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Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Journal ArticleDOI
Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons
Andreea-Alexandra Ungureanu,Iryna Benilova,Olga Krylychkina,Dries Braeken,Bart De Strooper,Chris Van Haesendonck,Carlos G. Dotti,Carlos G. Dotti,Carmen Bartic +8 more
TL;DR: Using quantitative atomic force microscopy (AFM), the static elastic modulus of living primary hippocampal neurons treated with pre-aggregated Aβ40 and Aβ42 soluble species is measured for the first time.
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Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration
Juan Antonio García-León,Alfredo Cabrera-Socorro,Kristel Eggermont,Ann Swijsen,Joke Terryn,Raheem Fazal,Fatemeharefeh Nami,Laura Ordovás,Ana Quiles,Frederic Lluis,Lutgarde Serneels,Keimpe D. Wierda,Annerieke Sierksma,Mohamed Kreir,Francisco Pestana,Philip Van Damme,Bart De Strooper,Bart De Strooper,Lieven Thorrez,Andreas Ebneth,Catherine M. Verfaillie +20 more
TL;DR: In this article, a footprint-free triple MAPT -mutant human induced pluripotent stem cell line (N279K, P301L, and E10+16 mutations) was generated using clustered regularly interspaced short palindromic repeats-FokI and piggyBac transposase technology.
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BACE2 distribution in major brain cell types and identification of novel substrates.
Iryna Voytyuk,Iryna Voytyuk,Stephan Mueller,Stephan Mueller,Julia Herber,Julia Herber,An Snellinx,An Snellinx,Dieder Moechars,Geert van Loo,Stefan F. Lichtenthaler,Bart De Strooper +11 more
TL;DR: It is shown that BACE2 is expressed in discrete subsets of neurons and glia throughout the adult mouse brain and identified its substrates, and it is important to consider that side effects might become apparent under physiopathological conditions that induce TNF expression.
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Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.
Tomas Borgegard,Susanne Gustavsson,Charlotte B. Nilsson,Santiago Parpal,Rebecka Klintenberg,Anna-Lena Berg,Susanne Rosqvist,Lutgarde Serneels,Samuel P.S. Svensson,Samuel P.S. Svensson,Fredrik Olsson,Shaobo Jin,Hongmei Yan,Johanna Wanngren,Anders Juréus,Anna Ridderstad-Wollberg,Patrik Wollberg,Kenneth Stockling,Helena Karlström,Åsa Malmberg,Johan Lund,Per I. Arvidsson,Per I. Arvidsson,Per I. Arvidsson,Bart De Strooper,Urban Lendahl,Johan Lundkvist,Johan Lundkvist +27 more
TL;DR: It is shown that PS2 plays an important role in mediating essential Notch signaling in several peripheral organs during pharmacological inhibition of PS1 and provides preclinical in vivo proof of concept for PS2-sparing inhibition as a novel, tolerable and efficacious γ-secretase targeting strategy for AD.
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Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP NL-F/NL-F knock-in mice
Disha Shah,Disha Shah,Amira Latif-Hernandez,Bart De Strooper,Takashi Saito,Takaomi C. Saido,Marleen Verhoye,Rudi D'Hooge,Annemie Van der Linden +8 more
TL;DR: The occurrence of these defects in APPNL-F/NL-F mice demonstrates that cognitive flexibility and synchronicity of telencephalic activity are specifically altered by early Aβ pathology without changes in APP neurochemistry.