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Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Journal ArticleDOI
The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
Philippe Cupers,Mustapha Bentahir,Katleen Craessaerts,Isabelle Orlans,Hugo Vanderstichele,Paul Saftig,Bart De Strooper,Wim Annaert +7 more
TL;DR: It is concluded that γ-secretase cleavage of APP-C99 occurs in a specialized subcellular compartment where little or no PS1 is detected, which suggests that at least one other factor than PS1, located downstream of the ER, is required for theγ-cleavage ofAPP-C 99.
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Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid-β1–42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model
Jonathan Brouillette,Raphaëlle Caillierez,Nadège Zommer,Claire Alves-Pires,Iryna Benilova,David Blum,Bart De Strooper,Luc Buée +7 more
TL;DR: A novel mouse model provides evidence that small, soluble Aβ1–42 oligomers are able to induce extensive neuronal loss in vivo and initiate a cascade of events that mimic the key neuropathological hallmarks of AD.
Journal ArticleDOI
Role of Presenilins in Neuronal Calcium Homeostasis
TL;DR: Interestingly, it is discovered that presenilins play a major role in ER Ca2+ leak function in hippocampal but not in striatal neurons, and disruption of ER Ca1-mediated leak function of presenILins may play an important role in AD pathogenesis.
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The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Protease in Vivo
Lujia Zhou,Soraia Barão Lourenco Barao,Mathias Laga,Katrijn Bockstael,M. Borgers,Harry Gijsen,Wim Annaert,Diederik Moechars,Marc Mercken,Kris Gevaer,Bart De Strooper +10 more
TL;DR: It is shown that L1 and CHL1 are cleaved by BACE1 under physiological conditions, and this work will help to predict or interpret possible side effects of Bace1 inhibitor drugs in current clinical trials.
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The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor
Aikaterini S. Papadopoulou,James Dooley,Michelle A. Linterman,Wim Pierson,Olga Ucar,Bruno Kyewski,Saulius Zuklys,Georg A. Holländer,Patrick Matthys,Daniel H.D. Gray,Bart De Strooper,Adrian Liston +11 more
TL;DR: It is found that the microRNA network dependent on the endoribonuclease Dicer, and specifically microRNA miR-29a, was critical for diminishing the sensitivity of the thymic epithelium to simulated infection signals, protecting the thcyus against inappropriate involution.