B
Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Journal ArticleDOI
Alzheimer's disease. Closing in on gamma-secretase
TL;DR: For decades, a short amyloid peptide called Aβ has been thought to underlie the neurodegeneration characteristic of Alzheimer's disease as discussed by the authors, but this peptide is produced from a longer precursor protein by two protein-cleaving enzymes, known as βsecretase and γ-secretase.
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Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription.
Elaine Waldron,Simone Isbert,Andreas Kern,Sebastian Jaeger,Anne M. Martin,Sébastien S. Hébert,Christian Behl,Sascha Weggen,Bart De Strooper,Claus U. Pietrzik +9 more
TL;DR: There is strong evidence that an increase in AICD generation does not directly promote gene activation of previously proposed target genes, as shown by the unchanged levels of target gene mRNA.
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Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice.
Aikaterini S. Papadopoulou,Lutgarde Serneels,Tilmann Achsel,Wim Mandemakers,Zsuzsanna Callaerts-Vegh,James Dooley,Pierre Lau,Torik A.Y. Ayoubi,Enrico Radaelli,Marco Spinazzi,Melanie Neumann,Sébastien S. Hébert,Asli Silahtaroglu,Adrian Liston,Rudi D'Hooge,Markus Glatzel,Bart De Strooper,Bart De Strooper +17 more
TL;DR: Morphological analysis showed that Purkinje cells are smaller and display less dendritic arborisation compared to their wildtype littermates and several mRNAs significantly up-regulated in the absence of the miR-29a/b-1 cluster.
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Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice.
Ina Tesseur,Anna A. Pimenova,Adrian C. Lo,Marta Ciesielska,Stefan F. Lichtenthaler,Joris H. De Maeyer,Jan A.J. Schuurkes,Rudi D'Hooge,Bart De Strooper +8 more
TL;DR: A novel high-affinity 5-HT4 receptor agonist SSP-002392 is described that, in cultured human neuroblastoma cells, potently increases the levels of cAMP and sAPPα at 100-fold lower concentrations than the effective concentrations of prucalopride, a known selective 5- HT4 receptors agonist.
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In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity.
Samir Kumar-Singh,Ann Julliams,Rony Nuydens,Chantal Ceuterick,Christine Labeur,Sally Serneels,Krist'l Vennekens,Peter Van Osta,Hugo Geerts,Bart De Strooper,Christine Van Broeckhoven +10 more
TL;DR: It is proposed here that, at least in vitro, Abeta might be neurotoxic in an initial phase due to its soluble oligomeric or other early toxic Abeta intermediate(s), which is perhaps distinct from the late neurotoxicity incurred by aggregated larger assemblies of Abeta.