B
Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Comparison and meta-analysis of microarray data: from the bench to the computer desk.
TL;DR: This review focuses on the problems associated with the efficient access to and exchange of microarray data; the validation and comparison of data from different platforms (cDNA and short and long oligonucleotides); and the integrated statistical analysis of multiple data sets.
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Pathogenic APP mutations near the γ-secretase cleavage site differentially affect Aβ secretion and APP C-terminal fragment stability
Chris De Jonghe,Cary Esselens,Samir Kumar-Singh,Katleen Craessaerts,Sally Serneels,Frédéric Checler,Wim Annaert,Christine Van Broeckhoven,Bart De Strooper +8 more
TL;DR: Taking advantage of an extended series of APP mutations, an inverse correlation between these ratios and the age at onset of the disease in the different families is demonstrated and a subset of mutations caused the accumulation of APP C-terminal fragments indicating that these mutations also influence the stability ofAPP C- terminal fragments.
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Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
Ira Espuny-Camacho,Amaia M. Arranz,Mark Fiers,An Snellinx,Kunie Ando,Sebastian Munck,Jérôme Bonnefont,Laurie Lambot,Nikky Corthout,Lorna Omodho,Elke Vanden Eynden,Enrico Radaelli,Ina Tesseur,Selina Wray,Andreas Ebneth,John Hardy,Karelle Leroy,Jean Pierre Brion,Pierre Vanderhaeghen,Pierre Vanderhaeghen,Bart De Strooper,Bart De Strooper +21 more
TL;DR: This novel chimeric model for AD displays human-specific pathological features and allows the analysis of different genetic backgrounds and mutations during the course of the disease.
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Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase.
Peer-Hendrik Kuhn,Els Marjaux,Axel Imhof,Bart De Strooper,Christian Haass,Stefan F. Lichtenthaler +5 more
TL;DR: A similar proteolytic processing of IL-1R2 and APP is revealed and may provide an explanation for the increased IL- 1R2 secretion observed in AD.
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A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases.
TL;DR: The emerging evidence clearly demonstrates the crucial role of specific mitochondrial functions in maintaining neuronal circuit integrity and indicates that mitochondrial dynamics are especially important for the long-term maintenance of the nervous system.