B
Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Journal ArticleDOI
BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants.
Maarten Timmers,Maarten Timmers,Soraia Barão Lourenco Barao,Bianca Van Broeck,Ina Tesseur,John Slemmon,Katja De Waepenaert,Jennifer Bogert,Leslie M. Shaw,Sebastiaan Engelborghs,Dieder Moechars,Marc Mercken,Luc Van Nueten,Luc Tritsmans,Bart De Strooper,Bart De Strooper,Johannes Streffer,Johannes Streffer +17 more
TL;DR: This is the first reported finding that shows BACE1 levels in CSF were well correlated to its end product Aβ1 - 42, and follow-up studies including early-stage AD pathophysiology and prodromal AD patients will help to understand the importance of measuring Bace1 routinely in daily clinical practice and AD clinical trials.
Journal ArticleDOI
Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells.
TL;DR: The default secretory pathway of COS cells and the basolateral (but not the apical) secretory pathways of MDCK cells are comparably sensitive to methylamine and not to bafilomycin, but both drugs strongly increased apical secretion.
Journal ArticleDOI
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation
Pablo Largo-Barrientos,Pablo Largo-Barrientos,Nuno Apóstolo,Nuno Apóstolo,Eline Creemers,Eline Creemers,Zsuzsanna Callaerts-Vegh,Jef Swerts,Jef Swerts,Caitlin Davies,Joseph McInnes,Joseph McInnes,Keimpe D. Wierda,Keimpe D. Wierda,Bart De Strooper,Bart De Strooper,Bart De Strooper,Tara L. Spires-Jones,Joris de Wit,Joris de Wit,Valerie Uytterhoeven,Valerie Uytterhoeven,Patrik Verstreken,Patrik Verstreken +23 more
TL;DR: In this paper, the role of pathogenic Tau at pre-synaptic terminals was determined by interfering with the function of synaptogyrin-3 on synaptic vesicles.
Journal ArticleDOI
BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid.
Soraia Barão Lourenco Barao,Lujia Zhou,Katarzyna Adamczuk,Tine Vanhoutvin,Fred Van Leuven,David Demedts,Anne-Catherine Vijverman,Xavier Bossuyt,Rik Vandenberghe,Bart De Strooper +9 more
TL;DR: BACE1 levels in CSF of AD patients and other neurological disorder patients are slightly increased when compared to those of a non-neurological disorder control group (NND), suggesting that the recorded alterations in Bace1 levels correlate with cell death and neurodegeneration.
Journal ArticleDOI
Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling
Pietro Fazzari,An Snellinx,Victor Sabanov,Tariq Ahmed,Lutgarde Serneels,Annette Gärtner,S. Ali M. Shariati,Detlef Balschun,Bart De Strooper +8 more
TL;DR: Light is shed on the physiological role of Aph1b-γ-secretase in brain and a new mechanistic perspective on the relevance of NRG1 processing in schizophrenia is provided.