B
Bastian Keck
Researcher at University of Erlangen-Nuremberg
Publications - 84
Citations - 2816
Bastian Keck is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Bladder cancer & Cystectomy. The author has an hindex of 24, co-authored 84 publications receiving 2249 citations. Previous affiliations of Bastian Keck include University of Southern California.
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Journal ArticleDOI
Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma
Jakob Hedegaard,Philippe Lamy,Iver Nordentoft,Ferran Algaba,Søren Høyer,Benedicte Parm Ulhøi,Søren Vang,Thomas Reinert,Gregers G. Hermann,Karin Mogensen,Mathilde Borg Houlberg Thomsen,Morten Muhlig Nielsen,Mirari Marquez,Ulrika Segersten,Mattias Aine,Mattias Höglund,Karin Birkenkamp-Demtröder,Niels Fristrup,Michael Borre,Arndt Hartmann,Robert Stöhr,Sven Wach,Bastian Keck,Anna Katharina Seitz,Roman Nawroth,Tobias Maurer,Cane Tulic,Tatjana Simic,Kerstin Junker,Marcus Horstmann,Niels Harving,Astrid Christine Petersen,M. Luz Calle,Ewout W. Steyerberg,Willemien Beukers,Kim E.M. van Kessel,Jørgen Bjerggaard Jensen,Jakob Skou Pedersen,Per-Uno Malmström,Núria Malats,Francisco X. Real,Ellen C. Zwarthoff,Torben F. Ørntoft,Lars Dyrskjøt +43 more
TL;DR: A comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas revealed frequent mutations in genes encoding proteins involved in chromatin organization and cytoskeletal functions and suggested the identification of subclasses in NMIBC may offer better prognostication and treatment selection based on subclass assignment.
Journal ArticleDOI
Toward the blood-borne miRNome of human diseases
Andreas Keller,Petra Leidinger,Andrea S. Bauer,Abdou ElSharawy,Jan Haas,Christina Backes,Anke Wendschlag,Nathalia Giese,Christine Tjaden,Katja Ott,Jens Werner,Thilo Hackert,Klemens Ruprecht,Hanno Huwer,Junko Huebers,Gunnar Jacobs,Philip Rosenstiel,Henrik Dommisch,Arne S. Schaefer,Joachim Müller-Quernheim,Bernd Wullich,Bastian Keck,Norbert Graf,Joerg Reichrath,Britta Vogel,Almut Nebel,Sven Uwe Jager,Peer F Staehler,Ioannis Amarantos,Valesca Boisguerin,Cord F Staehler,Markus Beier,Matthias Scheffler,Markus W. Büchler,J Wischhusen,Sebastian F M Haeusler,Johannes Dietl,Sylvia Hofmann,Hans-Peter Lenhof,Stefan Schreiber,Hugo A. Katus,Wolfgang Rottbauer,Benjamin Meder,Joerg Hoheisel,Andre Franke,Eckart Meese +45 more
TL;DR: In a multicenter study, the expression profiles of 863 microRNAs were determined by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and this 'miRNome' was validated by quantitative real-time PCR.
Journal ArticleDOI
MicroRNA profiles of prostate carcinoma detected by multiplatform microRNA screening.
Sven Wach,Elke Nolte,Jaroslaw Szczyrba,Robert Stöhr,Arndt Hartmann,Torben F. Ørntoft,Lars Dyrskjøt,Elke Eltze,Wolf F. Wieland,Bastian Keck,Arif B. Ekici,Friedrich A. Grässer,Bernd Wullich +12 more
TL;DR: The results indicate that combinations of miRNAs are promising biomarkers for the diagnosis of prostate cancer and extend the knowledge about the deregulation of mi RNAs in prostate cancer.
Journal ArticleDOI
The Tumor Immune Microenvironment Drives a Prognostic Relevance that Correlates with Bladder Cancer Subtypes
Carolin Pfannstiel,Pamela L. Strissel,Katherine B. Chiappinelli,Danijel Sikic,Sven Wach,Ralph M. Wirtz,Adrian Wullweber,Helge Taubert,Johannes Breyer,Wolfgang Otto,Thomas Stefan Worst,Maximilian Burger,Bernd Wullich,Christian Bolenz,Nicole Fuhrich,Carol Geppert,Veronika Weyerer,Robert Stoehr,Simone Bertz,Bastian Keck,Franziska Erlmeier,Philipp Erben,Arndt Hartmann,Reiner Strick,Markus Eckstein +24 more
TL;DR: It is demonstrated that the quantity and spatial distribution of stromal tumor-infiltrating lymphocytes (sTIL) within the tumor immune microenvironment (TIME) predict stages of tumor inflammation, subtypes, and patient survival and correlate with expression of immune checkpoints in an analysis of 542 patients with MIBC.
Journal ArticleDOI
The plasmacytoid carcinoma of the bladder--rare variant of aggressive urothelial carcinoma.
Bastian Keck,Robert Stoehr,Sven Wach,Anja Rogler,Ferdinand Hofstaedter,Jan Lehmann,Rodolfo Montironi,Mathilde Sibonye,H.-M. Fritsche,Antonio Lopez-Beltran,Jonathan I. Epstein,Bernd Wullich,Arndt Hartmann +12 more
TL;DR: PUC is an aggressive variant of bladder cancer with molecular features of advanced bladder cancer and evidence of WNT pathway activation in some of the cases.