B
Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Journal ArticleDOI
Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease
TL;DR: Although γ-secretase is a top target for developing disease-modifying AD therapeutics, interference with Notch signaling should be avoided, and compounds that alter Aβ production byγ- secretase without affecting Notch proteolysis and signaling have been identified.
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Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin.
Marcus O. W. Grimm,Heike S. Grimm,Andreas J Pätzold,Eva G. Zinser,Riikka Halonen,Marco Duering,Jakob A. Tschäpe,Bart De Strooper,Ulrike Müller,Jie Shen,Tobias Hartmann +10 more
TL;DR: It is shown that control of cholesterol and SM metabolism involves APP processing and also a functional basis for the link that has been observed between lipids and Alzheimer's disease (AD).
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Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
Tracy O'Connor,Katherine R. Sadleir,Erika Maus,Rodney A. Velliquette,Jie Zhao,Sarah L. Cole,William A. Eimer,Brian Hitt,Leslie A. Bembinster,Sven Lammich,Stefan F. Lichtenthaler,Sébastien S. Hébert,Bart De Strooper,Christian Haass,David A. Bennett,Robert Vassar +15 more
TL;DR: It is strongly suggested that eIF2alpha phosphorylation increases BACE1 levels and causes Abeta overproduction, which could be an early, initiating molecular mechanism in sporadic AD.
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Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
TL;DR: The complicated proteolytic pathways that are responsible for the generation and clearance of these fragments, and how disturbances in these pathways interact are discussed to provide a background for a novel understanding of Alzheimer disease as a multifactorial disorder.
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MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
Sébastien S. Hébert,Katrien Horré,Laura Nicolaï,Bruno Bergmans,Aikaterini S. Papadopoulou,André Delacourte,Bart De Strooper +6 more
TL;DR: It is shown that miRNAs belonging to the miR-20a family could regulate APP expression in vitro and at the endogenous level in neuronal cell lines, suggesting that variations in miRNA expression could contribute to changes inAPP expression in the brain during development and disease.