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Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
Papers
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Journal ArticleDOI
Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics
Laura Rué,Tom Jaspers,Isabelle M S Degors,Samuel Noppen,Dominique Schols,Bart De Strooper,Maarten Dewilde +6 more
TL;DR: In this paper , the authors reported the discovery of two nanobodies that were able to bind human and cynomolgus TfR, making them more clinically relevant, and fused with an anti-beta-site amyloid precursor protein cleaving enzyme (BACE1) antibody (1A11AM).
Patent
Therapeutic agents for neurological and psychiatric disorders
TL;DR: In this article, the authors present compounds able to interfere with the association of soluble amyloid precursor protein α (sAPPα) with Sushi domain 1 of GABA B R1a and as such with selective impairment of GABA b R 1a beneficial in neurological and psychiatric disorders.
Posted ContentDOI
The MIR-NAT MAPT-AS1 does not regulate Tau expression in human neurons
Rafaela Hasse e Silva Policarpo,Leen Wolfs,Saúl Martínez-Montero,Lina Vandermeulen,Ines E. Royaux,Gert Van Peer,Pieter Mestdagh,Annerieke Sierksma,Bart De Strooper,Constantin d’Ydewalle +9 more
TL;DR: In this article , the authors investigated the potential functions of MAPT-AS1 in neurons using the same gain-and loss-of-function experiments as described in the original report and expanded their analysis with complementary approaches.