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Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Aducanumab: a new phase in therapeutic development for Alzheimer's disease?
TL;DR: In this article, the FDA approved aducanumab, the first new drug for Alzheimer's disease in almost 20 years and notably the first drug with a putative disease-modifying mechanism for the treatment of this devastating disorder.
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Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation
L. M. Yshii,Emanuela Pasciuto,Pascal Bielefeld,Loriana G. Mascali,Pierre Lemaitre,Maria Michela Marino,James Dooley,Lubna Kouser,Stijn Verschoren,Vasiliki Lagou,Hannelore Kemps,Pascal Gervois,Antina de Boer,Oliver T. Burton,Jérôme Wahis,Jens Verhaert,Samar H. K. Tareen,Carlos P. Roca,Kailash K Singh,Carly E. Whyte,Axelle Kerstens,Zsuzsanna Callaerts-Vegh,Suresh Poovathingal,Teresa Prezzemolo,Keimpe D. Wierda,Amy Dashwood,Junhua Xie,Elien Van Wonterghem,Eline Creemers,Meryem Aloulou,Willy Gsell,Oihane Abiega,Sebastian Munck,Roosmarijn E. Vandenbroucke,Annelies Bronckaers,Robin Lemmens,Bart De Strooper,Ludo Van Den Bosch,Uwe Himmelreich,Carlos P. Fitzsimons,Matthew Holt,Adrian Liston +41 more
TL;DR: In this article , the authors identified brain interleukin 2 (IL-2) levels as a limiting factor for brain-resident Treg cells and developed a gene-delivery approach for astrocytes, with a small-molecule on-switch to allow temporal control.
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Prion protein in Alzheimer's pathogenesis: a hot and controversial issue.
TL;DR: It is shown that the role of prion protein PrPc in Aβ related toxicity is far from ‘black and white’ suggesting complex interpretations of the data available thus far.
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PLD3 gene and processing of APP
Pietro Fazzari,Katrien Horré,Amaia M. Arranz,Carlo Sala Frigerio,Takashi Saito,Takaomi C. Saido,Bart De Strooper,Bart De Strooper +7 more
TL;DR: This research attacked the mode of cell reprograming using a probabilistic approach and found it to be a very simple and straightforward process to correct for multiple sclerosis.
Journal ArticleDOI
Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization
Vasiliki Michaki,Vasiliki Michaki,Francesc X. Guix,Francesc X. Guix,Krist'l Vennekens,Krist'l Vennekens,Sebastian Munck,Sebastian Munck,Colin Dingwall,John B. Davis,Danyelle M. Townsend,Kenneth D. Tew,Fabian Feiguin,Bart De Strooper,Bart De Strooper,Carlos G. Dotti,Carlos G. Dotti,Carlos G. Dotti,Tina Wahle +18 more
TL;DR: Reduced Abca2 levels in mammalian cells in vitro, in Drosophila melanogaster and in mice resulted in altered γ-secretase processing of APP, and thus Aβ generation, without affecting Notch cleavage.