhabditis elegans development and may control late temporal transitions during development across animal phylogeny.
Journal ArticleDOI
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
Alla Grishok,Amy E. Pasquinelli,Darryl Conte,Na Li,Susan Parrish,Ilho Ha,David L. Baillie,Andrew Fire,Gary Ruvkun,Craig C. Mello +9 more
TL;DR: It is shown that inactivation of genes related to RNAi pathway genes, a homolog of Drosophila Dicer (dcr-1), and two homologs of rde-1 (alg-1 and alg-2), cause heterochronic phenotypes similar to lin-4 and let-7 mutations.
Journal ArticleDOI
MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship
TL;DR: This work has shown that targets can reciprocally control the level and function of miRNAs, and this has important implications for the use of these RNAs in therapeutic settings.