B
Baptiste Aussedat
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 25
Citations - 1104
Baptiste Aussedat is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Epitope & Antigen. The author has an hindex of 16, co-authored 25 publications receiving 939 citations. Previous affiliations of Baptiste Aussedat include Centre national de la recherche scientifique & Kettering University.
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Journal ArticleDOI
Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies
Mattia Bonsignori,Mattia Bonsignori,Edward F. Kreider,Daniela Fera,R. Ryan Meyerhoff,R. Ryan Meyerhoff,Todd Bradley,Todd Bradley,Kevin Wiehe,Kevin Wiehe,S. Munir Alam,S. Munir Alam,Baptiste Aussedat,William E. Walkowicz,Kwan-Ki Hwang,Kevin O. Saunders,Kevin O. Saunders,Ruijun Zhang,Morgan A. Gladden,Anthony Monroe,Amit Kumar,Shi-Mao Xia,Melissa Cooper,Mark K. Louder,Krisha McKee,Robert T. Bailer,Brendan W. Pier,Claudia A. Jette,Garnett Kelsoe,Garnett Kelsoe,Wilton B. Williams,Wilton B. Williams,Lynn Morris,John C. Kappes,Kshitij Wagh,Gift Kamanga,Myron S. Cohen,Peter T. Hraber,David C. Montefiori,David C. Montefiori,Ashley M. Trama,Hua-Xin Liao,Hua-Xin Liao,Thomas B. Kepler,M. Anthony Moody,M. Anthony Moody,Feng Gao,Feng Gao,Samuel J. Danishefsky,John R. Mascola,George M. Shaw,Beatrice H. Hahn,Stephen C. Harrison,Bette T. Korber,Barton F. Haynes,Barton F. Haynes +55 more
TL;DR: By studying the cooperation among multiple V3-glycan B cell lineages and their coevolution with autologous virus throughout 5 years of infection, key events are identified in the ontogeny of a V3 -glycan bnAb lineage.
Journal ArticleDOI
Cell biology meets biophysics to unveil the different mechanisms of penetratin internalization in cells
Isabel D. Alves,Chen-Yu Jiao,Soline Aubry,Baptiste Aussedat,Fabienne Burlina,Gérard Chassaing,Sandrine Sagan +6 more
TL;DR: This review will focus solely on penetratin membrane interactions and internalization mechanisms and suggests that different translocation mechanisms could co-exist, an idea that emerges from recent studies.
Journal ArticleDOI
Toward Fully Synthetic Homogeneous β-Human Follicle-Stimulating Hormone (β-hFSH) with a Biantennary N-Linked Dodecasaccharide. Synthesis of β-hFSH with Chitobiose Units at the Natural Linkage Sites
Pavel Nagorny,Bernhard Fasching,Xuechen Li,Gong Chen,Baptiste Aussedat,Samuel J. Danishefsky,Samuel J. Danishefsky +6 more
TL;DR: A highly convergent synthesis of the sialic acid-rich biantennary N-linked glycan found in human glycoprotein hormones and its use in the synthesis of a fragment derived from the beta-domain of human Follicle-Stimulating Hormone (hFSH) are described.
Journal ArticleDOI
Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.
S. Munir Alam,Baptiste Aussedat,Yusuf Vohra,R. Ryan Meyerhoff,Evan M. Cale,William E. Walkowicz,Nathan Radakovich,Kara Anasti,Lawrence C. Armand,Robert Parks,Laura L. Sutherland,Richard M. Scearce,M. Gordon Joyce,Marie Pancera,Aliaksandr Druz,Ivelin S. Georgiev,Tarra Von Holle,Amanda Eaton,Christopher B. Fox,Steven G. Reed,Mark K. Louder,Robert T. Bailer,Lynn Morris,Salim Abdool-Karim,Myron S. Cohen,Hua-Xin Liao,David C. Montefiori,Peter K. Park,Alberto Fernández-Tejada,Kevin Wiehe,Sampa Santra,Thomas B. Kepler,Kevin O. Saunders,Joseph Sodroski,Peter D. Kwong,John R. Mascola,Mattia Bonsignori,M. Anthony Moody,Samuel J. Danishefsky,Barton F. Haynes +39 more
TL;DR: The Man9-V3 glycopeptide closely mimics an HIV-1 V 3-glycan bnAb epitope and can be used to isolate V3-gly can bnAbs, which could pave the way for a vaccine that protects against diverse strains of HIV.
Journal ArticleDOI
An advance in the chemical synthesis of homogeneous N-linked glycopolypeptides by convergent aspartylation.
TL;DR: A one-flask aspartylation/deprotection method, wherein long peptide fragments, bearing proximal pseudoproline functionality are merged with complex glycan domains, is developed, describing a useful advance in glycopeptide synthesis.