B
Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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Journal ArticleDOI
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.
Sébastien S. Hébert,Lutgarde Serneels,Tim Dejaegere,Katrien Horré,Michal Dabrowski,Veerle Baert,Wim Annaert,Dieter Hartmann,Bart De Strooper +8 more
TL;DR: It is suggested that gamma-secretase is a heterogeneous family of protein complexes widely expressed in the adult organism and several independent gamma- secretase complexes can coexist in the same cell type.
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Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Emanuela Pasciuto,Oliver T. Burton,Carlos P. Roca,Vasiliki Lagou,Wenson D. Rajan,Tom Theys,Renzo Mancuso,Raul Y. Tito,Lubna Kouser,Zsuzsanna Callaerts-Vegh,Alerie Guzman de la Fuente,Teresa Prezzemolo,Loriana G. Mascali,Aleksandra Brajic,Carly E. Whyte,Lidia Yshii,Anna Martínez-Muriana,Michelle Naughton,Andrew Young,Alena Moudra,Pierre Lemaitre,Suresh Poovathingal,Jeroen Raes,Bart De Strooper,Bart De Strooper,Denise C. Fitzgerald,James Dooley,Adrian Liston,Adrian Liston +28 more
TL;DR: A role for CD4 T cells in brain development and a potential interconnected dynamic between the evolution of the immunological and neurological systems are illuminated.
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Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans.
Nicola Thrupp,Nicola Thrupp,Carlo Sala Frigerio,Carlo Sala Frigerio,Carlo Sala Frigerio,Leen Wolfs,Leen Wolfs,Nathan G. Skene,Nicola Fattorelli,Nicola Fattorelli,Suresh Poovathingal,Suresh Poovathingal,Yannick Fourne,Yannick Fourne,Paul M. Matthews,Tom Theys,Renzo Mancuso,Renzo Mancuso,Bart De Strooper,Bart De Strooper,Bart De Strooper,Mark Fiers,Mark Fiers,Mark Fiers +23 more
TL;DR: It is concluded that snRNA-seq is not suited for detecting cellular activation in microglia in human disease.
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Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series
Natalie S. Ryan,Jennifer M. Nicholas,Jennifer M. Nicholas,Philip S.J. Weston,Yuying Liang,Tammaryn Lashley,Rita Guerreiro,Rita Guerreiro,Gary Adamson,Janna Kenny,Jon Beck,Lucía Chávez-Gutiérrez,Bart De Strooper,Bart De Strooper,Tamas Revesz,Janice L. Holton,Simon Mead,Martin N. Rossor,Nick C. Fox +18 more
TL;DR: The importance of considering genetic testing in young patients with dementia and additional neurological features in order to appropriately diagnose and treat their symptoms is highlighted, and of examining different mutation types separately in future research is highlighted.
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The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
Eric Karran,Bart De Strooper +1 more
TL;DR: In this article , the temporal interplay between the two pathognomonic protein aggregates in AD and their relationship to cognitive impairment was investigated. And the authors concluded that the speed of amyloid removal from the brain by a potential therapy will be important in demonstrating clinical benefit in the context of clinical trial.