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Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Journal ArticleDOI
γ-secretase inhibitors: Still in the running as Alzheimer's therapeutics
Els Marjaux,Bart De Strooper +1 more
TL;DR: It is argued that this enigmatic protease, a complex of at least four proteins that is responsible for the cleavage of a series of integral membrane proteins, including the amyloid peptide precursor protein and Notch, still has a lot of potential.
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Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease
Joshua Stevenson-Hoare,Amanda Heslegrave,Ganna Leonenko,Dina Fathalla,Eftychia Bellou,L. Luckcuck,Rachel Marshall,Rebecca Sims,B. Paul Morgan,John Hardy,Bart De Strooper,Julie Williams,Henrik Zetterberg,Valentina Escott-Price +13 more
TL;DR: Disease prediction modelling by the combination of all biomarkers indicates that the variance attributed to P-tau181 is mostly captured by APOE-ε4, whereas Aβ40, Aβ42, GFAP and NfL biomarkers explain additional variation over and above APOE.
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No endogenous A beta production in presenilin-deficient fibroblasts.
Omar Nyabi,Stefan Pype,Marc Mercken,An Herreman,Paul Saftig,Kathleen Craessaerts,Lutgarde Serneels,Wim Annaert,Bart De Strooper +8 more
TL;DR: The affinity of the WO-2 antibody is too low to detect mouse Aβ from cells that overexpress mouse APP in this assay, demonstrating unequivocally that the Aβ detected in the experiments of Armogida et al. cannot be of mouse origin.
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Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia.
Diana P. Benitez,Shenyi Jiang,Shenyi Jiang,Jack Wood,Rui Wang,Rui Wang,Chloe M. Hall,Chloe M. Hall,Carlijn Peerboom,Carlijn Peerboom,Natalie Wong,Katie M. Stringer,Katie M. Stringer,Karina S. Vitanova,Victoria C. Smith,Dhaval D. Joshi,Dhaval D. Joshi,Takashi Saito,Takaomi C. Saido,John G. Hardy,Jörg Hanrieder,Jörg Hanrieder,Bart De Strooper,Bart De Strooper,Bart De Strooper,Dervis A. Salih,Takshashila Tripathi,Frances A. Edwards,Damian M. Cummings +28 more
TL;DR: The role of microglia in amyloid plaques and synaptic changes in Alzheimer's disease was investigated in this article, where the authors found that microglial ablation led to aged but not young wild type animals mimicking the increased glutamate release probability in App knock-ins and exacerbated the App Knock-in phenotype.
Journal ArticleDOI
Alzheimer's disease: A protective mutation.
Bart De Strooper,Thierry Voet +1 more
TL;DR: A rare gene variant has been found that decreases the peptide deposition seen in the brains of people with Alzheimer's disease, providing support for the hypothesis that reducing the beta-cleavage of APP may protect against Alzheimer's.