B
Bart De Strooper
Researcher at Katholieke Universiteit Leuven
Publications - 433
Citations - 56592
Bart De Strooper is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 117, co-authored 397 publications receiving 48516 citations. Previous affiliations of Bart De Strooper include Ghent University & Allen Institute for Brain Science.
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miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain
TL;DR: It is shown that miR‐132 loss exacerbates both amyloid and TAU pathology via inositol 1,4,5‐trisphosphate 3‐kinase B (ITPKB) upregulation in an AD mouse model, indicating the pathological relevance of this pathway in AD.
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LifeTime and improving European healthcare through cell-based interceptive medicine
Nikolaus Rajewsky,Geneviève Almouzni,Stanislaw A. Gorski,Stein Aerts,Ido Amit,Michela G. Bertero,Christoph Bock,Christoph Bock,Annelien L. Bredenoord,Giacomo Cavalli,Susanna Chiocca,Hans Clevers,Bart De Strooper,Bart De Strooper,Angelika Eggert,Jan Ellenberg,Xosé M. Fernández,Marek Figlerowicz,Marek Figlerowicz,Susan M. Gasser,Susan M. Gasser,Norbert Hubner,Jørgen Kjems,Jürgen A. Knoblich,Jürgen A. Knoblich,Grietje Krabbe,Peter Lichter,Sten Linnarsson,Sten Linnarsson,Jean-Christophe Marine,John C. Marioni,John C. Marioni,John C. Marioni,Marc A. Marti-Renom,Mihai G. Netea,Mihai G. Netea,Dörthe Nickel,Marcelo Nollmann,Halina R. Novak,Helen Parkinson,Stefano Piccolo,Inês Pinheiro,Ana Pombo,Ana Pombo,Christian Popp,Wolf Reik,Wolf Reik,Wolf Reik,Sergio Roman-Roman,Philip Rosenstiel,Joachim L. Schultze,Joachim L. Schultze,Oliver Stegle,Amos Tanay,Giuseppe Testa,Giuseppe Testa,Dimitris Thanos,Fabian J. Theis,Maria-Elena Torres-Padilla,Alfonso Valencia,Céline Vallot,Céline Vallot,Alexander van Oudenaarden,Alexander van Oudenaarden,Marie Vidal,Thierry Voet,Thierry Voet +66 more
TL;DR: The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe over the next decade.
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Amyloidogenic Processing of Human Amyloid Precursor Protein in Hippocampal Neurons Devoid of Cathepsin D
Paul Saftig,Christoph Peters,Kurt von Figura,Katleen Craessaerts,Fred Van Leuven,Bart De Strooper +5 more
TL;DR: The results rule out cathepsin D as a critical component of α-, β-, or γ-secretase and therefore as a primary target for drugs aimed at decreasing the βA4-amyloid peptide burden in Alzheimer's disease.
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DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration
Veerle Baekelandt,Anje Claeys,Peter Cherepanov,Erik De Clercq,Bart De Strooper,Bart Nuttin,Zeger Debyser +6 more
TL;DR: The data suggest a protective role of DNA-PK against cellular toxicity induced by high levels of retrovirus integrase or integration, and suggest poly(ADP-ribose) polymerase (PARP) are not essential for lentivirus integration.
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Dysregulated microRNAs in neurodegenerative disorders.
Pierre Lau,Bart De Strooper +1 more
TL;DR: It is proposed that studying microRNAs and their mRNA targets in the context of neurodegeneration will significantly contribute to the identification of proteins important for neuronal function and might reveal underlying molecular networks that drive these diseases.