B
Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Secretases as therapeutic targets for the treatment of Alzheimer's disease
TL;DR: The mailable data are conclusive and crown BACE as the long-sought β-secretuse, a prime candidate drug target for the development of therapy aiming to lower the amyloid burden in the disease and paving the road towards selective inhibitors of this secretase.
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Molecular Plasticity Regulates Oligomerization and Cytotoxicity of the Multipeptide-length Amyloid-β Peptide Pool
Annelies Vandersteen,Marcelo F. Masman,Greet De Baets,Greet De Baets,Wim Jonckheere,Kees van der Werf,Siewert J. Marrink,Jef Rozenski,Iryna Benilova,Bart De Strooper,Vinod Subramaniam,Joost Schymkowitz,Joost Schymkowitz,Frederic Rousseau,Frederic Rousseau,Kerensa Broersen,Kerensa Broersen +16 more
TL;DR: The results indicate that the complex in vivo Aβ peptide array and variations thereof is critical in Alzheimer disease, which can influence the selection of current and new therapeutic strategies.
Journal Article
A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes
D. B. T. Govinda Raj,Bart Ghesquière,Arun Kumar Tharkeshwar,Katrijn Coen,Rita Derua,Dieter Vanderschaeghe,Evelien Rysman,Murali Bagadi,Pieter Baatsen,Bart De Strooper,Etienne Waelkens,Gustaaf Borghs,Nico Callewaert,Johan F.M. Swinnen,Katrien Gevaert,Wim Annaert +15 more
TL;DR: A novel type of lipid‐coated superparamagnetic nanoparticles are manufactured that allow for a rapid isolation of plasma membranes (PMs), enabling high‐resolution proteomic, glycomic and lipidomic analyses of the cell surface, finding that many proteins are selectively downregulated at thecell surface of presenilin knockout cells.
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The primary sequence and the subunit structure of mouse alpha-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA.
Fred Van Leuven,Sophie Torrekens,Lut Overbergh,K. Lorent,Bart De Strooper,Herman Van den Berghe +5 more
TL;DR: Analysis of the predicted protein showed all the salient features of a proteinase inhibitor of the macroglobulin family: a bait region that deviates from all known sequences in this family, a very conserved internal thiolester site and conserved cysteine residues and putative N-glycosylation sites.
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Neurons Generated from APP/APLP1/APLP2 Triple Knockout Embryonic Stem Cells Behave Normally in Vitro and in Vivo: Lack of Evidence for a Cell Autonomous Role of the Amyloid Precursor Protein in Neuronal Differentiation
Bruno Bergmans,Bruno Bergmans,S. Ali M. Shariati,S. Ali M. Shariati,Ron L. P. Habets,Ron L. P. Habets,Patrik Verstreken,Patrik Verstreken,Luc Schoonjans,Ulrike Müller,Carlos G. Dotti,Carlos G. Dotti,Bart De Strooper,Bart De Strooper +13 more
TL;DR: The results suggest that the loss of the APP family of proteins has no major effect on these critical neuronal processes and that the apparent multitude of functions in which APP has been implicated might be characterized by molecular redundancy.