M
Morgan A. Gladden
Researcher at Duke University
Publications - 7
Citations - 714
Morgan A. Gladden is an academic researcher from Duke University. The author has contributed to research in topics: Epitope & Somatic hypermutation. The author has an hindex of 4, co-authored 6 publications receiving 560 citations. Previous affiliations of Morgan A. Gladden include Durham University.
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Journal ArticleDOI
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
Mattia Bonsignori,Tongqing Zhou,Zizhang Sheng,Lei Chen,Feng Gao,M. Gordon Joyce,Gabriel Ozorowski,Gwo-Yu Chuang,Chaim A. Schramm,Kevin Wiehe,S. Munir Alam,Todd Bradley,Morgan A. Gladden,Kwan-Ki Hwang,Sheelah Iyengar,Amit Kumar,Xiaozhi Lu,Kan Luo,Michael C. Mangiapani,Robert Parks,Hongshuo Song,Priyamvada Acharya,Robert T. Bailer,Allen Cao,Aliaksandr Druz,Ivelin S. Georgiev,Young Do Kwon,Mark K. Louder,Baoshan Zhang,Anqi Zheng,Brenna J. Hill,Rui Kong,Cinque Soto,James C. Mullikin,Daniel C. Douek,David C. Montefiori,M. A. Moody,George M. Shaw,Beatrice H. Hahn,Garnett Kelsoe,Peter T. Hraber,Bette T. Korber,Scott D. Boyd,Andrew Fire,Thomas B. Kepler,Lawrence Shapiro,Lawrence Shapiro,Andrew B. Ward,John R. Mascola,Hua-Xin Liao,Peter D. Kwong,Barton F. Haynes +51 more
TL;DR: The development of a VH1-46-derived antibody lineage that matured to neutralize 90% of HIV-1 isolates is defined with longitudinal sampling from time-of-infection to suggest a vaccination strategy for inducing both lineages.
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A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
Neville K. Kisalu,Azza H. Idris,Connor Weidle,Yevel Flores-Garcia,Barbara J. Flynn,Brandon K. Sack,Sean C. Murphy,Arne Schön,Ernesto Freire,Joseph R. Francica,Alex B. Miller,Jason Gregory,Sandra March,Hua-Xin Liao,Barton F. Haynes,Kevin Wiehe,Ashley M. Trama,Kevin O. Saunders,Morgan A. Gladden,Anthony Monroe,Mattia Bonsignori,Masaru Kanekiyo,Adam K. Wheatley,Adrian B. McDermott,S. Katie Farney,Gwo-Yu Chuang,Baoshan Zhang,Natasha Kc,Sumana Chakravarty,Peter D. Kwong,Photini Sinnis,Sangeeta N. Bhatia,Stefan H. I. Kappe,B. Kim Lee Sim,Stephen L. Hoffman,Fidel Zavala,Marie Pancera,Robert A. Seder +37 more
TL;DR: The demonstration that CIS43 is highly effective for passive prevention of malaria has potential application for use in travelers, military personnel and elimination campaigns and identifies a new and conserved site of vulnerability on PfCSP for next-generation rational vaccine design.
Journal ArticleDOI
Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies
Mattia Bonsignori,Mattia Bonsignori,Edward F. Kreider,Daniela Fera,R. Ryan Meyerhoff,R. Ryan Meyerhoff,Todd Bradley,Todd Bradley,Kevin Wiehe,Kevin Wiehe,S. Munir Alam,S. Munir Alam,Baptiste Aussedat,William E. Walkowicz,Kwan-Ki Hwang,Kevin O. Saunders,Kevin O. Saunders,Ruijun Zhang,Morgan A. Gladden,Anthony Monroe,Amit Kumar,Shi-Mao Xia,Melissa Cooper,Mark K. Louder,Krisha McKee,Robert T. Bailer,Brendan W. Pier,Claudia A. Jette,Garnett Kelsoe,Garnett Kelsoe,Wilton B. Williams,Wilton B. Williams,Lynn Morris,John C. Kappes,Kshitij Wagh,Gift Kamanga,Myron S. Cohen,Peter T. Hraber,David C. Montefiori,David C. Montefiori,Ashley M. Trama,Hua-Xin Liao,Hua-Xin Liao,Thomas B. Kepler,M. Anthony Moody,M. Anthony Moody,Feng Gao,Feng Gao,Samuel J. Danishefsky,John R. Mascola,George M. Shaw,Beatrice H. Hahn,Stephen C. Harrison,Bette T. Korber,Barton F. Haynes,Barton F. Haynes +55 more
TL;DR: By studying the cooperation among multiple V3-glycan B cell lineages and their coevolution with autologous virus throughout 5 years of infection, key events are identified in the ontogeny of a V3 -glycan bnAb lineage.
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IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells
Maria Blasi,Donatella R.M. Negri,Donatella R.M. Negri,Celia C. LaBranche,S. Munir Alam,Erich J Baker,Elizabeth C Brunner,Morgan A. Gladden,Zuleika Michelini,Nathan Vandergrift,Kevin Wiehe,Robert Parks,Xiaoying Shen,Mattia Bonsignori,Georgia D. Tomaras,Guido Ferrari,David C. Montefiori,Sampa Santra,Barton F. Haynes,M. A. Moody,Andrea Cara,Andrea Cara,Mary E. Klotman +22 more
TL;DR: It is found that a single IDLV-Env immunization induces continuous antibody avidity maturation and boosting with a heterologous HIV-1 Env results in lower peak antibody titers than autologous boost.
Journal ArticleDOI
A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization
Tulika Singh,Kwan-Ki Hwang,Andrew P. Miller,Rebecca Jones,Cesar A. Lopez,Sarah J. Dulson,Camila Giuberti,Morgan A. Gladden,I. Miller,Helen S. Webster,Joshua Eudailey,Kan Luo,Tarra Von Holle,Robert Edwards,Sarah Valencia,Katherine E. Burgomaster,Summer L. Zhang,Jesse F. Mangold,Joshua J. Tu,Maria Dennis,S. Munir Alam,Lakshmanane Premkumar,Reynaldo Dietze,Theodore C. Pierson,Eng Eong Ooi,Helen M. Lazear,Richard J. Kuhn,Sallie R. Permar,Mattia Bonsignori +28 more
TL;DR: In this article , the authors demonstrate that plasma IgM contributes to ZIKV immunity in pregnancy, mediating neutralization up to 3 months post-symptoms, by targeting an envelope dimer epitope within domain II.