B
Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
Papers
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The amyloid-β precursor protein: integrating structure with biological function
TL;DR: The different subdomains of APP are studied in detail and functional significance is assigned to particular structures identified in the protein.
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The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture.
TL;DR: It is demonstrated here that APP‐C59 is rapidly degraded when overexpressed in baby hamster kidney cells or primary cultures of neurones by a mechanism that is not inhibited by endosomal/lysosomal or proteasome inhibitors, and it is suggested that the APP intracellular domain could have a role in signalling events from the plasma membrane to the nucleus.
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Lessons from a Failed γ-Secretase Alzheimer Trial
TL;DR: Analysis of available information presented here demonstrates significant confounds for interpreting the outcome of the trial and argues that the major lessons pertain to broad knowledge gaps that are imperative to fill.
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Presenilin couples the paired phosphorylation of β-catenin independent of axin: Implications for β-catenin activation in tumorigenesis
David E. Kang,Salvador Soriano,Xuefeng Xia,Charles G. Eberhart,Bart De Strooper,Hui Zheng,Edward H. Koo +6 more
TL;DR: It is shown that presenilin functions as a scaffold that rapidly couples beta-catenin phosphorylation through two sequential kinase activities independent of the Wnt-regulated Axin/CK1alpha complex, and results in increased beta-Catenin stability in vitro and in vivo.
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Non-coding RNAs with essential roles in neurodegenerative disorders
Evgenia Salta,Bart De Strooper +1 more
TL;DR: Advances in understanding of the function of ncRNAs in the CNS are discussed, with a focus on the potential involvement of specific species, such as microRNAs, endogenous small interfering RNAs, long intergenic non-coding RNas, and natural antisense transcripts, in various neurodegenerative disorders.