Beatrice Borsari

TL;DR: The largest-to-date lncRNA knockdown data set with molecular phenotyping is disseminated for further exploration and functional roles for ZNF213-AS1 and lnc-KHDC3L-2 are highlighted.

TL;DR: The results demonstrate that CTCF-dependent genome topology is not strictly required for a functional cell-fate conversion but facilitates a rapid and efficient response to an external stimulus and is dispensable for transdifferentiation of B cells into induced macrophages despite widespread loss of topologically associating domains.

TL;DR: The Genotype-Tissue Expression (GTEx) project was supported by the Common Fund of the Office of the Director of the National Institutes of Health (http://commonfund.nih.gov/GTEx). D.G.-M.B. as discussed by the authors is supported by a Caixa-Severo Ochoa pre-doctoral fellowship (LCF/BQ/SO15/52260001).

TL;DR: It is found that sQTLs often target the global splicing pattern of genes, rather than individual splicing events, and tend to be preferentially located in introns that are post-transcriptionally spliced, which would act as hotspots for splicing regulation.

TL;DR: It is shown that RBPs frequently bind their own pre-mRNAs, their exons respond prominently to NMD pathway disruption, and that the responding exons are enriched with nearby eCLIP peaks.