Bart De Strooper

TL;DR: Using high resolution quantitative mass spectrometry, in-depth proteome maps of human and mouse ex vivo and in vitro microglia are generated and it is revealed a tenfold difference in protein content of ex vivoand in vitro cells and fundamental differences in protein expression related to protein synthesis, metabolism,microglia markers and environmental sensors.

TL;DR: A gene transfer strategy based on adeno-associated virus (AAV)-based vectors to deliver VHH directly into the central nervous system, ensuring continuous production at therapeutic levels is proposed, which is applicable to a range of CNS disease targets.

TL;DR: Investigation of 127,000 single cell expression profiles of human microglia isolated freshly from a xenotransplantation model for early AD finds specific polygenic risk genes are enriched in each branch of these multi-pronged response of humanmicroglia to amyloid pathology (ARM).

TL;DR: These findings provide mechanistic insight into the hitherto elusive functional significance of AHN in AD and designate miR-132 replacement as a novel therapeutic strategy to rejuvenate the AD brain and thereby alleviate aspects of memory decline.

TL;DR: The EMBO Molecular Medicine aims to divulge this knowledge and promote a faster pace for its translation into the clinics as discussed by the authors, which is the goal of the EMBO Conference on Molecular Medicine.