B
Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Journal ArticleDOI
Post-translational modification of the β-subunit of the human fibronectin receptor
Martine Jaspers,Bart De Strooper,Marijke Spaepen,Fred Van Leuven,Guido David,Herman Van den Berghe,Jean-Jacques Cassiman +6 more
TL;DR: Pulse‐chase experiments with [35S]methionine in human skin fibroblasts and endo H digestion and [3H]fucose labeling suggested that maturation converted the high‐mannose oligosaccharides to the endoglycosidase H resistant complex type.
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A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease.
Diego Sepulveda-Falla,Diego Sepulveda-Falla,Lucía Chávez-Gutiérrez,Erik Portelius,Erik Portelius,Jorge I. Vélez,Jorge I. Vélez,Simon Dujardin,Alvaro Barrera-Ocampo,Alvaro Barrera-Ocampo,Felix Dinkel,Christian Hagel,Berta Puig,Claudio A. Mastronardi,Claudio A. Mastronardi,Francisco Lopera,Bradley T. Hyman,Kaj Blennow,Kaj Blennow,Mauricio Arcos-Burgos,Bart De Strooper,Bart De Strooper,Markus Glatzel +22 more
TL;DR: Tau hyperphosphorylation pattern, and its degradation by the proteasome, drastically influences disease onset in individuals with otherwise similar Aβ pathology, hinting toward a multifactorial model of disease for FAD.
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Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
Jonathan D.J. Wrigley,Emma J. Nunn,Omar Nyabi,Earl E. Clarke,Peter W. Hunt,Alan Nadin,Bart De Strooper,Mark S. Shearman,Dirk Beher +8 more
TL;DR: It is reported that replacement of either tyrosine residue alters γ‐secretase cleavage specificity, resulting in an increase in the production of the more pathogenic Aβ(42) peptide in both cells and membranous enzyme preparations, without affecting inhibitor binding.
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Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder.
TL;DR: The progressive CNS disorder elicited in the transgenic APP/RK mice recapitulates certain features and symptoms of patients with Alzheimer's disease as discussed.
Journal ArticleDOI
Defining Microglial States and Nomenclature: A Roadmap to 2030
Rosa C. Paolicelli,Amanda Sierra,Beth Stevens,Marie-Ève Tremblay,Adriano Aguzzi,Bahareh Ajami,Ido Amit,Etienne Audinat,Ingo Bechmann,Mariko L. Bennett,Frederick Joseph Bennett,Alain Bessis,Knut Biber,Staci D. Bilbo,Mathew Blurton-Jones,Erik Boddeke,Dora Brites,Bert Brône,Guy C. Brown,Oleg Butovsky,Monica J. Carson,Bernardo Castellano,Marco Colonna,Sally A. Cowley,Colm Cunningham,Dimitrios Davalos,Philip L. De Jager,Bart De Strooper,Adam Denes,Bart J. L. Eggen,Ukpong B. Eyo,Elena Galea,Sonia Garel,Florent Ginhoux,Christopher K. Glass,Ozgun Gokce,Diego Gomez-Nicola,Berta González,Siamon Gordon,Manuel B. Graeber,Andrew D. Greenhalgh,Pierre Gressens,Melanie Greter,David H. Gutmann,Christian Haass,Michael T. Heneka,Frank L. Heppner,Soyon Youngae Hong,Helmut Kettenmann,Jonathan Kipnis,Ryuta Koyama,Greg Lemke,Marina A. Lynch,Ania K. Majewska,Marzia Malcangio,Tarja Malm,Renzo Mancuso,Michela Matteoli,Barry W. McColl,Veronique E. Miron,Anna V. Molofsky,Michelle Monje,Eva Mracsko,Agnès Nadjar,Jonas J. Neher,Urte Neniskyte,Harald Neumann,Mami Noda,Bo Peng,Francesca Peri,V. Hugh Perry,Phillip G. Popovich,Josef Priller,Davide Ragozzino,Richard M. Ransohoff,Michael W. Salter,Anne Schaefer,Dorothy A. Schafer,Michal Schwartz,Mikael Simons,Wolfgang J. Streit,Tuan Leng Tay,Li-Huei Tsai,Alexei Verkhratsky,Rommy von Bernhardi,Hiroaki Wake,Valérie Wittamer,Susanne A. Wolf,Longyan Wu,Tony Wyss-Coray +89 more