Andri Manser

TL;DR: Current knowledge of how natural drive systems function, how drivers spread through natural populations, and the factors that limit their invasion are reviewed.

TL;DR: Simulations show that polyandry can explain the observed t dynamics, making it a biologically plausible explanation for low t frequencies in natural populations in general.

TL;DR: This paper showed that global distributions of 43 Drosophila species better match male-sterilizing, rather than lethal, temperatures than lethal temperatures, suggesting that species distributions may be determined by thermal limits to reproduction, not survival, meaning we may be underestimating the impacts of climate change for many organisms.

TL;DR: It is demonstrated that drive‐carrying males are substantially compromised in their sperm competitive ability, and direct experimental evidence that the mating system of a species can have important repercussions on the spread of drive genes over evolutionary relevant timescales is provided.

TL;DR: This review summarizes the current knowledge of drive resistance in both natural and synthetic gene drives and explores how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.