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Andy Menzies
Researcher at Wellcome Trust Sanger Institute
Publications - 10
Citations - 4197
Andy Menzies is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Genomics. The author has an hindex of 9, co-authored 10 publications receiving 3908 citations.
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Journal ArticleDOI
Patterns of somatic mutation in human cancer genomes
Christopher Greenman,Philip J. Stephens,Raffaella Smith,Gillian L. Dalgliesh,Christopher I. Hunter,Graham R. Bignell,Helen Davies,Jon W. Teague,Adam Butler,Claire Stevens,Sarah Edkins,Sarah O’Meara,Imre Vastrik,Esther Schmidt,Tim Avis,Syd Barthorpe,Gurpreet Bhamra,Gemma Buck,Bhudipa Choudhury,Jody Clements,Jennifer Cole,Ed Dicks,Simon A. Forbes,Kris Gray,Kelly Halliday,Rachel Harrison,Katy Hills,Jon Hinton,Andy Jenkinson,David T. Jones,Andy Menzies,Tatiana Mironenko,Janet Perry,Keiran Raine,Dave Richardson,Rebecca Shepherd,Alexandra Small,Calli Tofts,Jennifer Varian,Tony Webb,Sofie West,Sara Widaa,Andrew D. Yates,Daniel P. Cahill,David N. Louis,Peter Goldstraw,Andrew G. Nicholson,Francis Brasseur,Leendert H. J. Looijenga,Barbara L. Weber,Yoke Eng Chiew,Anna deFazio,Mel Greaves,Anthony R. Green,Peter J. Campbell,Ewan Birney,Douglas F. Easton,Georgia Chenevix-Trench,Min-Han Tan,Sok Kean Khoo,Bin Tean Teh,Siu Tsan Yuen,Suet Yi Leung,Richard Wooster,P. Andrew Futreal,Michael R. Stratton,Michael R. Stratton +66 more
TL;DR: More than 1,000 somatic mutations found in 274 megabases of DNA corresponding to the coding exons of 518 protein kinase genes in 210 diverse human cancers reveal the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated.
Journal ArticleDOI
Lung cancer: intragenic ERBB2 kinase mutations in tumours.
Philip J. Stephens,Christopher I. Hunter,Graham R. Bignell,Sarah Edkins,Helen Davies,Jon W. Teague,Claire Stevens,Sarah O’Meara,Raffaella Smith,Adrian Parker,Andy Barthorpe,Matthew J. Blow,Lisa Brackenbury,Adam Butler,Oliver Clarke,Jennifer Cole,Ed Dicks,Angus Dike,Anja Drozd,Ken Edwards,Simon A. Forbes,Rebecca Foster,Kristian Gray,Christopher Greenman,Kelly Halliday,Katy Hills,Vivienne Kosmidou,Richard Lugg,Andy Menzies,Janet Perry,Robert Petty,Keiran Raine,Lewis Ratford,Rebecca Shepherd,Alexandra Small,Yvonne Stephens,Calli Tofts,Jennifer Varian,Sofie West,Sara Widaa,Andrew D. Yates,Francis Brasseur,Colin Cooper,Adrienne M. Flanagan,Margaret A. Knowles,Suet Yi Leung,David N. Louis,Leendert H. J. Looijenga,Bruce Malkowicz,Marco A. Pierotti,Bin Teh,Georgia Chenevix-Trench,Barbara L. Weber,Siu Tsan Yuen,Grace Harris,Peter Goldstraw,Andrew G. Nicholson,P. Andrew Futreal,Richard Wooster,Michael R. Stratton,Michael R. Stratton +60 more
TL;DR: The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising targets for the design of antitumour therapies as mentioned in this paper.
X-Linked Protocadherin 19 Mutations Cause Female-Limited Epilepsy and Cognitive Impairment. Dibbens LM,
Geneviève Albouy,Annabelle Darsaud,S. Gais,Sterpenich,Gilles Vandewalle,Gustave Moonen,Evelyne Balteau,A. Luxen,Christophe Phillips,Tarpey Ps,Hynes K,Bayly Ma,IE Scheffer,Smith R,Bomar J,Sutton E,Vandeleur L,Shoubridge C,Sarah Edkins,Turner Sj,Claire Stevens,Tofts C,Cole J,Kelly Halliday,Lee R,West S,Sara Widaa,Wray P,Jon W. Teague,Ed Dicks,Andy Menzies,Andy Jenkinson,Rebecca Shepherd,Aziz Mazarib,Kivity S,Kim Hg,Paul Q. Thomas,E. Haan,Ryan S,McKee S,Michael R. Stratton,Mulley Jc,J Gecz +42 more
TL;DR: Seven protocadherin 19 (PCDH19) gene mutations in seven families with EFMR resulted in the introduction of a premature termination codon and two missense mutations were predicted to affect adhesiveness of PCDH19 through impaired calcium binding.
Journal ArticleDOI
Mutational signatures of ionizing radiation in second malignancies.
Sam Behjati,Gunes Gundem,David C. Wedge,David C. Wedge,Nicola D. Roberts,Patrick S. Tarpey,Susanna L. Cooke,Peter Van Loo,Peter Van Loo,Ludmil B. Alexandrov,Manasa Ramakrishna,Helen Davies,Serena Nik-Zainal,Claire Hardy,Calli Latimer,Keiran Raine,Lucy Stebbings,Andy Menzies,David T. Jones,Rebecca Shepherd,Adam Butler,Jon W. Teague,Mette Jorgensen,Bhavisha Khatri,Nischalan Pillay,Nischalan Pillay,Adam Shlien,P. Andrew Futreal,P. Andrew Futreal,Christophe Badie,Colin Cooper,Rosalind A. Eeles,Douglas F. Easton,Christopher S. Foster,David E. Neal,Daniel Brewer,Freddie C. Hamdy,Freddie C. Hamdy,Yong-Jie Lu,Andy G. Lynch,Charlie E. Massi,Anthony C. H. Ng,Hayley C. Whitaker,Yongwei Yu,Hongwei Zhang,Elizabeth Bancroft,Daniel M. Berney,Niedzica Camacho,Cathy Corbishley,Tokhir Dadaev,Nening Dennis,Tim Dudderidge,Sandra L. Edwards,Cyril Fisher,Jilur Ghori,Vincent J. Gnanapragasam,Christopher Greenman,Steve Hawkins,Steven Hazell,William J. Howat,Katalin Karaszi,Jonathan Kay,Zsofia Kote-Jarai,Barbara Kremeyer,Pardeep Kumar,Adam Lambert,Daniel Leongamornlert,Naomi Livni,Hayley J. Luxton,Lucy Matthews,Erik Mayer,Susan Merson,David Nicol,Chris Ogden,Sarah O’Meara,Gill Pelvender,Nimish Shah,Simon Tavaré,Sarah Thomas,Alan J. Thompson,Claire Verrill,Anne Y. Warren,Jorge Zamora,Ultan McDermott,G. Steven Bova,Andrea L. Richardson,Adrienne M. Flanagan,Adrienne M. Flanagan,Michael R. Stratton,Peter J. Campbell,Peter J. Campbell +90 more
TL;DR: Two signatures of somatic mutation characterize ionizing radiation exposure irrespective of tumour type, and a significant increase in balanced inversions in radiation-associated tumours is observed.