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Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Journal ArticleDOI
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
Vanessa A. Morais,Patrik Verstreken,Anne Roethig,Joél Smet,An Snellinx,Mieke Vanbrabant,Dominik Haddad,Christian Frezza,Wilhelm Mandemakers,Daniela Vogt-Weisenhorn,Rudy Van Coster,Wolfgang Wurst,Luca Scorrano,Bart De Strooper +13 more
TL;DR: It is shown that PINK1 deficiency or clinical mutations impact on the function of Complex I of the mitochondrial respiratory chain, resulting in mitochondrial depolarization and increased sensitivity to apoptotic stress in mammalian cells and tissues.
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Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease.
TL;DR: In this paper, the authors evaluate the implications of this model for the amyloid-cascade hypothesis and for the efficacy of presenilin/γ-secretase as a drug target.
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Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice
Diana Ines Dominguez,Jos Tournoy,Dieter Hartmann,Tobias Huth,Kim Cryns,Siska Deforce,Lutgarde Serneels,Ira Mercedes Espuny Camacho,Els Marjaux,Katleen Craessaerts,Anton J.M. Roebroek,Michael Schwake,Rudi D'Hooge,Patricia Bach,Ulrich Kalinke,Dieder Moechars,Christian Alzheimer,Karina Reiss,Paul Saftig,Bart De Strooper +19 more
TL;DR: The data indicate that BACE2 could indeed contribute to Aβ generation in the brains of Alzheimer disease and, in particular, Down syndrome patients and call for some caution when claiming that no major side effects should be expected from blocking BACE1 activity.
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Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.
Sebastiaan De Schepper,Simon Verheijden,Javier Aguilera-Lizarraga,Maria Francesca Viola,Werend Boesmans,Nathalie Stakenborg,Iryna Voytyuk,Inga Schmidt,Bram Boeckx,Isabelle Dierckx de Casterlé,Veerle Baekelandt,Erika Gonzalez Dominguez,Matthias Mack,Inge Depoortere,Bart De Strooper,Bart De Strooper,Ben Sprangers,Uwe Himmelreich,Stefaan J. Soenen,Martin Guilliams,Pieter Vanden Berghe,Elizabeth A. V. Jones,Diether Lambrechts,Guy E. Boeckxstaens +23 more
TL;DR: A self-maintaining population of macrophages that arise from both embryonic precursors and adult bone marrow-derived monocytes and persists throughout adulthood is identified and its strategic role in gut homeostasis and intestinal physiology is demonstrated.
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The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex
Ellen Jorissen,Johannes Prox,Christian Bernreuther,Silvio Weber,Ralf Schwanbeck,Lutgarde Serneels,An Snellinx,Kathleen Craessaerts,Amantha Thathiah,Ina Tesseur,Udo Bartsch,Gisela Weskamp,Carl P. Blobel,Markus Glatzel,Bart De Strooper,Paul Saftig +15 more
TL;DR: This study reveals that ADAM10 plays a central role in the developing brain by controlling mainly Notch-dependent pathways but likely also by reducing surface shedding of other neuronal membrane proteins including APP.